CRYAB and APOC2

Number of citations of the paper that reports this interaction (PMID 23159935)
2

Data Source:
BioGRID (pull down)

		CRYAB	APOC2
Gene Name		crystallin, alpha B	apolipoprotein C-II
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Golgi Apparatus Cytosol Plasma Membrane Cell Surface Microtubule Cytoskeleton Z Disc Actin Filament Bundle Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Early Endosome Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle Intermediate-density Lipoprotein Particle Spherical High-density Lipoprotein Particle Chylomicron Extracellular Vesicular Exosome
	Molecular Function	Structural Constituent Of Eye Lens Protein Binding Microtubule Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Unfolded Protein Binding	Lipid Binding Phospholipase Activator Activity Protein Homodimerization Activity Phospholipase Binding Lipase Inhibitor Activity Lipoprotein Lipase Activator Activity
	Biological Process	Response To Hypoxia Lens Development In Camera-type Eye Protein Folding Muscle Contraction Tubulin Complex Assembly Muscle Organ Development Aging Regulation Of Cell Death Negative Regulation Of Cell Growth Microtubule Polymerization Or Depolymerization Response To Estradiol Negative Regulation Of Intracellular Transport Response To Hydrogen Peroxide Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Homooligomerization Stress-activated MAPK Cascade Apoptotic Process Involved In Morphogenesis Cellular Response To Gamma Radiation Negative Regulation Of Reactive Oxygen Species Metabolic Process	Retinoid Metabolic Process Phototransduction, Visible Light Positive Regulation Of Phospholipase Activity Positive Regulation Of Triglyceride Catabolic Process Positive Regulation Of Very-low-density Lipoprotein Particle Remodeling Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Lipid Catabolic Process Negative Regulation Of Cholesterol Transport Cholesterol Efflux Phospholipid Efflux Triglyceride-rich Lipoprotein Particle Remodeling Chylomicron Remodeling Very-low-density Lipoprotein Particle Remodeling Chylomicron Remnant Clearance High-density Lipoprotein Particle Clearance Lipoprotein Metabolic Process Cholesterol Homeostasis Negative Regulation Of Catalytic Activity Reverse Cholesterol Transport Small Molecule Metabolic Process Positive Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Lipid Metabolic Process Negative Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Lipoprotein Lipase Activity Positive Regulation Of Phospholipid Catabolic Process Triglyceride Homeostasis
Pathways			Lipoprotein metabolism HDL-mediated lipid transport Visual phototransduction Metabolism of lipids and lipoproteins Chylomicron-mediated lipid transport Lipid digestion, mobilization, and transport Diseases associated with visual transduction Retinoid metabolism and transport
Drugs
Diseases
GWAS			Cholesterol, total ( 20686565) HDL cholesterol ( 20686565) LDL cholesterol ( 18802019 18193044 20864672 19060906 20686565) Lipid metabolism phenotypes ( 22286219) Quantitative traits ( 19197348) Triglycerides ( 20686565)
Protein-Protein Interactions		44 interactors: ACOT7 APOC2 APP AVP B2M BAG3 BCL2L1 BMPR2 CASP3 CCL22 CCND1 CRYAA CRYBA1 CRYBB2 CRYGC CRYGD CS DDX20 DES EPB41 FCGR2A FGF2 GFAP HBA1 HSPB1 HSPB2 HSPB8 INS KRTAP19-5 KRTAP8-1 LALBA MDH2 MIP MRPL11 NGF PRKAG3 PSMA3 SNCA SOD1 TNPO2 TRAPPC6A TTN UBE2D1 VEGFA	2 interactors: CRYAB LPL
Entrez ID		1410	344
HPRD ID		00428	07457
Ensembl ID		ENSG00000109846	ENSG00000234906
Uniprot IDs		P02511	P02655
PDB IDs		2KLR 2WJ7 2Y1Y 2Y1Z 2Y22 2YGD 3L1G 3SGM 3SGN 3SGO 3SGP 3SGR 3SGS	1BY6 1I5J 1O8T 1SOH
Enriched GO Terms of Interacting Partners?		Response To Stress Negative Regulation Of Cell Death Positive Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Cell Death Response To External Stimulus Negative Regulation Of Apoptotic Process Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Regulation Of Phosphorus Metabolic Process Regulation Of Phosphorylation Response To Abiotic Stimulus Positive Regulation Of Protein Modification Process Positive Regulation Of Endothelial Cell Chemotaxis Positive Regulation Of Transferase Activity Regulation Of Cellular Protein Metabolic Process Visual Perception Sensory Perception Of Light Stimulus Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Regulation Of Lipid Metabolic Process Response To Stimulus Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Cellular Response To Oxidative Stress Regulation Of Proteolysis Regulation Of Protein Metabolic Process Positive Regulation Of Cell Growth Positive Regulation Of Growth Response To Wounding Neuron Apoptotic Process Camera-type Eye Development Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Protein Phosphorylation Regulation Of Neuron Apoptotic Process Regulation Of Lipid Biosynthetic Process Organ Development Neuron Death Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Eye Development Programmed Cell Death Sensory Organ Development Response To Oxidative Stress Platelet Degranulation Sensory Perception	Chylomicron Remodeling Response To Radiation Positive Regulation Of Sequestering Of Triglyceride Tubulin Complex Assembly Very-low-density Lipoprotein Particle Remodeling Triglyceride-rich Lipoprotein Particle Remodeling Positive Regulation Of Cholesterol Storage Triglyceride Catabolic Process Apoptotic Process Involved In Morphogenesis Cellular Response To Gamma Radiation Acylglycerol Catabolic Process Apoptotic Process Involved In Development Response To Abiotic Stimulus Plasma Lipoprotein Particle Remodeling Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Lipid Storage Triglyceride Homeostasis Developmental Programmed Cell Death Microtubule Polymerization Or Depolymerization Acylglycerol Homeostasis Negative Regulation Of Reactive Oxygen Species Metabolic Process Triglyceride Biosynthetic Process Regulation Of Macrophage Derived Foam Cell Differentiation Response To Gamma Radiation Response To Cold Regulation Of Lipid Storage Cellular Response To Ionizing Radiation Regulation Of Plasma Lipoprotein Particle Levels Phototransduction, Visible Light Retinoid Metabolic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Diterpenoid Metabolic Process Detection Of Visible Light Triglyceride Metabolic Process Lens Development In Camera-type Eye Phototransduction Neutral Lipid Metabolic Process Detection Of Light Stimulus Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Lipid Homeostasis Negative Regulation Of Intracellular Transport Response To Estradiol Response To Hydrogen Peroxide Isoprenoid Metabolic Process Fatty Acid Biosynthetic Process Cellular Response To Radiation Response To Ionizing Radiation Cellular Lipid Catabolic Process
Tagcloud ?		adaptive aggregated antiapoptotic assisting cardiomyocyte cardiomyocytes chaperons confers correct crystallin elicit emphasizing folding hsp hsps interplay lumen mini misfolded mitigate myocardium myocytes referred stressed stresses undergo unfolded upr worldwide	atp1a3 bckdha cgb cgm2 cyp2a d19s112 d19s116 d19s117 d19s118 d19s119 d19s19 d19s2 d19s37 d19s50 d19s51 d19s54 d19s55 d19s6 d19s62 d19s63 d19s7 d19s8 d19s9 manb pepd prkcg psg1 pw39 tnnt1
Tagcloud (Difference) ?		adaptive aggregated antiapoptotic assisting cardiomyocyte cardiomyocytes chaperons confers correct crystallin elicit emphasizing folding hsp hsps interplay lumen mini misfolded mitigate myocardium myocytes referred stressed stresses undergo unfolded upr worldwide	atp1a3 bckdha cgb cgm2 cyp2a d19s112 d19s116 d19s117 d19s118 d19s119 d19s19 d19s2 d19s37 d19s50 d19s51 d19s54 d19s55 d19s6 d19s62 d19s63 d19s7 d19s8 d19s9 manb pepd prkcg psg1 pw39 tnnt1
Tagcloud (Intersection) ?