TNC and CNTN1

Number of citations of the paper that reports this interaction (PMID 10103110)
8

Data Source:
HPRD (in vivo)

		TNC	CNTN1
Gene Name		tenascin C	contactin 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Basement Membrane Interstitial Matrix Extracellular Space Focal Adhesion Membrane Extracellular Matrix	Plasma Membrane Membrane Anchored Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Syndecan Binding	Glycoprotein Binding Carbohydrate Binding
	Biological Process	Osteoblast Differentiation Cell Adhesion Negative Regulation Of Cell Adhesion Neuromuscular Junction Development Positive Regulation Of Cell Proliferation Response To Wounding Response To Mechanical Stimulus Positive Regulation Of Gene Expression Peripheral Nervous System Axon Regeneration Extracellular Matrix Organization Wound Healing Odontogenesis Of Dentin-containing Tooth Response To Ethanol Bud Outgrowth Involved In Lung Branching Mesenchymal-epithelial Cell Signaling Involved In Prostate Gland Development Prostate Gland Epithelium Morphogenesis Cellular Response To Retinoic Acid Cellular Response To Vitamin D Response To Fibroblast Growth Factor Cellular Response To Prostaglandin D Stimulus	Cell Adhesion Notch Signaling Pathway Axon Guidance Positive Regulation Of Gene Expression Positive Regulation Of Sodium Ion Transport Positive Regulation Of Neuron Projection Development Cerebellum Development
Pathways		Syndecan interactions ECM proteoglycans Integrin cell surface interactions Non-integrin membrane-ECM interactions	Signaling by NOTCH1 HD Domain Mutants in Cancer Axon guidance Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH L1CAM interactions NOTCH2 Activation and Transmission of Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH2 Neurofascin interactions Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Prostate cancer (gene x gene interaction) ( 22219177)	Protein quantitative trait loci ( 18464913)
Protein-Protein Interactions		6 interactors: CNTN1 EGFR FN1 ITGA5 NCAN PTPRB	12 interactors: CNTN2 FYN L1CAM MAPK6 NOTCH1 NOTCH2 PPP1CA PRNP PTPRB SCNN1B TNC TNR
Entrez ID		3371	1272
HPRD ID		01756	07189
Ensembl ID		ENSG00000041982	ENSG00000018236
Uniprot IDs		B4E1W8 P24821 Q4LE33	Q12860
PDB IDs		1TEN 2RB8 2RBL	2EE2 3S97
Enriched GO Terms of Interacting Partners?		Cell Morphogenesis Involved In Differentiation Axon Guidance Cell Morphogenesis Anatomical Structure Morphogenesis Cell Adhesion Locomotion Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Movement Of Cell Or Subcellular Component Chemotaxis Generation Of Neurons Neuron Projection Morphogenesis Neurogenesis Cell Development Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis System Development Endodermal Cell Differentiation Neuron Development Nervous System Development Angiogenesis Cell-substrate Junction Assembly Multicellular Organismal Development Neuron Differentiation Extracellular Matrix Organization Extracellular Structure Organization Cell Projection Organization Endoderm Formation Anatomical Structure Development Blood Vessel Morphogenesis Developmental Process Blood Vessel Development Endoderm Development Vasculature Development Alkanesulfonate Metabolic Process Cell Differentiation Formation Of Primary Germ Layer Response To External Stimulus Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Astrocyte Activation Cell Migration Cardiovascular System Development Gastrulation Activation Of Phospholipase A2 Activity Calcium-independent Cell-matrix Adhesion Cell Motility Cell Junction Assembly Regulation Of Peptidyl-tyrosine Phosphorylation	Axon Development Anatomical Structure Morphogenesis Response To External Stimulus Neuron Projection Development Axonogenesis Neuron Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Cell Adhesion Neuron Projection Morphogenesis Neuron Differentiation Cell Projection Organization Cell Development Cell Morphogenesis Involved In Differentiation Axon Guidance System Development Cell Projection Morphogenesis Cell Part Morphogenesis Negative Regulation Of Cell Adhesion Nervous System Development Generation Of Neurons Response To Stimulus Neurogenesis Multicellular Organismal Development Cell Morphogenesis Anatomical Structure Development Response To Growth Factor Chemotaxis Learning Or Memory Interleukin-4 Secretion Notch Signaling Involved In Heart Development Pulmonary Valve Morphogenesis Cognition Locomotion Interleukin-4 Production Positive Regulation Of Signal Transduction Developmental Process Organ Development Regulation Of Signaling Regulation Of Cell-cell Adhesion Cell Migration Response To Ethanol Regulation Of Cell Proliferation Movement Of Cell Or Subcellular Component Learning Cell Motility Forebrain Development Cell Differentiation Single-organism Behavior Notch Receptor Processing Regulation Of Cell Morphogenesis
Tagcloud ?		actual anaerobically analyser automatic avoid bridge calcium capillary cca2 co2 connection eliminated equilibrium erythrocytes formate ica ingestion ionized junction muscular precipitation puncture semi stasis stored tonometer tubes turntable venous	axin2 axonogenesis coding dendritogenesis interplay inverse maintaining maturing microrna micrornas mrnas ncam1 negr1 neurite neurotrophin nrxn1 ontology orchestrated prkcb pruning represented respective rnas sh2b3 synaptogenesis temporally tightly transcriptome verification
Tagcloud (Difference) ?		actual anaerobically analyser automatic avoid bridge calcium capillary cca2 co2 connection eliminated equilibrium erythrocytes formate ica ingestion ionized junction muscular precipitation puncture semi stasis stored tonometer tubes turntable venous	axin2 axonogenesis coding dendritogenesis interplay inverse maintaining maturing microrna micrornas mrnas ncam1 negr1 neurite neurotrophin nrxn1 ontology orchestrated prkcb pruning represented respective rnas sh2b3 synaptogenesis temporally tightly transcriptome verification
Tagcloud (Intersection) ?