TNC and FN1

Number of citations of the paper that reports this interaction (PMID 7499434)
17

Data Source:
HPRD (in vivo, in vitro)

		TNC	FN1
Gene Name		tenascin C	fibronectin 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Basement Membrane Interstitial Matrix Extracellular Space Focal Adhesion Membrane Extracellular Matrix	Extracellular Region Fibrinogen Complex Basal Lamina Extracellular Space Endoplasmic Reticulum-Golgi Intermediate Compartment Apical Plasma Membrane Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Syndecan Binding	Protease Binding Integrin Binding Protein Binding Collagen Binding Heparin Binding Peptidase Activator Activity
	Biological Process	Osteoblast Differentiation Cell Adhesion Negative Regulation Of Cell Adhesion Neuromuscular Junction Development Positive Regulation Of Cell Proliferation Response To Wounding Response To Mechanical Stimulus Positive Regulation Of Gene Expression Peripheral Nervous System Axon Regeneration Extracellular Matrix Organization Wound Healing Odontogenesis Of Dentin-containing Tooth Response To Ethanol Bud Outgrowth Involved In Lung Branching Mesenchymal-epithelial Cell Signaling Involved In Prostate Gland Development Prostate Gland Epithelium Morphogenesis Cellular Response To Retinoic Acid Cellular Response To Vitamin D Response To Fibroblast Growth Factor Cellular Response To Prostaglandin D Stimulus	Angiogenesis Platelet Degranulation Acute-phase Response Cell-substrate Junction Assembly Cell Adhesion Calcium-independent Cell-matrix Adhesion Blood Coagulation Regulation Of Cell Shape Response To Wounding Positive Regulation Of Peptidase Activity Peptide Cross-linking Extracellular Matrix Disassembly Platelet Activation Extracellular Matrix Organization Integrin Activation Substrate Adhesion-dependent Cell Spreading Endodermal Cell Differentiation Positive Regulation Of Axon Extension Leukocyte Migration
Pathways		Syndecan interactions ECM proteoglycans Integrin cell surface interactions Non-integrin membrane-ECM interactions	Elastic fibre formation p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling GRB2:SOS provides linkage to MAPK signaling for Integrins Non-integrin membrane-ECM interactions Platelet degranulation Platelet Aggregation (Plug Formation) Degradation of the extracellular matrix Cell surface interactions at the vascular wall Molecules associated with elastic fibres Syndecan interactions ECM proteoglycans Fibronectin matrix formation Response to elevated platelet cytosolic Ca2+ Integrin cell surface interactions Platelet activation, signaling and aggregation
Drugs			Ocriplasmin
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Prostate cancer (gene x gene interaction) ( 22219177)
Protein-Protein Interactions		6 interactors: CNTN1 EGFR FN1 ITGA5 NCAN PTPRB	96 interactors: ADAMTS4 AMBP APCS ATXN10 ATXN7 C1QA CD44 CDKN2A COL13A1 COL1A1 COL1A2 COL2A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 COL6A2 COL7A1 COMP CRP CTSD CXCL12 DCN DUSP10 EGFR F13A1 FAM86B3P FASLG FBLN1 FBLN2 FST FSTL3 GALNT6 GRB2 GSN HGF HRG HSPG2 IGFBP3 IGFBP5 ITGA3 ITGA4 ITGA5 ITGA8 ITGB1 ITGB3 ITGB6 ITGB7 KLK3 KPNA2 LACRT LGALS3BP LPA LRG1 LTBP1 MAG MATN2 MEP1A MEP1B MIA MMP9 MYOC NOV NR0B2 NT5E PELI2 PKD1 PLAT PLG PRELP PRPF40A RARA RBL1 REG3A RPS6KA5 SCGB1A1 SDC2 SKIL SMAD4 SMAD9 SPARC STAT5A TAB1 TAB2 TAC1 TGFBI TGM2 THBS1 TMPRSS6 TNC TNFRSF11B TSHR UBQLN1 VHL
Entrez ID		3371	2335
HPRD ID		01756	00626
Ensembl ID		ENSG00000041982	ENSG00000115414
Uniprot IDs		B4E1W8 P24821 Q4LE33	P02751 Q6MZF4 Q6MZM7 Q6N084 Q9UQS6
PDB IDs		1TEN 2RB8 2RBL	1E88 1E8B 1FBR 1FNA 1FNF 1FNH 1J8K 1O9A 1OWW 1Q38 1QGB 1QO6 1TTF 1TTG 2CG6 2CG7 2CK2 2CKU 2EC3 2FN2 2FNB 2GEE 2H41 2H45 2HA1 2OCF 2RKY 2RKZ 2RL0 3CAL 3EJH 3GXE 3M7P 3MQL 3R8Q 3T1W 3ZRZ 4GH7 4JE4 4JEG
Enriched GO Terms of Interacting Partners?		Cell Morphogenesis Involved In Differentiation Axon Guidance Cell Morphogenesis Anatomical Structure Morphogenesis Cell Adhesion Locomotion Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Movement Of Cell Or Subcellular Component Chemotaxis Generation Of Neurons Neuron Projection Morphogenesis Neurogenesis Cell Development Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis System Development Endodermal Cell Differentiation Neuron Development Nervous System Development Angiogenesis Cell-substrate Junction Assembly Multicellular Organismal Development Neuron Differentiation Extracellular Matrix Organization Extracellular Structure Organization Cell Projection Organization Endoderm Formation Anatomical Structure Development Blood Vessel Morphogenesis Developmental Process Blood Vessel Development Endoderm Development Vasculature Development Alkanesulfonate Metabolic Process Cell Differentiation Formation Of Primary Germ Layer Response To External Stimulus Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Astrocyte Activation Cell Migration Cardiovascular System Development Gastrulation Activation Of Phospholipase A2 Activity Calcium-independent Cell-matrix Adhesion Cell Motility Cell Junction Assembly Regulation Of Peptidyl-tyrosine Phosphorylation	Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Developmental Process Multicellular Organismal Development Anatomical Structure Morphogenesis System Development Anatomical Structure Development Collagen Catabolic Process Response To Stimulus Response To External Stimulus Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Locomotion Multicellular Organismal Metabolic Process Cell Differentiation Wound Healing Tissue Development Response To Wounding Axon Guidance Response To Growth Factor Response To Organic Substance Organ Development Response To Stress Cellular Response To Stimulus Cell Morphogenesis Involved In Differentiation Movement Of Cell Or Subcellular Component Neurogenesis Generation Of Neurons Chemotaxis Regulation Of Cell Adhesion Cell Adhesion Axon Development Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Axonogenesis Cell Projection Organization Cell Morphogenesis Cardiovascular System Development Nervous System Development Neuron Projection Development Skeletal System Development Cell Morphogenesis Involved In Neuron Differentiation Anatomical Structure Formation Involved In Morphogenesis Neuron Development Regulation Of Locomotion Organ Morphogenesis Cell Communication Neuron Projection Morphogenesis
Tagcloud ?		actual anaerobically analyser automatic avoid bridge calcium capillary cca2 co2 connection eliminated equilibrium erythrocytes formate ica ingestion ionized junction muscular precipitation puncture semi stasis stored tonometer tubes turntable venous	2q33 2q34 artificial bcg brazilian exon il8 il8r il8ra il8rb ity leishmaniasis leprosy linkage lod lsh nramp pedigrees proline pseudogene q35 q37 segregating sh3 synteny tnp1 typed vil1 visceral
Tagcloud (Difference) ?		actual anaerobically analyser automatic avoid bridge calcium capillary cca2 co2 connection eliminated equilibrium erythrocytes formate ica ingestion ionized junction muscular precipitation puncture semi stasis stored tonometer tubes turntable venous	2q33 2q34 artificial bcg brazilian exon il8 il8r il8ra il8rb ity leishmaniasis leprosy linkage lod lsh nramp pedigrees proline pseudogene q35 q37 segregating sh3 synteny tnp1 typed vil1 visceral
Tagcloud (Intersection) ?