UHRF2 and UBE2K

Number of citations of the paper that reports this interaction (PMID 19549727)
40

Data Source:
BioGRID (two hybrid)

		UHRF2	UBE2K
Gene Name		ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase	ubiquitin-conjugating enzyme E2K
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Heterochromatin	Nucleus Cytoplasm Actin Cytoskeleton Intermediate Filament Cytoskeleton Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Histone Binding Ubiquitin Protein Ligase Activity	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Cell Cycle Cell Proliferation Protein Ubiquitination Cell Differentiation Regulation Of Cell Cycle Protein Autoubiquitination Positive Regulation Of Cell Cycle Arrest	Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Protein K48-linked Ubiquitination
Pathways			RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Antigen processing: Ubiquitination & Proteasome degradation Negative regulators of RIG-I/MDA5 signaling Class I MHC mediated antigen processing & presentation Innate Immune System Adaptive Immune System
Drugs
Diseases
GWAS		Periodontal microbiota ( 22699663)
Protein-Protein Interactions		37 interactors: ATXN1 BAX BCAR1 BCL2L1 CCND1 CD27 CDK1 CDK2 CDK4 CDK6 CTNNB1 FYN HDAC1 HIST1H3A JAK3 LCK LYN MCL1 PCNA PCNP PTPRC RAD51 RB1 RBCK1 SKP1 SMAD4 TP53 TRIM27 TRIM8 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2K UBE2W USP7 YY1	68 interactors: AMFR ANAPC11 BFAR BIRC7 BIRC8 BRCA1 CASP12 CBLC CDC6 DDI1 DDX58 DIABLO DTX3 DTX3L DZIP3 FZR1 HTT ITCH ITSN1 LRSAM1 MARCH3 MARCH7 MDM2 MID1 MIPOL1 MKRN2 MKRN3 NEDD4L NEDD8 NFKB1 NUB1 PIAS4 PRPF40A PRRG4 RBCK1 REL RING1 RNF111 RNF114 RNF125 RNF138 RNF144A RNF167 RNF2 RNF32 RNF4 RNF41 RNF5 SIAH1 TP53 TRAF7 TRAIP TRIM2 TRIM27 TRIM3 TRIM31 TRIM34 TRIM35 TRIM39 TRIM43 TRIM5 UBA1 UBC UBE2I UBOX5 UHRF2 WWP2 ZDHHC17
Entrez ID		115426	3093
HPRD ID		18257	04165
Ensembl ID		ENSG00000147854	ENSG00000078140
Uniprot IDs		Q96PU4	B4DIZ2 P61086
PDB IDs		1WY8 1Z6U 2E6S 3OLN	1YLA 2O25 3E46 3F92 3K9O 3K9P
Enriched GO Terms of Interacting Partners?		Response To Stress Cellular Response To Stimulus Response To Stimulus Response To Organic Substance Response To Abiotic Stimulus Regulation Of Immune System Process Signaling Immune System Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Metabolic Process Signal Transduction Cell Communication Proteasomal Protein Catabolic Process Regulation Of Metabolic Process Cellular Protein Modification Process Cellular Response To DNA Damage Stimulus Regulation Of Cell Proliferation Cellular Response To Stress Regulation Of Cell Death Positive Regulation Of Immune System Process Negative Regulation Of Cellular Metabolic Process Cell Cycle Cell Surface Receptor Signaling Pathway Cellular Response To Organic Substance Negative Regulation Of Cell Cycle Immune Response-regulating Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Apoptotic Process G1/S Transition Of Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Signal Transduction Modification-dependent Protein Catabolic Process Cell Cycle Process Cell Cycle Phase Transition Protein Polyubiquitination Positive Regulation Of Metabolic Process Regulation Of Immune Response Proteolysis Involved In Cellular Protein Catabolic Process Viral Process Cellular Protein Catabolic Process Regulation Of Cell Cycle Positive Regulation Of Apoptotic Signaling Pathway Mitotic Cell Cycle Positive Regulation Of Apoptotic Process Protein Ubiquitination Positive Regulation Of Programmed Cell Death Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cell Death	Protein Modification By Small Protein Conjugation Protein Ubiquitination Cellular Protein Modification Process Protein Polyubiquitination Cellular Protein Metabolic Process Protein Metabolic Process Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Proteolysis Proteasomal Protein Catabolic Process Apoptotic Process Programmed Cell Death Cell Death Death Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Cell Death Protein K63-linked Ubiquitination Negative Regulation Of Cellular Metabolic Process Metabolic Process Regulation Of Apoptotic Process Catabolic Process Protein Autoubiquitination Positive Regulation Of Signal Transduction Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of RNA Biosynthetic Process Viral Process Neuron Apoptotic Process Response To Stress Negative Regulation Of Biosynthetic Process Regulation Of Viral Release From Host Cell Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Process Neuron Death Regulation Of Signaling Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cell Cycle
Tagcloud ?		aberrant base ber carcinogenesis confocal dissect endogenous excision finger glycosylase homolog immunoprecipitation interact interacted interacting ip link linkage localized maintenance methylpurine mpg nucleoplasm phd providing repair screened uhrf1	antiviral attributes breadth chains conjugase cooperated demands e3 elicits elusive epsilon hundreds identifies ifn ikkepsilon interacted interferons isg isgs k48 ligase polyubiquitin stat1 trim trim6 tripartite ubiquitin unanchored unrecognized
Tagcloud (Difference) ?		aberrant base ber carcinogenesis confocal dissect endogenous excision finger glycosylase homolog immunoprecipitation interact interacting ip link linkage localized maintenance methylpurine mpg nucleoplasm phd providing repair screened uhrf1	antiviral attributes breadth chains conjugase cooperated demands e3 elicits elusive epsilon hundreds identifies ifn ikkepsilon interferons isg isgs k48 ligase polyubiquitin stat1 trim trim6 tripartite ubiquitin unanchored unrecognized
Tagcloud (Intersection) ?		interacted