UHRF2 and BAX

Number of citations of the paper that reports this interaction (PMID 21952639)
4

Data Source:
BioGRID (far western blotting)

		UHRF2	BAX
Gene Name		ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase	BCL2-associated X protein
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Heterochromatin	Nucleus Nuclear Envelope Mitochondrion Mitochondrial Outer Membrane Mitochondrial Permeability Transition Pore Complex Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Pore Complex Extracellular Vesicular Exosome Bcl-2 Family Protein Complex BAX Complex
	Molecular Function	DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Histone Binding Ubiquitin Protein Ligase Activity	Protein Binding Lipid Binding Channel Activity Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity BH3 Domain Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Cell Cycle Cell Proliferation Protein Ubiquitination Cell Differentiation Regulation Of Cell Cycle Protein Autoubiquitination Positive Regulation Of Cell Cycle Arrest	Ovarian Follicle Development Neuron Migration T Cell Homeostatic Proliferation B Cell Homeostasis B Cell Apoptotic Process Kidney Development Release Of Cytochrome C From Mitochondria Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Blood Vessel Remodeling Myeloid Cell Homeostasis B Cell Negative Selection B Cell Homeostatic Proliferation Positive Regulation Of B Cell Apoptotic Process Glycosphingolipid Metabolic Process Regulation Of Nitrogen Utilization Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Transformed Cell Apoptotic Process Germ Cell Development Mitochondrial Fusion Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Apoptotic Mitochondrial Changes Fertilization Response To Toxic Substance Response To Salt Stress Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Response To Gamma Radiation Viral Process Hypothalamus Development Cerebral Cortex Development Negative Regulation Of Protein Binding Positive Regulation Of Protein Oligomerization Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Release Of Matrix Enzymes From Mitochondria Negative Regulation Of Peptidyl-serine Phosphorylation Regulation Of Mammary Gland Epithelial Cell Proliferation Cellular Response To UV Ectopic Germ Cell Programmed Cell Death Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Apoptotic Process Regulation Of Protein Homodimerization Activity Regulation Of Protein Heterodimerization Activity Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Mitochondrial Fragmentation Involved In Apoptotic Process Development Of Secondary Sexual Characteristics Retinal Cell Programmed Cell Death Positive Regulation Of Developmental Pigmentation Negative Regulation Of Fibroblast Proliferation Spermatid Differentiation Post-embryonic Camera-type Eye Morphogenesis Response To Axon Injury Homeostasis Of Number Of Cells Within A Tissue Protein Oligomerization Protein Homooligomerization Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Neuron Apoptotic Process Regulation Of Cell Cycle Regulation Of Mitochondrial Membrane Potential Sertoli Cell Proliferation Retina Development In Camera-type Eye Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Vagina Development Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Thymocyte Apoptotic Process Mitochondrion Morphogenesis Cellular Response To Organic Substance Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Release Of Cytochrome C From Mitochondria Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Apoptotic Process Involved In Patterning Of Blood Vessels Apoptotic Process Involved In Embryonic Digit Morphogenesis Regulation Of Mitochondrial Membrane Permeability Involved In Programmed Necrotic Cell Death Positive Regulation Of Apoptotic DNA Fragmentation Retinal Cell Apoptotic Process B Cell Receptor Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways			Activation, translocation and oligomerization of BAX Programmed Cell Death Intrinsic Pathway for Apoptosis
Drugs
Diseases
GWAS		Periodontal microbiota ( 22699663)
Protein-Protein Interactions		37 interactors: ATXN1 BAX BCAR1 BCL2L1 CCND1 CD27 CDK1 CDK2 CDK4 CDK6 CTNNB1 FYN HDAC1 HIST1H3A JAK3 LCK LYN MCL1 PCNA PCNP PTPRC RAD51 RB1 RBCK1 SKP1 SMAD4 TP53 TRIM27 TRIM8 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2K UBE2W USP7 YY1	25 interactors: BAK1 BBC3 BCL2 BCL2A1 BCL2L1 BCL2L10 BID BNIPL ERN1 KCNA3 MCL1 MOAP1 NOL3 PARK7 PMAIP1 PPP1CA SFN SH3GLB1 SLC25A4 SNCA UHRF2 VDAC1 YWHAB YWHAQ ZBTB24
Entrez ID		115426	581
HPRD ID		18257	02498
Ensembl ID		ENSG00000147854	ENSG00000087088
Uniprot IDs		Q96PU4	Q07812
PDB IDs		1WY8 1Z6U 2E6S 3OLN	1F16 2G5B 2K7W 2LR1 3PK1 3PL7 4BD2 4BD6 4BD7 4BD8 4BDU
Enriched GO Terms of Interacting Partners?		Response To Stress Cellular Response To Stimulus Response To Stimulus Response To Organic Substance Response To Abiotic Stimulus Regulation Of Immune System Process Signaling Immune System Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Metabolic Process Signal Transduction Cell Communication Proteasomal Protein Catabolic Process Regulation Of Metabolic Process Cellular Protein Modification Process Cellular Response To DNA Damage Stimulus Regulation Of Cell Proliferation Cellular Response To Stress Regulation Of Cell Death Positive Regulation Of Immune System Process Negative Regulation Of Cellular Metabolic Process Cell Cycle Cell Surface Receptor Signaling Pathway Cellular Response To Organic Substance Negative Regulation Of Cell Cycle Immune Response-regulating Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Apoptotic Process G1/S Transition Of Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Signal Transduction Modification-dependent Protein Catabolic Process Cell Cycle Process Cell Cycle Phase Transition Protein Polyubiquitination Positive Regulation Of Metabolic Process Regulation Of Immune Response Proteolysis Involved In Cellular Protein Catabolic Process Viral Process Cellular Protein Catabolic Process Regulation Of Cell Cycle Positive Regulation Of Apoptotic Signaling Pathway Mitotic Cell Cycle Positive Regulation Of Apoptotic Process Protein Ubiquitination Positive Regulation Of Programmed Cell Death Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cell Death	Apoptotic Process Programmed Cell Death Cell Death Death Intrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Apoptotic Mitochondrial Changes Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrion Organization Positive Regulation Of Mitochondrion Organization Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Cell Death Positive Regulation Of Cell Death Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Release Of Cytochrome C From Mitochondria Mitochondrion Organization Regulation Of Apoptotic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Intrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Mitochondrial Membrane Organization Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Mitochondrial Membrane Permeability Regulation Of Signaling Positive Regulation Of Intracellular Transport Regulation Of Membrane Permeability Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Intracellular Transport Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Intracellular Signal Transduction Cellular Response To Stress Positive Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Endopeptidase Activity Regulation Of Cellular Localization Positive Regulation Of Organelle Organization Regulation Of Peptidase Activity Regulation Of Mitochondrial Membrane Potential Cellular Response To DNA Damage Stimulus Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Regulation Of Organelle Organization Regulation Of Establishment Of Protein Localization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Tagcloud ?		aberrant base ber carcinogenesis confocal dissect endogenous excision finger glycosylase homolog immunoprecipitation interact interacted interacting ip link linkage localized maintenance methylpurine mpg nucleoplasm phd providing repair screened uhrf1	androgen bad bak colocalization dawley die dimethanesulfonate eds ethane fas fragmented germ governing hydroxysteroid killed leydig pachytene postinjection programmed sertoli spermatids spermatocytes spermatogenesis spermatogenic sprague testes withdraw withdrawal xl
Tagcloud (Difference) ?		aberrant base ber carcinogenesis confocal dissect endogenous excision finger glycosylase homolog immunoprecipitation interact interacted interacting ip link linkage localized maintenance methylpurine mpg nucleoplasm phd providing repair screened uhrf1	androgen bad bak colocalization dawley die dimethanesulfonate eds ethane fas fragmented germ governing hydroxysteroid killed leydig pachytene postinjection programmed sertoli spermatids spermatocytes spermatogenesis spermatogenic sprague testes withdraw withdrawal xl
Tagcloud (Intersection) ?