UHRF2 and FANCD2

Number of citations of the paper that reports this interaction (PubMedID 27114453)
63

Data Source:
BioGRID (affinity chromatography technology, imaging technique, pull down)

		UHRF2	FANCD2
Description		ubiquitin like with PHD and ring finger domains 2	FA complementation group D2
Image
GO Annotations	Cellular Component	Heterochromatin Nucleus Nucleoplasm Chromosome Pericentric Heterochromatin	Chromatin Condensed Chromosome Nucleus Nucleoplasm Nucleolus Cytosol Nuclear Body DNA Repair Complex
	Molecular Function	DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity SUMO Transferase Activity Histone Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Ubiquitin Protein Ligase Activity Histone H3K9me2/3 Reader Activity	Protein Binding DNA Polymerase Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Protein Ubiquitination Protein Sumoylation Cell Differentiation Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Regulation Of Cell Cycle Protein Autoubiquitination	DNA Repair DNA Damage Response Homologous Chromosome Pairing At Meiosis Gamete Generation Response To Gamma Radiation Mitotic Intra-S DNA Damage Checkpoint Signaling Cellular Response To Oxidative Stress Interstrand Cross-link Repair Regulation Of Regulatory T Cell Differentiation Brain Morphogenesis Regulation Of Inflammatory Response Neuronal Stem Cell Population Maintenance Double-strand Break Repair Involved In Meiotic Recombination Regulation Of CD40 Signaling Pathway
Pathways		SUMOylation of transcription cofactors	Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes
Drugs
Diseases			Fanconi anemia
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474 31959851) Asthma or allergic disease (pleiotropy) ( 29785011) Periodontal microbiota ( 22699663)	Alzheimer's disease ( 24755620) Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes		42 interacting genes: ATR ATXN1 BAX BCAR1 BCL2L1 CCND1 CD27 CDK1 CDK2 CDK4 CDK6 CTNNB1 DESI1 FANCD2 FYN H3C1 HMGB1 HMGB2 JAK3 LCK LYN MCL1 PCNP PTPRC RAD51 RBCK1 RUNX1 SKP1 SMAD4 TP53 TRIM27 TRIM8 UBE2D1 UBE2D2 UBE2D4 UBE2K UBE2W UHRF1 XRCC1 YY1 ZNF410 ZNF618	30 interacting genes: ATM ATR BLM BRCA1 BRCA2 BRIP1 FANCC FANCE FANCI FANCL H2AC4 H2BC3 H3C1 H4C1 MEN1 MRE11 NBN PCNA RAD51 TERF1 TNFRSF1A TNFRSF1B TNKS UBB UBE2T UHRF1 UHRF2 USP1 USP2 USP7
Entrez ID		115426	2177
HPRD ID		18257	01968
Ensembl ID		ENSG00000147854	ENSG00000144554
Uniprot IDs		Q96PU4	A0A6Q8PFY3 Q9BXW9
PDB IDs		1WY8 1Z6U 2E6S 3OLN 4PW5 4PW6 4PW7 4TVR 5YCO	6VAA 6VAD 6VAE 6VAF 7AY1 7KZQ 7KZR 7KZS 7KZT 7KZV 7ZF1 8A9J 8A9K
Enriched GO Terms of Interacting Partners?		DNA Damage Response Response To Gamma Radiation Post-translational Protein Modification Nucleus Regulation Of Apoptotic Process Protein Modification Process Regulation Of Programmed Cell Death Chromosome Organization Lymphocyte Activation Cellular Response To Stress Macromolecule Metabolic Process Regulation Of Metabolic Process Protein Polyubiquitination Protein Ubiquitination Regulation Of Multicellular Organismal Development Negative Regulation Of Metabolic Process Response To Ionizing Radiation DNA Repair Double-strand Break Repair Cell Activation Response To Stress Positive Regulation Of Apoptotic Process Negative Regulation Of Transcription By RNA Polymerase II DNA Damage Checkpoint Signaling Regulation Of Macromolecule Metabolic Process Regulation Of Hemopoiesis Regulation Of Cell Development Positive Regulation Of Programmed Cell Death Protein Modification By Small Protein Conjugation Leukocyte Activation Intracellular Signal Transduction Regulation Of Primary Metabolic Process Response To Alcohol Signal Transduction Extrinsic Apoptotic Signaling Pathway Regulation Of Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Macromolecule Metabolic Process Ubiquitin Conjugating Enzyme Activity Regulation Of DNA Metabolic Process Leukocyte Differentiation Condensed Chromosome Regulation Of Apoptotic Signaling Pathway Regulation Of T Cell Activation Response To Xenobiotic Stimulus Transferase Activity T Cell Activation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Differentiation Cell Surface Receptor Signaling Pathway	DNA Damage Response DNA Repair DNA Metabolic Process Chromosome, Telomeric Region Chromosome Telomere Organization Cellular Response To Stress Nucleoplasm Telomere Maintenance Nucleic Acid Metabolic Process Chromosome Organization Homologous Recombination Interstrand Cross-link Repair Chromatin Remodeling Chromatin Organization Double-strand Break Repair Replication Fork Nucleobase-containing Compound Metabolic Process Regulation Of DNA Metabolic Process DNA Strand Resection Involved In Replication Fork Processing Macromolecule Metabolic Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Nucleus Signal Transduction In Response To DNA Damage DNA Recombination Negative Regulation Of Cell Cycle DNA Damage Checkpoint Signaling Mitotic G2/M Transition Checkpoint DNA Double-strand Break Processing Regulation Of Cell Cycle Regulation Of Telomere Maintenance Negative Regulation Of Cell Cycle Process DNA Binding Response To Stress Positive Regulation Of DNA Metabolic Process Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Response To Radiation Negative Regulation Of Cell Cycle G2/M Phase Transition Cellular Response To Ionizing Radiation Positive Regulation Of Telomere Maintenance Negative Regulation Of DNA Metabolic Process Mitotic G2 DNA Damage Checkpoint Signaling Response To Ionizing Radiation Regulation Of DNA Repair Post-translational Protein Modification DNA Repair Complex Regulation Of Telomere Capping Regulation Of DNA Biosynthetic Process Lateral Element
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