UHRF2 and XRCC1

Number of citations of the paper that reports this interaction (PubMedID 34111398)
0

Data Source:
BioGRID (enzymatic study)

		UHRF2	XRCC1
Description		ubiquitin like with PHD and ring finger domains 2	X-ray repair cross complementing 1
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GO Annotations	Cellular Component	Heterochromatin Nucleus Nucleoplasm Chromosome Pericentric Heterochromatin	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Chromosome Nucleolus ERCC4-ERCC1 Complex Site Of DNA Damage
	Molecular Function	DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity SUMO Transferase Activity Histone Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Ubiquitin Protein Ligase Activity Histone H3K9me2/3 Reader Activity	Damaged DNA Binding Protein Binding Enzyme Binding Oxidized DNA Binding Poly-ADP-D-ribose Binding ADP-D-ribose Modification-dependent Protein Binding 3' Overhang Single-stranded DNA Endodeoxyribonuclease Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Protein Ubiquitination Protein Sumoylation Cell Differentiation Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Regulation Of Cell Cycle Protein Autoubiquitination	Single Strand Break Repair DNA Repair Base-excision Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Damage Response Negative Regulation Of Protein ADP-ribosylation Hippocampus Development Response To Hydroperoxide Telomeric DNA-containing Double Minutes Formation Regulation Of Base-excision Repair Negative Regulation Of Protection From Non-homologous End Joining At Telomere
Pathways		SUMOylation of transcription cofactors	Resolution of AP sites via the single-nucleotide replacement pathway APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway HDR through MMEJ (alt-NHEJ) Gap-filling DNA repair synthesis and ligation in GG-NER Gap-filling DNA repair synthesis and ligation in TC-NER
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474 31959851) Asthma or allergic disease (pleiotropy) ( 29785011) Periodontal microbiota ( 22699663)	Apolipoprotein B levels ( 32203549) Height ( 31562340) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Plasma amyloid beta peptide concentrations (ABx-42) ( 24535457)
Interacting Genes		42 interacting genes: ATR ATXN1 BAX BCAR1 BCL2L1 CCND1 CD27 CDK1 CDK2 CDK4 CDK6 CTNNB1 DESI1 FANCD2 FYN H3C1 HMGB1 HMGB2 JAK3 LCK LYN MCL1 PCNP PTPRC RAD51 RBCK1 RUNX1 SKP1 SMAD4 TP53 TRIM27 TRIM8 UBE2D1 UBE2D2 UBE2D4 UBE2K UBE2W UHRF1 XRCC1 YY1 ZNF410 ZNF618	21 interacting genes: ANXA1 APEX1 APLF APTX BRCA1 BTRC CHEK2 CSNK2A1 CSNK2A2 LIG3 NEIL1 OGG1 PARP1 PARP2 PCNA PNKP POLB RNF146 TOPORS UBE2I UHRF2
Entrez ID		115426	7515
HPRD ID		18257	01909
Ensembl ID		ENSG00000147854	ENSG00000073050
Uniprot IDs		Q96PU4	B2RCY5 P18887 Q59HH7
PDB IDs		1WY8 1Z6U 2E6S 3OLN 4PW5 4PW6 4PW7 4TVR 5YCO	1CDZ 1XNA 1XNT 2D8M 2W3O 3K75 3K77 3LQC 5E6Q 5W7X 5W7Y 6WH1 6WH2
Enriched GO Terms of Interacting Partners?		DNA Damage Response Response To Gamma Radiation Post-translational Protein Modification Nucleus Regulation Of Apoptotic Process Protein Modification Process Regulation Of Programmed Cell Death Chromosome Organization Lymphocyte Activation Cellular Response To Stress Macromolecule Metabolic Process Regulation Of Metabolic Process Protein Polyubiquitination Protein Ubiquitination Regulation Of Multicellular Organismal Development Negative Regulation Of Metabolic Process Response To Ionizing Radiation DNA Repair Double-strand Break Repair Cell Activation Response To Stress Positive Regulation Of Apoptotic Process Negative Regulation Of Transcription By RNA Polymerase II DNA Damage Checkpoint Signaling Regulation Of Macromolecule Metabolic Process Regulation Of Hemopoiesis Regulation Of Cell Development Positive Regulation Of Programmed Cell Death Protein Modification By Small Protein Conjugation Leukocyte Activation Intracellular Signal Transduction Regulation Of Primary Metabolic Process Response To Alcohol Signal Transduction Extrinsic Apoptotic Signaling Pathway Regulation Of Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Macromolecule Metabolic Process Ubiquitin Conjugating Enzyme Activity Regulation Of DNA Metabolic Process Leukocyte Differentiation Condensed Chromosome Regulation Of Apoptotic Signaling Pathway Regulation Of T Cell Activation Response To Xenobiotic Stimulus Transferase Activity T Cell Activation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Differentiation Cell Surface Receptor Signaling Pathway	Damaged DNA Binding DNA Repair DNA Damage Response DNA Metabolic Process Base-excision Repair, Gap-filling Nucleoplasm Double-strand Break Repair Macromolecule Metabolic Process Cellular Response To Stress Base-excision Repair Nucleic Acid Metabolic Process Nucleus DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Nucleobase-containing Compound Metabolic Process Response To Stress Double-strand Break Repair Via Nonhomologous End Joining DNA Modification Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Poly-ADP-D-ribose Binding Catalytic Activity Regulation Of DNA Metabolic Process Transferase Activity Regulation Of DNA Repair Post-translational Protein Modification DNA Recombination Response To Radiation NAD+-protein-serine ADP-ribosyltransferase Activity Polynucleotide 3'-phosphatase Activity SUMO Transferase Activity DNA Binding Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Cellular Response To Stress Regulation Of Nucleobase-containing Compound Metabolic Process DNA Repair-dependent Chromatin Remodeling DNA ADP-ribosylation NAD DNA ADP-ribosyltransferase Activity Protein Kinase CK2 Complex Response To Oxidative Stress Chromatin Organization Negative Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Enzyme Binding Protein Localization To Chromosome PML Body Chromatin Remodeling Protein Modification Process Chromosome Protein Modification By Small Protein Conjugation Negative Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process
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