GRIN1 and NF1

Number of citations of the paper that reports this interaction (PubMedID 10862698)
0

Data Source:
HPRD (in vivo)

		GRIN1	NF1
Description		glutamate ionotropic receptor NMDA type subunit 1	neurofibromin 1
Image
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Plasma Membrane Synaptic Vesicle Cell Surface Postsynaptic Density Membrane NMDA Selective Glutamate Receptor Complex Dendrite Monoatomic Ion Channel Complex Neuron Projection Synaptic Cleft Terminal Bouton Dendritic Spine Synapse Postsynaptic Membrane Excitatory Synapse Synaptic Membrane Postsynaptic Density Membrane Neurotransmitter Receptor Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Membrane Axon Dendrite Presynapse Glutamatergic Synapse
	Molecular Function	Amyloid-beta Binding NMDA Glutamate Receptor Activity Monoatomic Ion Channel Activity Calcium Channel Activity Calcium Ion Binding Protein Binding Calmodulin Binding Ligand-gated Monoatomic Ion Channel Activity Ligand-gated Sodium Channel Activity Glycine Binding Glutamate Binding Glutamate-gated Calcium Ion Channel Activity Signaling Receptor Activity Protein-containing Complex Binding Metal Ion Binding Glycine-gated Cation Channel Activity	GTPase Activator Activity Protein Binding Lipid Binding Phosphatidylethanolamine Binding Phosphatidylcholine Binding
	Biological Process	Monoatomic Ion Transport Monoatomic Cation Transport Chemical Synaptic Transmission Brain Development Visual Learning Positive Regulation Of Calcium Ion Transport Into Cytosol Propylene Metabolic Process Calcium-mediated Signaling Monoatomic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Sodium Ion Transmembrane Transport Regulation Of Membrane Potential Response To Ethanol Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Protein Heterotetramerization Positive Regulation Of Synaptic Transmission, Glutamatergic Calcium Ion Homeostasis Excitatory Postsynaptic Potential Calcium Ion Transmembrane Transport Calcium Ion Transmembrane Import Into Cytosol Monoatomic Cation Transmembrane Transport Excitatory Chemical Synaptic Transmission Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Monoatomic Cation Transmembrane Transport Cellular Response To Amyloid-beta Response To Glycine Positive Regulation Of Excitatory Postsynaptic Potential	MAPK Cascade Angiogenesis Osteoblast Differentiation Metanephros Development Response To Hypoxia Liver Development Endothelial Cell Proliferation Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Regulation Of Cell-matrix Adhesion Negative Regulation Of Cell-matrix Adhesion Negative Regulation Of Leukocyte Migration Protein Import Into Nucleus Apoptotic Process Cell Communication Ras Protein Signal Transduction Neurotransmitter Secretion Neuroblast Proliferation Negative Regulation Of Neuroblast Proliferation Brain Development Peripheral Nervous System Development Heart Development Skeletal Muscle Tissue Development Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Visual Learning Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Gene Expression Negative Regulation Of Schwann Cell Proliferation Glial Cell Proliferation Schwann Cell Proliferation Schwann Cell Development Cell Migration Negative Regulation Of Angiogenesis Rac Protein Signal Transduction Spinal Cord Development Amygdala Development Forebrain Astrocyte Development Neural Tube Development Cerebral Cortex Development Myelination In Peripheral Nervous System Actin Cytoskeleton Organization Extracellular Matrix Organization Collagen Fibril Organization Osteoclast Differentiation Adrenal Gland Development Negative Regulation Of Cell Migration Regulation Of Synaptic Transmission, GABAergic Mast Cell Apoptotic Process Positive Regulation Of Mast Cell Apoptotic Process Myeloid Cell Apoptotic Process Positive Regulation Of Myeloid Cell Apoptotic Process Cellular Response To Heat Negative Regulation Of Rac Protein Signal Transduction Schwann Cell Migration Wound Healing Regulation Of Cell Population Proliferation Negative Regulation Of Protein Import Into Nucleus Positive Regulation Of Apoptotic Process Regulation Of MAPK Cascade Negative Regulation Of MAPK Cascade Pigmentation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Neuron Apoptotic Process Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of GTPase Activity Regulation Of Bone Resorption Negative Regulation Of Osteoclast Differentiation Regulation Of Glial Cell Differentiation Regulation Of Angiogenesis Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Neurotransmitter Secretion Fibroblast Proliferation Negative Regulation Of Fibroblast Proliferation Regulation Of Long-term Neuronal Synaptic Plasticity Sympathetic Nervous System Development Camera-type Eye Morphogenesis Astrocyte Differentiation Oligodendrocyte Differentiation Negative Regulation Of Astrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation Smooth Muscle Tissue Development Hair Follicle Maturation Artery Morphogenesis Forebrain Morphogenesis Regulation Of Developmental Process Cognition Neuron Apoptotic Process Negative Regulation Of Glial Cell Proliferation Long-term Synaptic Potentiation Gamma-aminobutyric Acid Secretion, Neurotransmission Glutamate Secretion, Neurotransmission Regulation Of ERK1 And ERK2 Cascade Mast Cell Proliferation Negative Regulation Of Mast Cell Proliferation Leukocyte Apoptotic Process Stem Cell Proliferation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Myeloid Leukocyte Migration Observational Learning Regulation Of Postsynapse Organization Negative Regulation Of Schwann Cell Migration Regulation Of Long-term Synaptic Potentiation Regulation Of Intracellular Signal Transduction Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Vascular Associated Smooth Muscle Cell Migration Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Leukocyte Apoptotic Process Negative Regulation Of Stem Cell Proliferation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		EPHB-mediated forward signaling EPHB-mediated forward signaling Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation	Regulation of RAS by GAPs RAS signaling downstream of NF1 loss-of-function variants
Drugs		Glutamic acid Tramadol Enflurane Atomoxetine Pentobarbital Methadone Secobarbital Meperidine Dextropropoxyphene Acamprosate Donepezil Guaifenesin Memantine Memantine Orphenadrine Phenobarbital Aripiprazole Prasterone 5,7-Dichlorokynurenic acid D-Serine Cycloleucine Milnacipran CNS-5161 Acetylcysteine Ketobemidone Gavestinel Agmatine Ifenprodil Magnesium acetate tetrahydrate Magnesium carbonate Esketamine Fluciclovine (18F)
Diseases			Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS		Post-traumatic stress disorder (asjusted for relatedness) ( 23726511)	Adventurousness ( 30643258) Apolipoprotein B levels ( 32203549) Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 33547301) Bitter alcoholic beverage consumption ( 31046077) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Familial squamous cell lung carcinoma ( 29924316) Feeling nervous ( 29500382) General risk tolerance (MTAG) ( 30643258) Haemorrhoidal disease ( 33888516) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 28552196 34021172) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Oily fish consumption ( 32066663) Platelet count ( 32888494) Plateletcrit ( 32888494) Pork consumption ( 32066663) Total cholesterol levels ( 29083408) Type 2 diabetes ( 32499647 30297969)
Interacting Genes		58 interacting genes: ACTN2 AKAP9 APP BDKRB1 CALM1 CAMK2A CAMK2G CANX CDH2 CIT CLTC CTNNB1 DLG1 DLG2 DLG3 DLG4 DLGAP4 DNM1 DRD1 DUSP4 EPHB2 EPHB4 FUS FYN GRIN2A GRIN2B GRIN2D GRIN3A HNRNPU HRAS HSPA1A INA LNX1 LRP8 MAP2 MAP2K2 MYH9 NANOS1 NEFL NF1 NR1H4 PLAT PLCG1 PPP2R1A PPP2R2A PRKCA PRKCB PRKCE PRKCG PTAFR RAP2A RPS6KA3 SP3 SPTAN1 SYNGAP1 TJP1 TRAF3 TUBA4B	17 interacting genes: AKT1 APP CLK1 DNAJC7 EFS EPHA2 GRIN1 GRIN2D HRAS HTR6 LIMK2 MAP2K3 RAF1 SDC2 SOX4 TBPL1 VCP
Entrez ID		2902	4763
HPRD ID		15926	01203
Ensembl ID		ENSG00000176884	ENSG00000196712
Uniprot IDs		Q05586 Q59GW0 Q5VSF9	P21359
PDB IDs		2HQW 2NR1 3BYA 5H8F 5H8H 5H8N 5H8Q 5I2K 5I2N 5KCJ 5KDT 5TP9 5TPA 6IRA 6IRF 6IRG 6IRH 7EOQ 7EOR 7EOS 7EOT 7EOU 7EU7 7EU8 7YFF 7YFL 7YFM 7YFO 7YFR 8E92 8E93 8E94 8E96 8E97 8E98 8E99 8JIZ 8JJ0 8JJ1 8JJ2 8UUE 8VUL 8VUN 8VUQ 8VUR 8VUS 8VUT 8VUU 8VUV 8Y1V 9D37 9D38 9D39 9D3A 9D3B 9D3C 9GIB 9GIC 9GID 9GIE 9GIF 9GIG 9GJ1	1NF1 2D4Q 2E2X 3P7Z 3PEG 3PG7 6OB2 6OB3 6V65 6V6F 7MOC 7MP5 7MP6 7PGP 7PGQ 7PGR 7PGS 7PGT 7PGU 7R03 7R04 8E20 8EDL 8EDM 8EDN 8EDO
Enriched GO Terms of Interacting Partners?		Modulation Of Chemical Synaptic Transmission Glutamatergic Synapse Regulation Of Neuronal Synaptic Plasticity Regulation Of Biological Quality Regulation Of Synaptic Plasticity Trans-synaptic Signaling Synaptic Signaling Positive Regulation Of Synaptic Transmission Chemical Synaptic Transmission Regulation Of Cellular Component Organization Long-term Synaptic Potentiation Neuron Projection Synapse Signaling Postsynaptic Density Membrane Cell Communication Regulation Of Monoatomic Ion Transport Regulation Of Cell Communication Regulation Of Signaling Cell-cell Signaling Regulation Of Transport Synaptic Membrane Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Anatomical Structure Morphogenesis Regulation Of Synapse Organization Glutamate Receptor Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Signal Transduction Plasma Membrane Postsynaptic Density Regulation Of Metal Ion Transport Regulation Of Cellular Localization Learning Or Memory Cell Projection Protein Kinase Binding Regulation Of Apoptotic Process Cell Junction Organization NMDA Glutamate Receptor Activity Regulation Of Calcium Ion Transport Dendrite Ligand-gated Ion Channel Signaling Pathway Regulation Of Protein Localization Developmental Process Regulation Of Protein Localization To Membrane Regulation Of Programmed Cell Death Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cognition	Intracellular Signaling Cassette Positive Regulation Of Signal Transduction Regulation Of Neuronal Synaptic Plasticity Glial Cell Development Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Signal Transduction Protein Kinase Activity Regulation Of Intracellular Signal Transduction Ligand-gated Ion Channel Signaling Pathway Positive Regulation Of Phosphate Metabolic Process Cellular Response To Oxygen-containing Compound Modulation Of Excitatory Postsynaptic Potential Regulation Of Protein Localization Glutamate Receptor Signaling Pathway NMDA Glutamate Receptor Activity Glutamate Binding Protein Serine Kinase Activity Regulation Of Cell Communication Regulation Of Signaling Kinase Activity Regulation Of Plasma Membrane Bounded Cell Projection Organization Excitatory Postsynaptic Potential NMDA Selective Glutamate Receptor Complex Glutamate-gated Calcium Ion Channel Activity Regulation Of MAPK Cascade Regulation Of Cell Projection Organization Protein Serine/threonine Kinase Activity Excitatory Chemical Synaptic Transmission Regulation Of Synaptic Plasticity Regulation Of Membrane Potential Positive Regulation Of Protein Localization Response To Radiation Insulin Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Projection Assembly Positive Regulation Of Intracellular Signal Transduction Regulation Of Postsynaptic Membrane Potential Nucleotide Binding Schwann Cell Development Cell Development Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cell Migration Developmental Process Regulation Of Phosphorus Metabolic Process Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Peptidyl-serine Phosphorylation
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