GRIN1 and MYH9

Number of citations of the paper that reports this interaction (PMID 10862698)
203

Data Source:
HPRD (in vivo)

		GRIN1	MYH9
Gene Name		glutamate receptor, ionotropic, N-methyl D-aspartate 1	myosin, heavy chain 9, non-muscle
Image
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle Cell Surface Postsynaptic Density N-methyl-D-aspartate Selective Glutamate Receptor Complex Cell Junction Dendrite Dendrite Membrane Neuron Projection Synaptic Cleft Terminal Bouton Dendritic Spine Synapse Postsynaptic Membrane Excitatory Synapse Neuronal Postsynaptic Density	Stress Fiber Ruffle Immunological Synapse Uropod Nucleus Cytoplasm Spindle Actomyosin Contractile Ring Cytosol Plasma Membrane Cell-cell Adherens Junction COP9 Signalosome Integrin Complex Actin Cytoskeleton Membrane Myosin II Complex Cortical Cytoskeleton Cell Leading Edge Neuromuscular Junction Cleavage Furrow Actomyosin Protein Complex Extracellular Vesicular Exosome Myosin II Filament
	Molecular Function	N-methyl-D-aspartate Selective Glutamate Receptor Activity Extracellular-glutamate-gated Ion Channel Activity Calcium Channel Activity Calcium Ion Binding Protein Binding Calmodulin Binding Glycine Binding Glutamate Binding Enzyme Binding Voltage-gated Cation Channel Activity Glutamate Receptor Binding Neurotransmitter Binding Protein Heterodimerization Activity	Microfilament Motor Activity Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding ATPase Activity Actin-dependent ATPase Activity Protein Homodimerization Activity Protein Anchor ADP Binding Poly(A) RNA Binding Actin Filament Binding
	Biological Process	Conditioned Taste Aversion Suckling Behavior Response To Amphetamine Cation Transport Cellular Calcium Ion Homeostasis Synaptic Transmission Axon Guidance Respiratory Gaseous Exchange Long-term Memory Adult Locomotory Behavior Olfactory Learning Visual Learning Propylene Metabolic Process Sensory Perception Of Pain Pons Maturation Cerebral Cortex Development Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Social Behavior Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Membrane Potential Positive Regulation Of Apoptotic Process Response To Morphine Negative Regulation Of Neuron Apoptotic Process Regulation Of Respiratory Gaseous Exchange Response To Ethanol Positive Regulation Of Transcription From RNA Polymerase II Promoter Ephrin Receptor Signaling Pathway Regulation Of Long-term Neuronal Synaptic Plasticity Rhythmic Process Regulation Of Dendrite Morphogenesis Regulation Of Axonogenesis Protein Tetramerization Response To Calcium Ion Regulation Of Synapse Assembly Calcium Ion Homeostasis Regulation Of Excitatory Postsynaptic Membrane Potential Prepulse Inhibition Male Mating Behavior Response To Fungicide Calcium Ion Transmembrane Transport Cellular Response To Manganese Ion Positive Regulation Of Excitatory Postsynaptic Membrane Potential	Meiotic Spindle Organization Cytokinesis Angiogenesis In Utero Embryonic Development Establishment Of T Cell Polarity Membrane Protein Ectodomain Proteolysis Integrin-mediated Signaling Pathway Axon Guidance Myoblast Fusion Regulation Of Cell Shape Protein Transport Actin Filament-based Movement Platelet Formation Monocyte Differentiation Actomyosin Structure Organization Actin Cytoskeleton Reorganization Uropod Organization Termination Of G-protein Coupled Receptor Signaling Pathway Blood Vessel Endothelial Cell Migration Ephrin Receptor Signaling Pathway Leukocyte Migration Establishment Of Meiotic Spindle Localization Platelet Aggregation
Pathways		EPHB-mediated forward signaling Axon guidance Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII EPH-Ephrin signaling CREB phosphorylation through the activation of Ras Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Unblocking of NMDA receptor, glutamate binding and activation Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses	EPHA-mediated growth cone collapse Axon guidance Semaphorin interactions EPH-Ephrin signaling Sema4D in semaphorin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Sema4D induced cell migration and growth-cone collapse Innate Immune System
Drugs		L-Glutamic Acid Meperidine Orphenadrine Dcka, 5,7-Dichlorokynurenic Acid D-Serine Cycloleucine Milnacipran Agmatine
Diseases
GWAS		Post-traumatic stress disorder (asjusted for relatedness) ( 23726511)	End-stage renal disease (non-diabetic) ( 20532800) Glomerulosclerosis ( 20668430) Optic disc size (rim) ( 20395239)
Protein-Protein Interactions		53 interactors: ACTN2 AKAP9 CALM1 CAMK2A CAMK2G CANX CDH2 CIT CLTC CTNNB1 DLG2 DLG3 DLG4 DLGAP4 DNM1 DRD1 DUSP4 EPHB2 EPHB4 FUS FYN GRIN2A GRIN2B GRIN2D GRIN3A HNRNPU HRAS HSPA1A INA LNX1 LRP8 MAP2 MAP2K2 MYH9 NANOS1 NEFL NF1 PLAT PLCG1 PPP2R1A PPP2R2A PRKCA PRKCB PRKCE PRKCG RAP2A RPS6KA3 SP3 SPTAN1 SYNGAP1 TJP1 TRAF3 TUBA4B	22 interactors: ASCC2 CASP4 CBL CD163 CSNK2A1 CXCR4 GRB2 GRIN1 MEN1 MYBPC3 MYH10 MYL9 MYOM1 MYOM2 OVGP1 PPP2CA PTPN6 RAC1 S100A4 TTN TUFM YWHAZ
Entrez ID		2902	4627
HPRD ID		15926	01177
Ensembl ID		ENSG00000176884	ENSG00000100345
Uniprot IDs		Q05586 Q59GW0 Q5VSF9	P35579
PDB IDs		2HQW 2NR1 3BYA	2LNK 3ZWH 4ETO
Enriched GO Terms of Interacting Partners?		Synaptic Transmission Cell-cell Signaling Nervous System Development Signaling Locomotion Cell Communication Neurogenesis Cell Differentiation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Organic Substance Generation Of Neurons Neuron Projection Development Neuron Development Developmental Process Cell Development Neuron Differentiation Response To External Stimulus Signal Transduction Cell Projection Organization Movement Of Cell Or Subcellular Component Enzyme Linked Receptor Protein Signaling Pathway Multicellular Organismal Development System Development Cellular Response To Stimulus Anatomical Structure Development Axon Development Axon Guidance Regulation Of Synaptic Transmission Regulation Of Synaptic Plasticity Neuron Projection Morphogenesis Cell Surface Receptor Signaling Pathway Axonogenesis Cellular Response To Organic Substance Response To Wounding Cell Morphogenesis Involved In Neuron Differentiation Cell Morphogenesis Involved In Differentiation Learning Response To Stimulus Regulation Of Signaling Chemotaxis Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Response To Abiotic Stimulus Fibroblast Growth Factor Receptor Signaling Pathway Blood Coagulation Hemostasis Cell Projection Morphogenesis Single-organism Behavior Cellular Response To Growth Factor Stimulus Learning Or Memory	Cell Morphogenesis Involved In Differentiation Cell Development Platelet Activation Axon Guidance Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Morphogenesis Movement Of Cell Or Subcellular Component Anatomical Structure Morphogenesis Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Wound Healing Chemotaxis Locomotion Positive Regulation Of Signal Transduction Neuron Projection Morphogenesis Apoptotic Process Muscle Contraction Cell Activation Blood Coagulation Programmed Cell Death Hemostasis Ephrin Receptor Signaling Pathway Response To Wounding Cell Death Death Muscle System Process Neuron Projection Development Cell Projection Morphogenesis Myosin Filament Assembly Cell Part Morphogenesis Regulation Of Body Fluid Levels Cell Differentiation Neuron Development Regulation Of Cellular Component Organization Actin Filament-based Movement Regulation Of Signaling Cell Surface Receptor Signaling Pathway Endomembrane System Organization Neuron Differentiation T Cell Costimulation Myofibril Assembly Leukocyte Migration Brain Development Cell Projection Organization Regulation Of Kinase Activity Head Development Regulation Of Signal Transduction Anatomical Structure Development
Tagcloud ?			abundance acetylation attempt capability cognate consolidate coordinating cytoplasmic deacetylase deacetylation diversity dnaj dnaja1 elucidated hdac6 homolog hsc70 knockout modulates monitor myosin negatively notion participates predominantly proteomic serves subfamily verified
Tagcloud (Difference) ?			abundance acetylation attempt capability cognate consolidate coordinating cytoplasmic deacetylase deacetylation diversity dnaj dnaja1 elucidated hdac6 homolog hsc70 knockout modulates monitor myosin negatively notion participates predominantly proteomic serves subfamily verified
Tagcloud (Intersection) ?