CRYAB and NGF

Number of citations of the paper that reports this interaction (PMID 17487982)
27

Data Source:
BioGRID (unspecified method)

		CRYAB	NGF
Gene Name		crystallin, alpha B	nerve growth factor (beta polypeptide)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Golgi Apparatus Cytosol Plasma Membrane Cell Surface Microtubule Cytoskeleton Z Disc Actin Filament Bundle Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Endosome Golgi Lumen Cytoplasmic Membrane-bounded Vesicle
	Molecular Function	Structural Constituent Of Eye Lens Protein Binding Microtubule Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Unfolded Protein Binding	Receptor Signaling Protein Activity Nerve Growth Factor Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Response To Hypoxia Lens Development In Camera-type Eye Protein Folding Muscle Contraction Tubulin Complex Assembly Muscle Organ Development Aging Regulation Of Cell Death Negative Regulation Of Cell Growth Microtubule Polymerization Or Depolymerization Response To Estradiol Negative Regulation Of Intracellular Transport Response To Hydrogen Peroxide Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Homooligomerization Stress-activated MAPK Cascade Apoptotic Process Involved In Morphogenesis Cellular Response To Gamma Radiation Negative Regulation Of Reactive Oxygen Species Metabolic Process	Activation Of MAPKK Activity Inflammatory Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Activation Of Phospholipase C Activity Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Cell-cell Signaling Peripheral Nervous System Development Memory Circadian Rhythm Adult Locomotory Behavior Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Response To Radiation Response To Mechanical Stimulus Response To Ozone Positive Regulation Of Gene Expression Positive Regulation Of Neuron Maturation Sensory Perception Of Pain Positive Regulation Of Protein Autophosphorylation Nerve Growth Factor Processing Response To Lipopolysaccharide Response To Nicotine Nerve Growth Factor Signaling Pathway Response To Drug Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Peptide Hormone Negative Regulation Of Neuron Apoptotic Process Regulation Of Neuron Differentiation Positive Regulation Of Axon Extension Negative Regulation Of Cell Cycle Regulation Of Neurotransmitter Secretion Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Neuron Projection Morphogenesis Regulation Of Axonogenesis Positive Regulation Of Axonogenesis Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Response To Glucocorticoid Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Neuron Apoptotic Process Response To Electrical Stimulus Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Stem Cell Proliferation Negative Regulation Of Type B Pancreatic Cell Apoptotic Process
Pathways			Retrograde neurotrophin signalling Signalling to ERKs Prolonged ERK activation events NF-kB is activated and signals survival p75NTR recruits signalling complexes Axonal growth stimulation Ceramide signalling PI3K/AKT activation p75NTR signals via NF-kB NGF processing NFG and proNGF binds to p75NTR Signalling to p38 via RIT and RIN Signalling by NGF p75NTR regulates axonogenesis p75NTR negatively regulates cell cycle via SC1 Cell death signalling via NRAGE, NRIF and NADE Activation of TRKA receptors p75 NTR receptor-mediated signalling NGF signalling via TRKA from the plasma membrane ARMS-mediated activation TRKA activation by NGF NRIF signals cell death from the nucleus Signalling to RAS NRAGE signals death through JNK Signalling to STAT3 PLC-gamma1 signalling NADE modulates death signalling Frs2-mediated activation
Drugs			Clenbuterol
Diseases
GWAS			Non-alcoholic fatty liver disease ( 23535911)
Protein-Protein Interactions		44 interactors: ACOT7 APOC2 APP AVP B2M BAG3 BCL2L1 BMPR2 CASP3 CCL22 CCND1 CRYAA CRYBA1 CRYBB2 CRYGC CRYGD CS DDX20 DES EPB41 FCGR2A FGF2 GFAP HBA1 HSPB1 HSPB2 HSPB8 INS KRTAP19-5 KRTAP8-1 LALBA MDH2 MIP MRPL11 NGF PRKAG3 PSMA3 SNCA SOD1 TNPO2 TRAPPC6A TTN UBE2D1 VEGFA	8 interactors: A2M CRYAB MMP7 NGFR NTRK1 PLG SORCS3 SORT1
Entrez ID		1410	4803
HPRD ID		00428	08874
Ensembl ID		ENSG00000109846	ENSG00000134259
Uniprot IDs		P02511	P01138
PDB IDs		2KLR 2WJ7 2Y1Y 2Y1Z 2Y22 2YGD 3L1G 3SGM 3SGN 3SGO 3SGP 3SGR 3SGS	1SG1 1WWW 2IFG
Enriched GO Terms of Interacting Partners?		Response To Stress Negative Regulation Of Cell Death Positive Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Cell Death Response To External Stimulus Negative Regulation Of Apoptotic Process Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Regulation Of Phosphorus Metabolic Process Regulation Of Phosphorylation Response To Abiotic Stimulus Positive Regulation Of Protein Modification Process Positive Regulation Of Endothelial Cell Chemotaxis Positive Regulation Of Transferase Activity Regulation Of Cellular Protein Metabolic Process Visual Perception Sensory Perception Of Light Stimulus Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Regulation Of Lipid Metabolic Process Response To Stimulus Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Cellular Response To Oxidative Stress Regulation Of Proteolysis Regulation Of Protein Metabolic Process Positive Regulation Of Cell Growth Positive Regulation Of Growth Response To Wounding Neuron Apoptotic Process Camera-type Eye Development Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Protein Phosphorylation Regulation Of Neuron Apoptotic Process Regulation Of Lipid Biosynthetic Process Organ Development Neuron Death Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Eye Development Programmed Cell Death Sensory Organ Development Response To Oxidative Stress Platelet Degranulation Sensory Perception	Extracellular Matrix Disassembly Nerve Growth Factor Signaling Pathway Cellular Response To Nerve Growth Factor Stimulus Detection Of Temperature Stimulus Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Developmental Programmed Cell Death Cell Differentiation Extracellular Matrix Organization Programmed Cell Death Extracellular Structure Organization Response To Stimulus Regulation Of Endopeptidase Activity Cell Death Death Negative Regulation Of Hydrolase Activity Platelet Degranulation Regulation Of Peptidase Activity Antibacterial Peptide Secretion Antibacterial Peptide Biosynthetic Process Neuropeptide Signaling Pathway Regulation Of Catalytic Activity Nerve Development Muscle Structure Development Negative Regulation Of Complement Activation, Lectin Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Cell Proliferation Secretion Regulation Of Long Term Synaptic Depression Mononuclear Cell Migration Negative Regulation Of Hair Follicle Development Regulation Of Proteolysis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation Response To Wounding Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Hair Cycle Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Fibrinolysis Circadian Rhythm Detection Of Abiotic Stimulus Negative Regulation Of Catalytic Activity Response To Temperature Stimulus Platelet Activation Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Endosome Transport Via Multivesicular Body Sorting Pathway Regulation Of Cysteine-type Endopeptidase Activity Signal Transduction Axonogenesis Involved In Innervation
Tagcloud ?		adaptive aggregated antiapoptotic assisting cardiomyocyte cardiomyocytes chaperons confers correct crystallin elicit emphasizing folding hsp hsps interplay lumen mini misfolded mitigate myocardium myocytes referred stressed stresses undergo unfolded upr worldwide	afferent antagonist b1 b2 bk blocked cap capsaicin completely cultivation cultured depolarization depolarized dissociated dorsal drg drgs freshly ganglia insensitive microm nerve neurons percentage rat recordings root sensitive small
Tagcloud (Difference) ?		adaptive aggregated antiapoptotic assisting cardiomyocyte cardiomyocytes chaperons confers correct crystallin elicit emphasizing folding hsp hsps interplay lumen mini misfolded mitigate myocardium myocytes referred stressed stresses undergo unfolded upr worldwide	afferent antagonist b1 b2 bk blocked cap capsaicin completely cultivation cultured depolarization depolarized dissociated dorsal drg drgs freshly ganglia insensitive microm nerve neurons percentage rat recordings root sensitive small
Tagcloud (Intersection) ?