TNC and POLE3

		TNC	POLE3
Description		tenascin C	DNA polymerase epsilon 3, accessory subunit
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Interstitial Matrix Extracellular Space Endoplasmic Reticulum Lumen Focal Adhesion Membrane Extracellular Matrix Tenascin Complex Extracellular Matrix Of Synaptic Cleft Perisynaptic Extracellular Matrix Glutamatergic Synapse	Chromatin Nucleus Nucleoplasm Pericentric Heterochromatin Epsilon DNA Polymerase Complex CHRAC ATAC Complex
	Molecular Function	Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Syndecan Binding	DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Chromatin DNA Binding Protein Heterodimerization Activity
	Biological Process	Regulation Of Cell Growth Osteoblast Differentiation Morphogenesis Of An Epithelium Cell Adhesion Negative Regulation Of Cell Adhesion Neuromuscular Junction Development Positive Regulation Of Cell Population Proliferation Response To Wounding Response To Mechanical Stimulus Positive Regulation Of Gene Expression Peripheral Nervous System Axon Regeneration Regulation Of Cell Adhesion Regulation Of Cell Migration Neuron Projection Development Odontogenesis Of Dentin-containing Tooth Response To Ethanol Regulation Of Inflammatory Response Bud Outgrowth Involved In Lung Branching Mesenchymal-epithelial Cell Signaling Involved In Prostate Gland Development Prostate Gland Epithelium Morphogenesis Cellular Response To Retinoic Acid Cellular Response To Vitamin D Response To Fibroblast Growth Factor Cellular Response To Prostaglandin D Stimulus	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication DNA-templated DNA Replication Leading Strand Elongation Regulation Of DNA Replication Nucleosome Assembly Chromatin Remodeling DNA Damage Response Heterochromatin Formation DNA Biosynthetic Process
Pathways		Integrin cell surface interactions Syndecan interactions ECM proteoglycans Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex
Drugs			Cladribine
Diseases
GWAS		Adult body size ( 32376654) Appendicular lean mass ( 33097823) Developmental language disorder (syntactic complexity) ( 27016271) Inflammatory bowel disease ( 23128233) Metabolite levels ( 23823483) Mosquito bite size ( 28199695) Osteoarthritis (hip) ( 30374069) Response to bupropion and depression ( 27622933)
Interacting Genes		11 interacting genes: ANXA2 CNTN1 EGFR FN1 ITGA5 MBD1 NCAN PTPRB SMOC1 SMOC2 SPARC	6 interacting genes: APP CHRAC1 DR1 DRAP1 POLE4 SMARCA5
Entrez ID		3371	54107
HPRD ID		01756	06274
Ensembl ID		ENSG00000041982	ENSG00000148229
Uniprot IDs		B4E1W8 J3QSU6 P24821	Q9NRF9
PDB IDs		1TEN 2RB8 2RBL 5R5T 5R5U 5R5V 5R5W 5R5X 5R5Y 5R5Z 5R60 5R61 5R62 5R63 6BRB 6QNV 8FN8 8FNB
Enriched GO Terms of Interacting Partners?		Basement Membrane Calcium Ion Binding Cell Adhesion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Locomotion Response To Activity Integrin Alpha5-beta1 Complex Regulation Of Developmental Process Cell-matrix Adhesion Response To Muscle Activity Extracellular Matrix Binding Cell-cell Adhesion Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Calcium-independent Cell-matrix Adhesion Angiogenesis Cell-substrate Adhesion Regulation Of Cell Migration Regulation Of Multicellular Organismal Development Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Cell Motility Regulation Of Locomotion CD40 Signaling Pathway Anatomical Structure Formation Involved In Morphogenesis Virus Receptor Activity Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Fibroblast Proliferation Wound Healing, Spreading Of Epidermal Cells Ruffle Membrane Cell Migration Integrin-mediated Signaling Pathway Protease Binding Negative Regulation Of Anoikis Symbiont Entry Into Host Cell Extracellular Space Regulation Of Angiogenesis Regulation Of Vasculature Development Nuclear Matrix Cell Surface Developmental Process Cell Motility Regulation Of Wound Healing Regulation Of Cell Differentiation Regulation Of Anoikis Integrin Complex Regulation Of Neurogenesis Positive Regulation Of Vacuole Organization	Negative Cofactor 2 Complex Protein Heterodimerization Activity CHRAC Regulation Of Proteolysis Epsilon DNA Polymerase Complex Protein-containing Complex Assembly Protein-containing Complex Organization Response To Peptide Response To Cytokine ATAC Complex Response To Lead Ion Ficolin-1-rich Granule Lumen Regulation Of Protein Catabolic Process Regulation Of Macromolecule Metabolic Process DNA-directed DNA Polymerase Activity TBP-class Protein Binding Amyloid Fibril Formation Pericentric Heterochromatin Regulation Of Primary Metabolic Process Porphobilinogen Synthase Activity Proteasome Core Complex Binding Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Response To Mechanical Stimulus Regulation Of Cell Cycle Negative Regulation Of Collagen Catabolic Process Negative Regulation Of Elastin Catabolic Process Protein-DNA Complex Assembly RNA Polymerase II General Transcription Initiation Factor Activity Regulation Of Plasma Membrane Raft Polarization Phosphatidylinositol 3-kinase Catalytic Subunit Binding Perisynaptic Extracellular Matrix Positive Regulation Of Interleukin-17-mediated Signaling Pathway Actin Ubiquitination Positive Regulation Of Chemokine (C-C Motif) Ligand 20 Production DNA-templated DNA Replication Cellular Component Assembly Regulation Of Growth Axon Development Regulation Of Cellular Component Organization Response To Vitamin Acetylcholine Receptor Activator Activity Immune Response Innate Immune Response
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