GRIN1 and EPHB4

Number of citations of the paper that reports this interaction (PMID 11136979)
148

Data Source:
HPRD (in vivo)

		GRIN1	EPHB4
Gene Name		glutamate receptor, ionotropic, N-methyl D-aspartate 1	EPH receptor B4
Image
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle Cell Surface Postsynaptic Density N-methyl-D-aspartate Selective Glutamate Receptor Complex Cell Junction Dendrite Dendrite Membrane Neuron Projection Synaptic Cleft Terminal Bouton Dendritic Spine Synapse Postsynaptic Membrane Excitatory Synapse Neuronal Postsynaptic Density	Extracellular Region Cytosol Plasma Membrane Integral Component Of Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	N-methyl-D-aspartate Selective Glutamate Receptor Activity Extracellular-glutamate-gated Ion Channel Activity Calcium Channel Activity Calcium Ion Binding Protein Binding Calmodulin Binding Glycine Binding Glutamate Binding Enzyme Binding Voltage-gated Cation Channel Activity Glutamate Receptor Binding Neurotransmitter Binding Protein Heterodimerization Activity	Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity Protein Binding ATP Binding
	Biological Process	Conditioned Taste Aversion Suckling Behavior Response To Amphetamine Cation Transport Cellular Calcium Ion Homeostasis Synaptic Transmission Axon Guidance Respiratory Gaseous Exchange Long-term Memory Adult Locomotory Behavior Olfactory Learning Visual Learning Propylene Metabolic Process Sensory Perception Of Pain Pons Maturation Cerebral Cortex Development Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Social Behavior Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Membrane Potential Positive Regulation Of Apoptotic Process Response To Morphine Negative Regulation Of Neuron Apoptotic Process Regulation Of Respiratory Gaseous Exchange Response To Ethanol Positive Regulation Of Transcription From RNA Polymerase II Promoter Ephrin Receptor Signaling Pathway Regulation Of Long-term Neuronal Synaptic Plasticity Rhythmic Process Regulation Of Dendrite Morphogenesis Regulation Of Axonogenesis Protein Tetramerization Response To Calcium Ion Regulation Of Synapse Assembly Calcium Ion Homeostasis Regulation Of Excitatory Postsynaptic Membrane Potential Prepulse Inhibition Male Mating Behavior Response To Fungicide Calcium Ion Transmembrane Transport Cellular Response To Manganese Ion Positive Regulation Of Excitatory Postsynaptic Membrane Potential	Angiogenesis Cell Migration Involved In Sprouting Angiogenesis Heart Morphogenesis Cell Adhesion Axon Guidance Peptidyl-tyrosine Phosphorylation Protein Autophosphorylation Ephrin Receptor Signaling Pathway
Pathways		EPHB-mediated forward signaling Axon guidance Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII EPH-Ephrin signaling CREB phosphorylation through the activation of Ras Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Unblocking of NMDA receptor, glutamate binding and activation Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses	EPHB-mediated forward signaling Ephrin signaling EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling
Drugs		L-Glutamic Acid Meperidine Orphenadrine Dcka, 5,7-Dichlorokynurenic Acid D-Serine Cycloleucine Milnacipran Agmatine
Diseases
GWAS		Post-traumatic stress disorder (asjusted for relatedness) ( 23726511)	Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020)
Protein-Protein Interactions		53 interactors: ACTN2 AKAP9 CALM1 CAMK2A CAMK2G CANX CDH2 CIT CLTC CTNNB1 DLG2 DLG3 DLG4 DLGAP4 DNM1 DRD1 DUSP4 EPHB2 EPHB4 FUS FYN GRIN2A GRIN2B GRIN2D GRIN3A HNRNPU HRAS HSPA1A INA LNX1 LRP8 MAP2 MAP2K2 MYH9 NANOS1 NEFL NF1 PLAT PLCG1 PPP2R1A PPP2R2A PRKCA PRKCB PRKCE PRKCG RAP2A RPS6KA3 SP3 SPTAN1 SYNGAP1 TJP1 TRAF3 TUBA4B	4 interactors: APP EFNB2 GRIN1 SDC3
Entrez ID		2902	2050
HPRD ID		15926	02481
Ensembl ID		ENSG00000176884	ENSG00000196411
Uniprot IDs		Q05586 Q59GW0 Q5VSF9	P54760 Q541P7 Q7Z635 Q96L35
PDB IDs		2HQW 2NR1 3BYA	2BBA 2E7H 2HLE 2QKQ 2VWU 2VWV 2VWW 2VWX 2VWY 2VWZ 2VX0 2VX1 2X9F 2XVD 4AW5 4BB4
Enriched GO Terms of Interacting Partners?		Synaptic Transmission Cell-cell Signaling Nervous System Development Signaling Locomotion Cell Communication Neurogenesis Cell Differentiation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Organic Substance Generation Of Neurons Neuron Projection Development Neuron Development Developmental Process Cell Development Neuron Differentiation Response To External Stimulus Signal Transduction Cell Projection Organization Movement Of Cell Or Subcellular Component Enzyme Linked Receptor Protein Signaling Pathway Multicellular Organismal Development System Development Cellular Response To Stimulus Anatomical Structure Development Axon Development Axon Guidance Regulation Of Synaptic Transmission Regulation Of Synaptic Plasticity Neuron Projection Morphogenesis Cell Surface Receptor Signaling Pathway Axonogenesis Cellular Response To Organic Substance Response To Wounding Cell Morphogenesis Involved In Neuron Differentiation Cell Morphogenesis Involved In Differentiation Learning Response To Stimulus Regulation Of Signaling Chemotaxis Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Response To Abiotic Stimulus Fibroblast Growth Factor Receptor Signaling Pathway Blood Coagulation Hemostasis Cell Projection Morphogenesis Single-organism Behavior Cellular Response To Growth Factor Stimulus Learning Or Memory	Suckling Behavior Response To Light Stimulus Mating Behavior Axon Guidance Ionotropic Glutamate Receptor Signaling Pathway Response To Radiation Mating Response To External Stimulus Glutamate Receptor Signaling Pathway Visual Learning Axonogenesis Visual Behavior Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Associative Learning Neuron Projection Morphogenesis Regulation Of Synapse Structure Or Activity Ephrin Receptor Signaling Pathway Feeding Behavior Cell Morphogenesis Involved In Differentiation Adult Locomotory Behavior Neuron Projection Development Propylene Metabolic Process Cell Projection Morphogenesis Neuromuscular Process Cell Part Morphogenesis Learning Neuron Development Adult Behavior Synaptic Growth At Neuromuscular Junction Olfactory Learning Cell Morphogenesis Response To Abiotic Stimulus Neuron Differentiation Cell Projection Organization Collateral Sprouting In Absence Of Injury Pons Maturation Locomotory Behavior Locomotion Learning Or Memory Collateral Sprouting Axon Midline Choice Point Recognition Cellular Response To Manganese Ion Cognition Cellular Calcium Ion Homeostasis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Movement Of Cell Or Subcellular Component Calcium Ion Homeostasis Axon Choice Point Recognition
Tagcloud ?			advantages autophosphorylation barely bhg712 explained fibroblasts fibrosarcoma heterogeneous intraperitoneal liposarcoma malignancies malignancy mesenchymal metastases mfh nvp residual sarcoma sarcomas soft spots sts summary synovial transmigration tumorigenesis vimentin vitality xenograft
Tagcloud (Difference) ?			advantages autophosphorylation barely bhg712 explained fibroblasts fibrosarcoma heterogeneous intraperitoneal liposarcoma malignancies malignancy mesenchymal metastases mfh nvp residual sarcoma sarcomas soft spots sts summary synovial transmigration tumorigenesis vimentin vitality xenograft
Tagcloud (Intersection) ?