MYH9 and CD163

Number of citations of the paper that reports this interaction (PMID 15479433)
1

Data Source:
HPRD (in vivo)

		MYH9	CD163
Gene Name		myosin, heavy chain 9, non-muscle	CD163 molecule
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Stress Fiber Ruffle Immunological Synapse Uropod Nucleus Cytoplasm Spindle Actomyosin Contractile Ring Cytosol Plasma Membrane Cell-cell Adherens Junction COP9 Signalosome Integrin Complex Actin Cytoskeleton Membrane Myosin II Complex Cortical Cytoskeleton Cell Leading Edge Neuromuscular Junction Cleavage Furrow Actomyosin Protein Complex Extracellular Vesicular Exosome Myosin II Filament	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Endocytic Vesicle Membrane
	Molecular Function	Microfilament Motor Activity Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding ATPase Activity Actin-dependent ATPase Activity Protein Homodimerization Activity Protein Anchor ADP Binding Poly(A) RNA Binding Actin Filament Binding	Scavenger Receptor Activity Protein Binding
	Biological Process	Meiotic Spindle Organization Cytokinesis Angiogenesis In Utero Embryonic Development Establishment Of T Cell Polarity Membrane Protein Ectodomain Proteolysis Integrin-mediated Signaling Pathway Axon Guidance Myoblast Fusion Regulation Of Cell Shape Protein Transport Actin Filament-based Movement Platelet Formation Monocyte Differentiation Actomyosin Structure Organization Actin Cytoskeleton Reorganization Uropod Organization Termination Of G-protein Coupled Receptor Signaling Pathway Blood Vessel Endothelial Cell Migration Ephrin Receptor Signaling Pathway Leukocyte Migration Establishment Of Meiotic Spindle Localization Platelet Aggregation	Receptor-mediated Endocytosis Acute-phase Response
Pathways		EPHA-mediated growth cone collapse Axon guidance Semaphorin interactions EPH-Ephrin signaling Sema4D in semaphorin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Sema4D induced cell migration and growth-cone collapse Innate Immune System	Scavenging of heme from plasma
Drugs
Diseases
GWAS		End-stage renal disease (non-diabetic) ( 20532800) Glomerulosclerosis ( 20668430) Optic disc size (rim) ( 20395239)	Hematological and biochemical traits ( 20139978)
Protein-Protein Interactions		22 interactors: ASCC2 CASP4 CBL CD163 CSNK2A1 CXCR4 GRB2 GRIN1 MEN1 MYBPC3 MYH10 MYL9 MYOM1 MYOM2 OVGP1 PPP2CA PTPN6 RAC1 S100A4 TTN TUFM YWHAZ	4 interactors: CSNK2B HP MYH9 PRKCA
Entrez ID		4627	9332
HPRD ID		01177	05708
Ensembl ID		ENSG00000100345	ENSG00000177575
Uniprot IDs		P35579	C9JHR8 Q86VB7
PDB IDs		2LNK 3ZWH 4ETO
Enriched GO Terms of Interacting Partners?		Cell Morphogenesis Involved In Differentiation Cell Development Platelet Activation Axon Guidance Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Morphogenesis Movement Of Cell Or Subcellular Component Anatomical Structure Morphogenesis Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Wound Healing Chemotaxis Locomotion Positive Regulation Of Signal Transduction Neuron Projection Morphogenesis Apoptotic Process Muscle Contraction Cell Activation Blood Coagulation Programmed Cell Death Hemostasis Ephrin Receptor Signaling Pathway Response To Wounding Cell Death Death Muscle System Process Neuron Projection Development Cell Projection Morphogenesis Myosin Filament Assembly Cell Part Morphogenesis Regulation Of Body Fluid Levels Cell Differentiation Neuron Development Regulation Of Cellular Component Organization Actin Filament-based Movement Regulation Of Signaling Cell Surface Receptor Signaling Pathway Endomembrane System Organization Neuron Differentiation T Cell Costimulation Myofibril Assembly Leukocyte Migration Brain Development Cell Projection Organization Regulation Of Kinase Activity Head Development Regulation Of Signal Transduction Anatomical Structure Development	Regulation Of Blood Vessel Endothelial Cell Migration Response To External Stimulus Chemotaxis Regulation Of Endothelial Cell Migration Negative Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of Dense Core Granule Biogenesis Regulation Of Epithelial Cell Migration Histone H3-T6 Phosphorylation Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Platelet Activation Leukocyte Migration Locomotion Negative Regulation Of Hydrogen Peroxide Metabolic Process Cell Cycle Uropod Organization Establishment Of Meiotic Spindle Localization Establishment Of T Cell Polarity Movement Of Cell Or Subcellular Component Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Angiogenesis Positive Regulation Of Activin Receptor Signaling Pathway Adiponectin-activated Signaling Pathway Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Axon Guidance Regulation Of Hydrogen Peroxide Metabolic Process Endothelial Tube Morphogenesis Negative Regulation Of Glucose Import Blood Coagulation Blood Vessel Morphogenesis Hemostasis Positive Regulation Of Macrophage Differentiation Meiotic Spindle Organization Desmosome Organization Blood Vessel Development Regulation Of Platelet Aggregation Negative Regulation Of Glucose Transport Immune System Process Axonogenesis Induction Of Positive Chemotaxis Positive Regulation Of Cardiac Muscle Hypertrophy Vasculature Development Protein Metabolic Process Monocyte Differentiation Membrane Protein Ectodomain Proteolysis Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Lipopolysaccharide-mediated Signaling Pathway Axon Development
Tagcloud ?		abundance acetylation attempt capability cognate consolidate coordinating cytoplasmic deacetylase deacetylation diversity dnaj dnaja1 elucidated hdac6 homolog hsc70 knockout modulates monitor myosin negatively notion participates predominantly proteomic serves subfamily verified	27cm3 39cm3 alternatively capacities ccl22 considering correlate cultivation documented emt hazard hcc hepatocellular infiltration injuries invasiveness m2 macrophage macrophages mesenchymal mhcc97l nodules orthotopic proven quantified scavenger snail tumour venous
Tagcloud (Difference) ?		abundance acetylation attempt capability cognate consolidate coordinating cytoplasmic deacetylase deacetylation diversity dnaj dnaja1 elucidated hdac6 homolog hsc70 knockout modulates monitor myosin negatively notion participates predominantly proteomic serves subfamily verified	27cm3 39cm3 alternatively capacities ccl22 considering correlate cultivation documented emt hazard hcc hepatocellular infiltration injuries invasiveness m2 macrophage macrophages mesenchymal mhcc97l nodules orthotopic proven quantified scavenger snail tumour venous
Tagcloud (Intersection) ?