TNC and ITGA5

Number of citations of the paper that reports this interaction (PMID 9314546)
63

Data Source:
HPRD (in vivo)

		TNC	ITGA5
Gene Name		tenascin C	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Basement Membrane Interstitial Matrix Extracellular Space Focal Adhesion Membrane Extracellular Matrix	Ruffle Cytoplasm Plasma Membrane Cell-cell Junction Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Ruffle Membrane Synapse Alphav-beta3 Integrin-vitronectin Complex
	Molecular Function	Syndecan Binding	Epidermal Growth Factor Receptor Binding Platelet-derived Growth Factor Receptor Binding Integrin Binding Protein Binding Vascular Endothelial Growth Factor Receptor 2 Binding Metal Ion Binding
	Biological Process	Osteoblast Differentiation Cell Adhesion Negative Regulation Of Cell Adhesion Neuromuscular Junction Development Positive Regulation Of Cell Proliferation Response To Wounding Response To Mechanical Stimulus Positive Regulation Of Gene Expression Peripheral Nervous System Axon Regeneration Extracellular Matrix Organization Wound Healing Odontogenesis Of Dentin-containing Tooth Response To Ethanol Bud Outgrowth Involved In Lung Branching Mesenchymal-epithelial Cell Signaling Involved In Prostate Gland Development Prostate Gland Epithelium Morphogenesis Cellular Response To Retinoic Acid Cellular Response To Vitamin D Response To Fibroblast Growth Factor Cellular Response To Prostaglandin D Stimulus	Angiogenesis Cell-substrate Junction Assembly Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Integrin-mediated Signaling Pathway Axon Guidance Blood Coagulation Memory Positive Regulation Of Cell-substrate Adhesion Viral Process Extracellular Matrix Organization Positive Regulation Of Cell Migration Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell-substrate Adhesion Cell-cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Wound Healing, Spreading Of Epidermal Cells Endodermal Cell Differentiation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Leukocyte Migration Negative Regulation Of Anoikis
Pathways		Syndecan interactions ECM proteoglycans Integrin cell surface interactions Non-integrin membrane-ECM interactions	Signal transduction by L1 Axon guidance Elastic fibre formation Fibronectin matrix formation L1CAM interactions Integrin cell surface interactions Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Prostate cancer (gene x gene interaction) ( 22219177)
Protein-Protein Interactions		6 interactors: CNTN1 EGFR FN1 ITGA5 NCAN PTPRB	24 interactors: ANGPT1 ANGPTL3 ARHGAP5 AUP1 CD9 COL18A1 COL1A1 EGFR ERBB2 FGFR2 FLT4 FN1 GIPC1 GRK6 ITGB1 ITGB3 ITGB5 L1CAM NISCH PECAM1 RABIF SPP1 STAMBP TNC
Entrez ID		3371	3678
HPRD ID		01756	00627
Ensembl ID		ENSG00000041982	ENSG00000161638
Uniprot IDs		B4E1W8 P24821 Q4LE33	P08648
PDB IDs		1TEN 2RB8 2RBL	3VI3 3VI4
Enriched GO Terms of Interacting Partners?		Cell Morphogenesis Involved In Differentiation Axon Guidance Cell Morphogenesis Anatomical Structure Morphogenesis Cell Adhesion Locomotion Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Movement Of Cell Or Subcellular Component Chemotaxis Generation Of Neurons Neuron Projection Morphogenesis Neurogenesis Cell Development Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis System Development Endodermal Cell Differentiation Neuron Development Nervous System Development Angiogenesis Cell-substrate Junction Assembly Multicellular Organismal Development Neuron Differentiation Extracellular Matrix Organization Extracellular Structure Organization Cell Projection Organization Endoderm Formation Anatomical Structure Development Blood Vessel Morphogenesis Developmental Process Blood Vessel Development Endoderm Development Vasculature Development Alkanesulfonate Metabolic Process Cell Differentiation Formation Of Primary Germ Layer Response To External Stimulus Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Astrocyte Activation Cell Migration Cardiovascular System Development Gastrulation Activation Of Phospholipase A2 Activity Calcium-independent Cell-matrix Adhesion Cell Motility Cell Junction Assembly Regulation Of Peptidyl-tyrosine Phosphorylation	Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Cell Adhesion Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Cell Migration Regulation Of Cell Motility Cardiovascular System Development Regulation Of Locomotion Regulation Of Cellular Component Movement Blood Vessel Development Vasculature Development Leukocyte Migration Response To Stimulus Positive Regulation Of Cell Proliferation Wound Healing Regulation Of Cell Proliferation Anatomical Structure Morphogenesis Response To Wounding Cell-substrate Adhesion Cell Migration Response To Growth Factor Movement Of Cell Or Subcellular Component Multicellular Organismal Development Blood Vessel Morphogenesis Blood Coagulation Cell Motility Hemostasis System Development Anatomical Structure Development Cellular Response To Stimulus Locomotion Cell Communication Positive Regulation Of Signal Transduction Regulation Of Signaling Cell-matrix Adhesion Angiogenesis Anatomical Structure Formation Involved In Morphogenesis Regulation Of Signal Transduction Developmental Process Response To Vitamin Response To Nutrient Regulation Of Body Fluid Levels Signaling Cell Activation Regulation Of Cellular Process Formation Of Primary Germ Layer Signal Transduction
Tagcloud ?		actual anaerobically analyser automatic avoid bridge calcium capillary cca2 co2 connection eliminated equilibrium erythrocytes formate ica ingestion ionized junction muscular precipitation puncture semi stasis stored tonometer tubes turntable venous
Tagcloud (Difference) ?		actual anaerobically analyser automatic avoid bridge calcium capillary cca2 co2 connection eliminated equilibrium erythrocytes formate ica ingestion ionized junction muscular precipitation puncture semi stasis stored tonometer tubes turntable venous
Tagcloud (Intersection) ?