TNC and ASTN2

		TNC	ASTN2
Description		tenascin C	astrotactin 2
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GO Annotations	Cellular Component	Extracellular Region Basement Membrane Interstitial Matrix Extracellular Space Endoplasmic Reticulum Lumen Focal Adhesion Membrane Extracellular Matrix Tenascin Complex Extracellular Matrix Of Synaptic Cleft Perisynaptic Extracellular Matrix Glutamatergic Synapse	Cytoplasm Endosome Early Endosome Late Endosome Cell Cortex Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Perikaryon Cell Pole
	Molecular Function	Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Syndecan Binding	Calcium Ion Binding Inositol 1,3,4,5 Tetrakisphosphate Binding Metal Ion Binding
	Biological Process	Regulation Of Cell Growth Osteoblast Differentiation Morphogenesis Of An Epithelium Cell Adhesion Negative Regulation Of Cell Adhesion Neuromuscular Junction Development Positive Regulation Of Cell Population Proliferation Response To Wounding Response To Mechanical Stimulus Positive Regulation Of Gene Expression Peripheral Nervous System Axon Regeneration Regulation Of Cell Adhesion Regulation Of Cell Migration Neuron Projection Development Odontogenesis Of Dentin-containing Tooth Response To Ethanol Regulation Of Inflammatory Response Bud Outgrowth Involved In Lung Branching Mesenchymal-epithelial Cell Signaling Involved In Prostate Gland Development Prostate Gland Epithelium Morphogenesis Cellular Response To Retinoic Acid Cellular Response To Vitamin D Response To Fibroblast Growth Factor Cellular Response To Prostaglandin D Stimulus	Neuron Migration Neuron Cell-cell Adhesion Protein Transport Protein Localization To Cell Surface Establishment Of Body Hair Planar Orientation Negative Regulation Of Protein Localization To Cell Surface
Pathways		Integrin cell surface interactions Syndecan interactions ECM proteoglycans Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Adult body size ( 32376654) Appendicular lean mass ( 33097823) Developmental language disorder (syntactic complexity) ( 27016271) Inflammatory bowel disease ( 23128233) Metabolite levels ( 23823483) Mosquito bite size ( 28199695) Osteoarthritis (hip) ( 30374069) Response to bupropion and depression ( 27622933)	Adverse response to drug ( 30420678) Appendicular lean mass ( 33097823) Attention deficit hyperactivity disorder ( 18839057) Bipolar disorder and schizophrenia ( 20889312) Body mass index ( 28448500 28892062) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Brain morphology (MOSTest) ( 32665545) Breast cancer ( 29059683) Caudal middle frontal gyrus volume ( 31530798) Chronic obstructive pulmonary disease ( 30804561) Dentate gyrus granule cell layer volume ( 30279459) Depression ( 29700475) Drug-induced liver injury (isoniazid-containing anti-tuberculosis drugs) ( 33135175) Economic and political preferences (fairness) ( 22566634) Estimated glomerular filtration rate ( 31152163 31451708 30604766) Estimated glomerular filtration rate in non-diabetics ( 31451708) Feeling guilty ( 29500382) FEV1 ( 30804560) Glomerular filtration rate (creatinine) ( 28452372) Glucose homeostasis traits ( 25524916) Headache ( 29397368) Heel bone mineral density ( 30598549) Heel bone mineral density x serum urate levels interaction ( 34046847) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Hip shape (DXA scan) ( 30320955) Hippocampal subfield CA4 volume ( 30279459) Hippocampal volume ( 22504421) Idiopathic osteonecrosis of the femoral head ( 28000841) Immune response to anthrax vaccine ( 22658931) Lifetime average cigarettes per day in chronic obstructive pulmonary disease ( 21685187) Lung function (FEV1/FVC) ( 28166213 26635082 30804560) Medication use (antimigraine preparations) ( 31015401) Metabolite levels ( 23823483) Migraine ( 22683712 27182965 27322543) Migraine - clinic-based ( 23793025) Migraine without aura ( 27322543 23793025) Multisite chronic pain ( 33830993 31194737) Nonunion in individuals with fractures ( 30680360) Obesity-related traits ( 23251661) Osteoarthritis (hip) ( 30374069 30664745) Peak expiratory flow ( 30804560) PR interval ( 32439900) Pulmonary function (smoking interaction) ( 23284291) Response to antipsychotic treatment ( 20195266) Shoulder impingement or rotator cuff tear ( 33482370) Subiculum volume ( 30279459) Survival in pancreatic cancer ( 28470677) Total hippocampal volume ( 30279459) Transverse temporal cortex volume ( 31530798) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		11 interacting genes: ANXA2 CNTN1 EGFR FN1 ITGA5 MBD1 NCAN PTPRB SMOC1 SMOC2 SPARC	2 interacting genes: CHRM5 DYRK1A
Entrez ID		3371	23245
HPRD ID		01756	12498
Ensembl ID		ENSG00000041982	ENSG00000148219
Uniprot IDs		B4E1W8 J3QSU6 P24821	B3KN99 B7ZKP4 B7ZKP5 O75129 X6R5P2
PDB IDs		1TEN 2RB8 2RBL 5R5T 5R5U 5R5V 5R5W 5R5X 5R5Y 5R5Z 5R60 5R61 5R62 5R63 6BRB 6QNV 8FN8 8FNB	5J67 5J68 5J69
Enriched GO Terms of Interacting Partners?		Basement Membrane Calcium Ion Binding Cell Adhesion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Locomotion Response To Activity Integrin Alpha5-beta1 Complex Regulation Of Developmental Process Cell-matrix Adhesion Response To Muscle Activity Extracellular Matrix Binding Cell-cell Adhesion Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Calcium-independent Cell-matrix Adhesion Angiogenesis Cell-substrate Adhesion Regulation Of Cell Migration Regulation Of Multicellular Organismal Development Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Cell Motility Regulation Of Locomotion CD40 Signaling Pathway Anatomical Structure Formation Involved In Morphogenesis Virus Receptor Activity Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Fibroblast Proliferation Wound Healing, Spreading Of Epidermal Cells Ruffle Membrane Cell Migration Integrin-mediated Signaling Pathway Protease Binding Negative Regulation Of Anoikis Symbiont Entry Into Host Cell Extracellular Space Regulation Of Angiogenesis Regulation Of Vasculature Development Nuclear Matrix Cell Surface Developmental Process Cell Motility Regulation Of Wound Healing Regulation Of Cell Differentiation Regulation Of Anoikis Integrin Complex Regulation Of Neurogenesis Positive Regulation Of Vacuole Organization	Cellular Response To Stress Histone H3T45 Kinase Activity Axon Development Perisynaptic Extracellular Matrix Positive Regulation Of Interleukin-17-mediated Signaling Pathway Actin Ubiquitination Positive Regulation Of Chemokine (C-C Motif) Ligand 20 Production Extracellular Matrix Of Synaptic Cleft Mesenchymal-epithelial Cell Signaling Involved In Prostate Gland Development Protein Localization To Phagocytic Vesicle Tenascin Complex Bud Outgrowth Involved In Lung Branching Syndecan Binding Actin Modification Striated Muscle Myosin Thick Filament CHRAC Leading Strand Elongation G Protein-coupled Acetylcholine Receptor Activity Regulation Of Phosphatidylinositol Dephosphorylation Negative Regulation Of Heterochromatin Formation Regulation Of Neurofibrillary Tangle Assembly Splicing Factor Binding Cellular Response To Prostaglandin D Stimulus Cytosolic Ciliogenesis Epsilon DNA Polymerase Complex Peripheral Nervous System Axon Regeneration Interstitial Matrix Free Ubiquitin Chain Polymerization Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Gastric Acid Secretion Cellular Response To Nutrient Levels Regulation Of Heterochromatin Formation Mesenchymal-epithelial Cell Signaling Transcription Coactivator Activity RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Tat Protein Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Gene Expression Neurofilament Cellular Response To Vitamin D Branch Elongation Of An Epithelium Negative Regulation Of Microtubule Polymerization DNA Strand Elongation Involved In DNA Replication ATAC Complex Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Regulation Of Metabolic Process Response To Stress Regulation Of Cell Growth Axis Elongation
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