CRYAB and HSPB6

Number of citations of the paper that reports this interaction (PubMedID 28919577)
0

Data Source:
BioGRID (pull down)

		CRYAB	HSPB6
Description		crystallin alpha B	heat shock protein family B (small) member 6
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Lysosome Cytosol Plasma Membrane Cell Surface Z Disc Axon M Band I Band Actin Filament Bundle Protein-containing Complex Dendritic Spine Perikaryon Contractile Muscle Fiber Extracellular Exosome Synaptic Membrane Cardiac Myofibril	Extracellular Region Nucleus Cytoplasm Mitochondrion Cytosol Nuclear Speck
	Molecular Function	Amyloid-beta Binding Structural Molecule Activity Structural Constituent Of Eye Lens Protein Binding Microtubule Binding Cytoskeletal Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Metal Ion Binding Unfolded Protein Binding	Structural Constituent Of Eye Lens Protein Kinase Binding Protein Homodimerization Activity Protein Folding Chaperone Unfolded Protein Binding Protein-folding Chaperone Binding
	Biological Process	Response To Hypoxia Lens Development In Camera-type Eye Protein Folding Muscle Contraction Tubulin Complex Assembly Muscle Organ Development Response To Heat Negative Regulation Of Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Cell Growth Microtubule Polymerization Or Depolymerization Negative Regulation Of Protein-containing Complex Assembly Response To Estradiol Negative Regulation Of Intracellular Transport Protein Refolding Response To Hydrogen Peroxide Camera-type Eye Development Negative Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Negative Regulation Of DNA-templated Transcription Protein Stabilization Stress-activated MAPK Cascade Apoptotic Process Involved In Morphogenesis Cellular Response To Gamma Radiation Negative Regulation Of Amyloid Fibril Formation Negative Regulation Of Reactive Oxygen Species Metabolic Process	Protein Folding Response To Heat Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Protein Refolding Negative Regulation Of Apoptotic Process Positive Regulation Of Angiogenesis
Pathways		HSF1-dependent transactivation
Drugs
Diseases		Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM)
GWAS		Birth weight ( 31043758) Hip circumference adjusted for BMI ( 34021172) PR interval ( 32439900)	Brain morphology (MOSTest) ( 32665545)
Interacting Genes		57 interacting genes: - ACOT7 APOC2 APP AVP B2M BAG3 BCL2L1 BMPR2 CAPN3 CASP3 CCL22 CCND1 CRYAA CRYBA1 CRYBB2 CRYGC CRYGD CRYGS CS DDX20 DES EPB41 FCGR2A FGF2 GFAP GORASP2 HBA1 HSPB1 HSPB2 HSPB6 HSPB8 INS KRTAP19-5 KRTAP6-1 KRTAP8-1 LALBA LBH MDH2 MIP MRPL11 NGF PRKAG3 PRNP PSMA3 RBM11 SCN5A SLC13A1 SNCA SOD1 SQSTM1 TIAM1 TNPO2 TRAPPC6A TTN UBE2D1 VEGFA	6 interacting genes: BECN1 CRYAB HSPB8 SNCA YWHAG YWHAZ
Entrez ID		1410	126393
HPRD ID		00428	08130
Ensembl ID		ENSG00000109846	ENSG00000004776
Uniprot IDs		A0A024R3B9 P02511 V9HW27	O14558 V9HWB6
PDB IDs		2KLR 2N0K 2WJ7 2Y1Y 2Y1Z 2Y22 2YGD 3J07 3L1G 3SGM 3SGN 3SGO 3SGP 3SGR 3SGS 4M5S 4M5T 5VVV 6BP9 7ROJ 9BEE	4JUS 4JUT 5LTW 5LU1 5LU2 5LUM 5OK9 5OKF
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Eye Lens Lens Development In Camera-type Eye Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Response To Stress Negative Regulation Of Programmed Cell Death Regulation Of Neuron Apoptotic Process Negative Regulation Of Apoptotic Process Identical Protein Binding System Process Protein Refolding Regulation Of Transport Response To Metal Ion Regulation Of Autophagy Response To Heat Sensory Perception Regulation Of Multicellular Organismal Process Nervous System Process Apoptotic Process Programmed Cell Death Cellular Response To Metal Ion Positive Regulation Of Growth Cell Death Response To Oxidative Stress Visual Perception Sensory Perception Of Light Stimulus Regulation Of Growth Response To Copper Ion Regulation Of Cell Population Proliferation Positive Regulation Of Multicellular Organismal Process Z Disc Neuron Projection Maintenance Regulation Of Dendritic Spine Maintenance Cellular Response To Stress Response To Unfolded Protein Positive Regulation Of Apoptotic Process Response To Temperature Stimulus Positive Regulation Of Endothelial Cell Chemotaxis Regulation Of Long-term Synaptic Potentiation Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Programmed Cell Death Positive Regulation Of Small Molecule Metabolic Process Positive Regulation Of Endocytosis Cytosol Positive Regulation Of Transport Positive Regulation Of Protein Localization Response To Reactive Oxygen Species Positive Regulation Of Cell Growth Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Ovarian Follicle Development	Cellular Response To Stress Protein Sequestering Activity Cellular Response To Glucose Starvation Identical Protein Binding Response To Iron(II) Ion Regulation Of Protein Stability Regulation Of Lysosome Organization Cellular Response To Copper Ion Cellular Response To Starvation Protein Targeting Response To Stress Protein Domain Specific Binding Response To Starvation MAPK Cascade Response To Iron Ion Response To Copper Ion Cellular Response To Nutrient Levels Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Response To Oxidative Stress Regulation Of Autophagy Protein Localization To Lysosome Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation Negative Regulation Of TORC1 Signaling TORC1 Signaling Lysosome Organization Regulation Of Vacuole Organization Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Organelle Localization Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission TOR Signaling Cellular Response To Aluminum Ion Protein Localization To Vacuole Response To Nutrient Levels Negative Regulation Of TOR Signaling Regulation Of TORC1 Signaling Positive Regulation Of Macroautophagy Response To Hydrogen Peroxide Negative Regulation Of Metabolic Process Negative Regulation Of Autophagy Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Catabolic Process Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process
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