MYH9 and CXCR4

Number of citations of the paper that reports this interaction (PMID 12421915)
10

Data Source:
HPRD (in vitro)

		MYH9	CXCR4
Gene Name		myosin, heavy chain 9, non-muscle	chemokine (C-X-C motif) receptor 4
Image
Gene Ontology Annotations	Cellular Component	Stress Fiber Ruffle Immunological Synapse Uropod Nucleus Cytoplasm Spindle Actomyosin Contractile Ring Cytosol Plasma Membrane Cell-cell Adherens Junction COP9 Signalosome Integrin Complex Actin Cytoskeleton Membrane Myosin II Complex Cortical Cytoskeleton Cell Leading Edge Neuromuscular Junction Cleavage Furrow Actomyosin Protein Complex Extracellular Vesicular Exosome Myosin II Filament	Cytoplasm Lysosome Early Endosome Late Endosome Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Cytoplasmic Membrane-bounded Vesicle Growth Cone Cell Leading Edge Cytoplasmic Vesicle Extracellular Vesicular Exosome
	Molecular Function	Microfilament Motor Activity Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding ATPase Activity Actin-dependent ATPase Activity Protein Homodimerization Activity Protein Anchor ADP Binding Poly(A) RNA Binding Actin Filament Binding	Virus Receptor Activity Actin Binding G-protein Coupled Receptor Activity Protein Binding Coreceptor Activity C-X-C Chemokine Receptor Activity Cytokine Binding Ubiquitin Protein Ligase Binding Myosin Light Chain Binding Ubiquitin Binding
	Biological Process	Meiotic Spindle Organization Cytokinesis Angiogenesis In Utero Embryonic Development Establishment Of T Cell Polarity Membrane Protein Ectodomain Proteolysis Integrin-mediated Signaling Pathway Axon Guidance Myoblast Fusion Regulation Of Cell Shape Protein Transport Actin Filament-based Movement Platelet Formation Monocyte Differentiation Actomyosin Structure Organization Actin Cytoskeleton Reorganization Uropod Organization Termination Of G-protein Coupled Receptor Signaling Pathway Blood Vessel Endothelial Cell Migration Ephrin Receptor Signaling Pathway Leukocyte Migration Establishment Of Meiotic Spindle Localization Platelet Aggregation	Activation Of MAPK Activity Patterning Of Blood Vessels Response To Hypoxia Ameboidal-type Cell Migration Neuron Migration Dendritic Cell Chemotaxis Apoptotic Process Inflammatory Response G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Germ Cell Development Brain Development Motor Neuron Axon Guidance Germ Cell Migration Response To Virus Viral Process Calcium-mediated Signaling Entry Into Host Cell Regulation Of Cell Migration T Cell Proliferation Neutrophil Activation Myelin Maintenance Positive Regulation Of Oligodendrocyte Differentiation Regulation Of Chemotaxis Neural Precursor Cell Proliferation Chemokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus
Pathways		EPHA-mediated growth cone collapse Axon guidance Semaphorin interactions EPH-Ephrin signaling Sema4D in semaphorin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Sema4D induced cell migration and growth-cone collapse Innate Immune System	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR HIV Infection Class A/1 (Rhodopsin-like receptors) GPCR ligand binding Metabolic disorders of biological oxidation enzymes Early Phase of HIV Life Cycle GPCR downstream signaling HIV Life Cycle Peptide ligand-binding receptors Chemokine receptors bind chemokines G alpha (i) signalling events Binding and entry of HIV virion
Drugs			Framycetin Plerixafor
Diseases
GWAS		End-stage renal disease (non-diabetic) ( 20532800) Glomerulosclerosis ( 20668430) Optic disc size (rim) ( 20395239)	Multiple sclerosis ( 19525953) Telomere length ( 20421499)
Protein-Protein Interactions		22 interactors: ASCC2 CASP4 CBL CD163 CSNK2A1 CXCR4 GRB2 GRIN1 MEN1 MYBPC3 MYH10 MYL9 MYOM1 MYOM2 OVGP1 PPP2CA PTPN6 RAC1 S100A4 TTN TUFM YWHAZ	32 interactors: ADRBK2 ARRB2 ATP13A2 CCR5 CD4 CTSG CXCL12 DPP4 ELANE GNA13 GNAI1 HLA-C HSPA8 ITCH JAK1 JAK2 JAK3 MYBL2 MYH9 PTK2 PTPN11 PTPN6 PTPRC SDC4 SOCS1 SOCS3 STAT1 STAT2 STAT3 STAT5B USP14 VAV1
Entrez ID		4627	7852
HPRD ID		01177	01217
Ensembl ID		ENSG00000100345	ENSG00000121966
Uniprot IDs		P35579	P61073
PDB IDs		2LNK 3ZWH 4ETO	2K03 2K04 2K05 3ODU 3OE0 3OE6 3OE8 3OE9
Enriched GO Terms of Interacting Partners?		Cell Morphogenesis Involved In Differentiation Cell Development Platelet Activation Axon Guidance Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Morphogenesis Movement Of Cell Or Subcellular Component Anatomical Structure Morphogenesis Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Wound Healing Chemotaxis Locomotion Positive Regulation Of Signal Transduction Neuron Projection Morphogenesis Apoptotic Process Muscle Contraction Cell Activation Blood Coagulation Programmed Cell Death Hemostasis Ephrin Receptor Signaling Pathway Response To Wounding Cell Death Death Muscle System Process Neuron Projection Development Cell Projection Morphogenesis Myosin Filament Assembly Cell Part Morphogenesis Regulation Of Body Fluid Levels Cell Differentiation Neuron Development Regulation Of Cellular Component Organization Actin Filament-based Movement Regulation Of Signaling Cell Surface Receptor Signaling Pathway Endomembrane System Organization Neuron Differentiation T Cell Costimulation Myofibril Assembly Leukocyte Migration Brain Development Cell Projection Organization Regulation Of Kinase Activity Head Development Regulation Of Signal Transduction Anatomical Structure Development	Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Regulation Of Immune Response Regulation Of Immune System Process Response To Growth Hormone JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Response To Stress Defense Response JAK-STAT Cascade Cytokine-mediated Signaling Pathway Immune System Process Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Immune Response Regulation Of Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Regulation Of Innate Immune Response Regulation Of Cell-cell Adhesion Locomotion Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Cytokine Regulation Of Type I Interferon-mediated Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Response To Organic Substance Response To Peptide Hormone Regulation Of Cell Adhesion Innate Immune Response Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Peptide Signaling Movement Of Cell Or Subcellular Component Response To Type I Interferon Cell Migration Positive Regulation Of Cell Adhesion Cell Communication Response To External Stimulus Cell Activation Positive Regulation Of Immune System Process Interferon-gamma-mediated Signaling Pathway Cell Motility Response To Stimulus Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Cellular Response To Interferon-gamma Regulation Of Signal Transduction Signal Transduction Cellular Response To Organic Substance Response To Interferon-gamma
Tagcloud ?		abundance acetylation attempt capability cognate consolidate coordinating cytoplasmic deacetylase deacetylation diversity dnaj dnaja1 elucidated hdac6 homolog hsc70 knockout modulates monitor myosin negatively notion participates predominantly proteomic serves subfamily verified	capture ccr1 ccr2 ccr5 ccr7 cd40 chemokine chemokines cxcr1 dc dendritic ebi1 elc immature inflamed insight lost lymphoid marginally maturation mature maturing migrate nodes organs phases respective responded responsiveness
Tagcloud (Difference) ?		abundance acetylation attempt capability cognate consolidate coordinating cytoplasmic deacetylase deacetylation diversity dnaj dnaja1 elucidated hdac6 homolog hsc70 knockout modulates monitor myosin negatively notion participates predominantly proteomic serves subfamily verified	capture ccr1 ccr2 ccr5 ccr7 cd40 chemokine chemokines cxcr1 dc dendritic ebi1 elc immature inflamed insight lost lymphoid marginally maturation mature maturing migrate nodes organs phases respective responded responsiveness
Tagcloud (Intersection) ?