CRYAB and CRYGS

Number of citations of the paper that reports this interaction (PubMedID 24183572)
45

Data Source:
BioGRID (pull down)

		CRYAB	CRYGS
Description		crystallin alpha B	crystallin gamma S
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Lysosome Cytosol Plasma Membrane Cell Surface Z Disc Axon M Band I Band Actin Filament Bundle Protein-containing Complex Dendritic Spine Perikaryon Contractile Muscle Fiber Extracellular Exosome Synaptic Membrane Cardiac Myofibril
	Molecular Function	Amyloid-beta Binding Structural Molecule Activity Structural Constituent Of Eye Lens Protein Binding Microtubule Binding Cytoskeletal Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Metal Ion Binding Unfolded Protein Binding	Structural Constituent Of Eye Lens Protein Binding
	Biological Process	Response To Hypoxia Lens Development In Camera-type Eye Protein Folding Muscle Contraction Tubulin Complex Assembly Muscle Organ Development Response To Heat Negative Regulation Of Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Cell Growth Microtubule Polymerization Or Depolymerization Negative Regulation Of Protein-containing Complex Assembly Response To Estradiol Negative Regulation Of Intracellular Transport Protein Refolding Response To Hydrogen Peroxide Camera-type Eye Development Negative Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Negative Regulation Of DNA-templated Transcription Protein Stabilization Stress-activated MAPK Cascade Apoptotic Process Involved In Morphogenesis Cellular Response To Gamma Radiation Negative Regulation Of Amyloid Fibril Formation Negative Regulation Of Reactive Oxygen Species Metabolic Process	Morphogenesis Of An Epithelium Lens Development In Camera-type Eye Visual Perception
Pathways		HSF1-dependent transactivation
Drugs
Diseases		Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM)
GWAS		Birth weight ( 31043758) Hip circumference adjusted for BMI ( 34021172) PR interval ( 32439900)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Glaucoma (primary open-angle) ( 29449654) Illicit drug use ( 23942779) Open-angle glaucoma and vertical cup-disc ratio ( 29449654)
Interacting Genes		57 interacting genes: - ACOT7 APOC2 APP AVP B2M BAG3 BCL2L1 BMPR2 CAPN3 CASP3 CCL22 CCND1 CRYAA CRYBA1 CRYBB2 CRYGC CRYGD CRYGS CS DDX20 DES EPB41 FCGR2A FGF2 GFAP GORASP2 HBA1 HSPB1 HSPB2 HSPB6 HSPB8 INS KRTAP19-5 KRTAP6-1 KRTAP8-1 LALBA LBH MDH2 MIP MRPL11 NGF PRKAG3 PRNP PSMA3 RBM11 SCN5A SLC13A1 SNCA SOD1 SQSTM1 TIAM1 TNPO2 TRAPPC6A TTN UBE2D1 VEGFA	4 interacting genes: CRYAB POT1 TERF2IP TINF2
Entrez ID		1410	1427
HPRD ID		00428	00439
Ensembl ID		ENSG00000109846	ENSG00000213139
Uniprot IDs		A0A024R3B9 P02511 V9HW27	A0A140CTX8 P22914
PDB IDs		2KLR 2N0K 2WJ7 2Y1Y 2Y1Z 2Y22 2YGD 3J07 3L1G 3SGM 3SGN 3SGO 3SGP 3SGR 3SGS 4M5S 4M5T 5VVV 6BP9 7ROJ 9BEE	1HA4 2M3T 2M3U 6FD8 6IF9 7N36 7N37 7N38 7N39 7N3A 7N3B 7NJE
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Eye Lens Lens Development In Camera-type Eye Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Response To Stress Negative Regulation Of Programmed Cell Death Regulation Of Neuron Apoptotic Process Negative Regulation Of Apoptotic Process Identical Protein Binding System Process Protein Refolding Regulation Of Transport Response To Metal Ion Regulation Of Autophagy Response To Heat Sensory Perception Regulation Of Multicellular Organismal Process Nervous System Process Apoptotic Process Programmed Cell Death Cellular Response To Metal Ion Positive Regulation Of Growth Cell Death Response To Oxidative Stress Visual Perception Sensory Perception Of Light Stimulus Regulation Of Growth Response To Copper Ion Regulation Of Cell Population Proliferation Positive Regulation Of Multicellular Organismal Process Z Disc Neuron Projection Maintenance Regulation Of Dendritic Spine Maintenance Cellular Response To Stress Response To Unfolded Protein Positive Regulation Of Apoptotic Process Response To Temperature Stimulus Positive Regulation Of Endothelial Cell Chemotaxis Regulation Of Long-term Synaptic Potentiation Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Programmed Cell Death Positive Regulation Of Small Molecule Metabolic Process Positive Regulation Of Endocytosis Cytosol Positive Regulation Of Transport Positive Regulation Of Protein Localization Response To Reactive Oxygen Species Positive Regulation Of Cell Growth Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Ovarian Follicle Development	Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Telomere Assembly Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Telomere Maintenance Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Telomere Organization Negative Regulation Of DNA Metabolic Process G-rich Strand Telomeric DNA Binding Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Cellular Component Organization Chromosome, Telomeric Region Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase Regulation Of Chromosome Organization RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Positive Regulation Of DNA Metabolic Process Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Chromosome Organization Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA Metabolic Process Positive Regulation Of Organelle Organization Regulation Of DNA Biosynthetic Process DNA Biosynthetic Process Positive Regulation Of DNA Strand Elongation Chromosome Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Protein Localization To Chromosome DNA Metabolic Process Regulation Of Cellular Component Organization Positive Regulation Of Telomeric Loop Disassembly Regulation Of Double-strand Break Repair Perinucleolar Chromocenter Negative Regulation Of DNA Recombination At Telomere Organelle Organization Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Telomeric D-loop Binding
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