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GRIN1 and PPP2R1A
Number of citations of the paper that reports this interaction (PMID
10862698
)
203
Data Source:
HPRD
(in vivo)
GRIN1
PPP2R1A
Gene Name
glutamate receptor, ionotropic, N-methyl D-aspartate 1
protein phosphatase 2, regulatory subunit A, alpha
Image
Gene Ontology Annotations
Cellular Component
Endoplasmic Reticulum
Plasma Membrane
Integral Component Of Plasma Membrane
Synaptic Vesicle
Cell Surface
Postsynaptic Density
N-methyl-D-aspartate Selective Glutamate Receptor Complex
Cell Junction
Dendrite
Dendrite Membrane
Neuron Projection
Synaptic Cleft
Terminal Bouton
Dendritic Spine
Synapse
Postsynaptic Membrane
Excitatory Synapse
Neuronal Postsynaptic Density
Protein Phosphatase Type 2A Complex
Chromosome, Centromeric Region
Nucleus
Mitochondrion
Cytosol
Microtubule Cytoskeleton
Membrane
Extracellular Vesicular Exosome
Molecular Function
N-methyl-D-aspartate Selective Glutamate Receptor Activity
Extracellular-glutamate-gated Ion Channel Activity
Calcium Channel Activity
Calcium Ion Binding
Protein Binding
Calmodulin Binding
Glycine Binding
Glutamate Binding
Enzyme Binding
Voltage-gated Cation Channel Activity
Glutamate Receptor Binding
Neurotransmitter Binding
Protein Heterodimerization Activity
Antigen Binding
Protein Serine/threonine Phosphatase Activity
Protein Binding
Protein Phosphatase Type 2A Regulator Activity
Protein Heterodimerization Activity
Biological Process
Conditioned Taste Aversion
Suckling Behavior
Response To Amphetamine
Cation Transport
Cellular Calcium Ion Homeostasis
Synaptic Transmission
Axon Guidance
Respiratory Gaseous Exchange
Long-term Memory
Adult Locomotory Behavior
Olfactory Learning
Visual Learning
Propylene Metabolic Process
Sensory Perception Of Pain
Pons Maturation
Cerebral Cortex Development
Ion Transmembrane Transport
Regulation Of Ion Transmembrane Transport
Social Behavior
Ionotropic Glutamate Receptor Signaling Pathway
Synaptic Transmission, Glutamatergic
Regulation Of Membrane Potential
Positive Regulation Of Apoptotic Process
Response To Morphine
Negative Regulation Of Neuron Apoptotic Process
Regulation Of Respiratory Gaseous Exchange
Response To Ethanol
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Ephrin Receptor Signaling Pathway
Regulation Of Long-term Neuronal Synaptic Plasticity
Rhythmic Process
Regulation Of Dendrite Morphogenesis
Regulation Of Axonogenesis
Protein Tetramerization
Response To Calcium Ion
Regulation Of Synapse Assembly
Calcium Ion Homeostasis
Regulation Of Excitatory Postsynaptic Membrane Potential
Prepulse Inhibition
Male Mating Behavior
Response To Fungicide
Calcium Ion Transmembrane Transport
Cellular Response To Manganese Ion
Positive Regulation Of Excitatory Postsynaptic Membrane Potential
G2/M Transition Of Mitotic Cell Cycle
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Inactivation Of MAPK Activity
Mitotic Cell Cycle
Regulation Of DNA Replication
Regulation Of Transcription, DNA-templated
Protein Complex Assembly
Protein Dephosphorylation
Ceramide Metabolic Process
Apoptotic Process
Organelle Organization
Chromosome Segregation
Mitotic Nuclear Envelope Reassembly
RNA Splicing
Fibroblast Growth Factor Receptor Signaling Pathway
Response To Organic Substance
Gene Expression
Second-messenger-mediated Signaling
Regulation Of Wnt Signaling Pathway
Regulation Of Cell Adhesion
Negative Regulation Of Cell Growth
Regulation Of Growth
Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein
Regulation Of Cell Differentiation
Peptidyl-serine Dephosphorylation
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
EPHB-mediated forward signaling
Axon guidance
Activation of NMDA receptor upon glutamate binding and postsynaptic events
CREB phosphorylation through the activation of CaMKII
EPH-Ephrin signaling
CREB phosphorylation through the activation of Ras
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Unblocking of NMDA receptor, glutamate binding and activation
Ras activation uopn Ca2+ infux through NMDA receptor
Post NMDA receptor activation events
Transmission across Chemical Synapses
Signaling by FGFR in disease
Integration of energy metabolism
misspliced GSK3beta mutants stabilize beta-catenin
T41 mutants of beta-catenin aren't phosphorylated
ERKs are inactivated
Toll Like Receptor TLR1:TLR2 Cascade
Glucose metabolism
Degradation of beta-catenin by the destruction complex
Toll Like Receptor 5 (TLR5) Cascade
AXIN mutants destabilize the destruction complex, activating WNT signaling
S33 mutants of beta-catenin aren't phosphorylated
MyD88 dependent cascade initiated on endosome
Glycogen storage diseases
Beta-catenin phosphorylation cascade
Mitotic G1-G1/S phases
Recruitment of mitotic centrosome proteins and complexes
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
TRIF-mediated TLR3/TLR4 signaling
S45 mutants of beta-catenin aren't phosphorylated
Spry regulation of FGF signaling
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
deletions in the AMER1 gene destabilize the destruction complex
AMER1 mutants destabilize the destruction complex
Platelet sensitization by LDL
Resolution of Sister Chromatid Cohesion
Toll Like Receptor 3 (TLR3) Cascade
Metabolism of carbohydrates
Mitotic G2-G2/M phases
Adaptive Immune System
MASTL Facilitates Mitotic Progression
Separation of Sister Chromatids
APC truncation mutants have impaired AXIN binding
G2/M Transition
disassembly of the destruction complex and recruitment of AXIN to the membrane
Activated TLR4 signalling
S37 mutants of beta-catenin aren't phosphorylated
Cyclin A/B1 associated events during G2/M transition
Loss of Nlp from mitotic centrosomes
XAV939 inhibits tankyrase, stabilizing AXIN
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88:Mal cascade initiated on plasma membrane
Innate Immune System
Nonsense-Mediated Decay (NMD)
E2F mediated regulation of DNA replication
ERKs are inactivated
G1 Phase
CTLA4 inhibitory signaling
Signaling by FGFR
Cyclin D associated events in G1
Toll-Like Receptors Cascades
Toll Like Receptor 10 (TLR10) Cascade
TCF dependent signaling in response to WNT
ERK/MAPK targets
MAPK targets/ Nuclear events mediated by MAP kinases
Signaling by WNT in cancer
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Signaling by GPCR
Mitotic Prophase
TCF7L2 mutants don't bind CTBP
truncated APC mutants destabilize the destruction complex
Signaling by Wnt
Glycolysis
Regulation of PLK1 Activity at G2/M Transition
RNF mutants show enhanced WNT signaling and proliferation
G1/S Transition
Myoclonic epilepsy of Lafora
Toll Like Receptor 9 (TLR9) Cascade
Initiation of Nuclear Envelope Reformation
ERK/MAPK targets
truncations of AMER1 destabilize the destruction complex
Negative regulation of FGFR signaling
Opioid Signalling
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
AXIN missense mutants destabilize the destruction complex
Toll Like Receptor 2 (TLR2) Cascade
Platelet homeostasis
Toll Like Receptor 4 (TLR4) Cascade
Mitotic Metaphase and Anaphase
PP2A-mediated dephosphorylation of key metabolic factors
Mitotic Prometaphase
Organelle biogenesis and maintenance
Costimulation by the CD28 family
Toll Like Receptor 7/8 (TLR7/8) Cascade
Mitotic Anaphase
APC truncation mutants are not K63 polyubiquitinated
M Phase
Toll Like Receptor TLR6:TLR2 Cascade
MyD88 cascade initiated on plasma membrane
DARPP-32 events
Nuclear Envelope Reassembly
Signalling by NGF
MAP kinase activation in TLR cascade
Assembly of the primary cilium
NGF signalling via TRKA from the plasma membrane
MyD88-independent cascade
Anchoring of the basal body to the plasma membrane
Cell Cycle, Mitotic
Loss of proteins required for interphase microtubule organization from the centrosome
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
Centrosome maturation
Nuclear Events (kinase and transcription factor activation)
Drugs
L-Glutamic Acid
Meperidine
Orphenadrine
Dcka, 5,7-Dichlorokynurenic Acid
D-Serine
Cycloleucine
Milnacipran
Agmatine
Diseases
GWAS
Post-traumatic stress disorder (asjusted for relatedness) (
23726511
)
Protein-Protein Interactions
53 interactors:
ACTN2
AKAP9
CALM1
CAMK2A
CAMK2G
CANX
CDH2
CIT
CLTC
CTNNB1
DLG2
DLG3
DLG4
DLGAP4
DNM1
DRD1
DUSP4
EPHB2
EPHB4
FUS
FYN
GRIN2A
GRIN2B
GRIN2D
GRIN3A
HNRNPU
HRAS
HSPA1A
INA
LNX1
LRP8
MAP2
MAP2K2
MYH9
NANOS1
NEFL
NF1
PLAT
PLCG1
PPP2R1A
PPP2R2A
PRKCA
PRKCB
PRKCE
PRKCG
RAP2A
RPS6KA3
SP3
SPTAN1
SYNGAP1
TJP1
TRAF3
TUBA4B
39 interactors:
AIMP2
AKT1
ARIH2
CDK1
CSDC2
EEF2
GNA12
GRIN1
GRIN2D
HSF2
HSPD1
IPO9
MAP3K7
MAPK6
MCM3
PARK7
PLA2G16
PPP2CA
PPP2R2A
PPP2R3B
PPP2R5A
PPP4C
PPP5C
PRDX1
PRDX2
RAB11A
RAB18
RAB7A
RAP1A
SGOL1
SGOL2
SLC6A2
SMAD2
SMAD3
STRN
STRN3
TAB1
TRADD
ZFYVE9
Entrez ID
2902
5518
HPRD ID
15926
16184
Ensembl ID
ENSG00000176884
Uniprot IDs
Q05586
Q59GW0
Q5VSF9
A8K7B7
P30153
PDB IDs
2HQW
2NR1
3BYA
1B3U
2IE3
2IE4
2NPP
2NYL
2NYM
2PKG
3C5W
3DW8
3K7V
3K7W
4I5L
4I5N
Enriched GO Terms of Interacting Partners
?
Synaptic Transmission
Cell-cell Signaling
Nervous System Development
Signaling
Locomotion
Cell Communication
Neurogenesis
Cell Differentiation
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Response To Organic Substance
Generation Of Neurons
Neuron Projection Development
Neuron Development
Developmental Process
Cell Development
Neuron Differentiation
Response To External Stimulus
Signal Transduction
Cell Projection Organization
Movement Of Cell Or Subcellular Component
Enzyme Linked Receptor Protein Signaling Pathway
Multicellular Organismal Development
System Development
Cellular Response To Stimulus
Anatomical Structure Development
Axon Development
Axon Guidance
Regulation Of Synaptic Transmission
Regulation Of Synaptic Plasticity
Neuron Projection Morphogenesis
Cell Surface Receptor Signaling Pathway
Axonogenesis
Cellular Response To Organic Substance
Response To Wounding
Cell Morphogenesis Involved In Neuron Differentiation
Cell Morphogenesis Involved In Differentiation
Learning
Response To Stimulus
Regulation Of Signaling
Chemotaxis
Neurotrophin TRK Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Response To Abiotic Stimulus
Fibroblast Growth Factor Receptor Signaling Pathway
Blood Coagulation
Hemostasis
Cell Projection Morphogenesis
Single-organism Behavior
Cellular Response To Growth Factor Stimulus
Learning Or Memory
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Protein Metabolic Process
Ras Protein Signal Transduction
Signaling
Intracellular Signal Transduction
Signal Transduction
Cell Communication
Positive Regulation Of Cellular Metabolic Process
SMAD Protein Complex Assembly
Mitotic Cell Cycle
Cellular Response To Growth Factor Stimulus
Response To Growth Factor
Regulation Of Signaling
Cellular Response To Stimulus
Cell Cycle Process
Response To Organic Substance
Cell Cycle
Mitotic Cell Cycle Process
Enzyme Linked Receptor Protein Signaling Pathway
Regulation Of Cellular Protein Metabolic Process
Response To Stimulus
Regulation Of Signal Transduction
Transforming Growth Factor Beta Receptor Signaling Pathway
Protein Complex Assembly
Regulation Of Protein Metabolic Process
MyD88-dependent Toll-like Receptor Signaling Pathway
Regulation Of Cellular Process
Positive Regulation Of Metabolic Process
Response To Organic Cyclic Compound
Positive Regulation Of Protein Kinase Activity
Cellular Response To Transforming Growth Factor Beta Stimulus
Regulation Of Establishment Of Protein Localization
Positive Regulation Of Protein Modification Process
Response To Transforming Growth Factor Beta
Positive Regulation Of Kinase Activity
Negative Regulation Of Signaling
Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Apoptotic Process
Regulation Of Cysteine-type Endopeptidase Activity
Positive Regulation Of Signal Transduction
Cellular Response To Reactive Oxygen Species
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Hydrogen Peroxide Metabolic Process
Programmed Cell Death
Cellular Component Assembly
Positive Regulation Of Transferase Activity
Regulation Of Phosphorylation
Regulation Of Kinase Activity
Regulation Of Protein Localization
Toll-like Receptor Signaling Pathway
Tagcloud
?
arid1a
carcinomas
ccc
concurrent
constitute
ctnnb1
endometrial
endometrioid
endometrium
hepatocyte
hnf1beta
immunophenotype
mismatch
morphologically
mutated
napsin
oestrogen
oncogenesis
pole
predominance
prototypical
pten
pure
rigorously
serous
tp53
tumours
twelve
underscore
Tagcloud (Difference)
?
arid1a
carcinomas
ccc
concurrent
constitute
ctnnb1
endometrial
endometrioid
endometrium
hepatocyte
hnf1beta
immunophenotype
mismatch
morphologically
mutated
napsin
oestrogen
oncogenesis
pole
predominance
prototypical
pten
pure
rigorously
serous
tp53
tumours
twelve
underscore
Tagcloud (Intersection)
?