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GRIN1 and TRAF3
Number of citations of the paper that reports this interaction (PubMedID
10862698
)
0
Data Source:
HPRD
(in vivo)
GRIN1
TRAF3
Description
glutamate ionotropic receptor NMDA type subunit 1
TNF receptor associated factor 3
Image
GO Annotations
Cellular Component
Cytoplasm
Endoplasmic Reticulum Membrane
Plasma Membrane
Synaptic Vesicle
Cell Surface
Postsynaptic Density
Membrane
NMDA Selective Glutamate Receptor Complex
Dendrite
Monoatomic Ion Channel Complex
Neuron Projection
Synaptic Cleft
Terminal Bouton
Dendritic Spine
Synapse
Postsynaptic Membrane
Excitatory Synapse
Synaptic Membrane
Postsynaptic Density Membrane
Neurotransmitter Receptor Complex
Ubiquitin Ligase Complex
Cytoplasm
Mitochondrion
Endosome
Cytosol
Cytoplasmic Side Of Plasma Membrane
Endosome Membrane
Membrane
CD40 Receptor Complex
Serine/threonine Protein Kinase Complex
Molecular Function
Amyloid-beta Binding
NMDA Glutamate Receptor Activity
Monoatomic Ion Channel Activity
Calcium Channel Activity
Calcium Ion Binding
Protein Binding
Calmodulin Binding
Ligand-gated Monoatomic Ion Channel Activity
Ligand-gated Sodium Channel Activity
Glycine Binding
Glutamate Binding
Glutamate-gated Calcium Ion Channel Activity
Signaling Receptor Activity
Protein-containing Complex Binding
Metal Ion Binding
Glycine-gated Cation Channel Activity
Ubiquitin-protein Transferase Activity
Tumor Necrosis Factor Receptor Binding
Protein Binding
Zinc Ion Binding
Transferase Activity
Protein Kinase Binding
Protein Phosphatase Binding
Ubiquitin Protein Ligase Binding
Thioesterase Binding
Signaling Adaptor Activity
Identical Protein Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Biological Process
Monoatomic Ion Transport
Monoatomic Cation Transport
Chemical Synaptic Transmission
Brain Development
Visual Learning
Positive Regulation Of Calcium Ion Transport Into Cytosol
Propylene Metabolic Process
Calcium-mediated Signaling
Monoatomic Ion Transmembrane Transport
Ionotropic Glutamate Receptor Signaling Pathway
Sodium Ion Transmembrane Transport
Regulation Of Membrane Potential
Response To Ethanol
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Synaptic Plasticity
Regulation Of Neuronal Synaptic Plasticity
Protein Heterotetramerization
Positive Regulation Of Synaptic Transmission, Glutamatergic
Calcium Ion Homeostasis
Excitatory Postsynaptic Potential
Calcium Ion Transmembrane Transport
Calcium Ion Transmembrane Import Into Cytosol
Monoatomic Cation Transmembrane Transport
Excitatory Chemical Synaptic Transmission
Positive Regulation Of Reactive Oxygen Species Biosynthetic Process
Regulation Of Monoatomic Cation Transmembrane Transport
Cellular Response To Amyloid-beta
Response To Glycine
Positive Regulation Of Excitatory Postsynaptic Potential
Regulation Of Cytokine Production
Toll-like Receptor Signaling Pathway
Immune System Process
Apoptotic Process
Signal Transduction
Cell Surface Receptor Signaling Pathway
Toll Signaling Pathway
MRNA Transcription
Regulation Of Proteolysis
Negative Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Type I Interferon Production
Positive Regulation Of Type I Interferon Production
Regulation Of Interferon-beta Production
Tumor Necrosis Factor-mediated Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Regulation Of Apoptotic Process
Regulation Of Canonical NF-kappaB Signal Transduction
Innate Immune Response
Regulation Of Defense Response To Virus
Defense Response To Virus
Type I Interferon-mediated Signaling Pathway
Antiviral Innate Immune Response
Pathways
EPHB-mediated forward signaling
EPHB-mediated forward signaling
Unblocking of NMDA receptors, glutamate binding and activation
Unblocking of NMDA receptors, glutamate binding and activation
Ras activation upon Ca2+ influx through NMDA receptor
RAF/MAP kinase cascade
Neurexins and neuroligins
Synaptic adhesion-like molecules
Assembly and cell surface presentation of NMDA receptors
Assembly and cell surface presentation of NMDA receptors
Negative regulation of NMDA receptor-mediated neuronal transmission
Long-term potentiation
TRAF3 deficiency - HSE
TNFR2 non-canonical NF-kB pathway
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Ovarian tumor domain proteases
TICAM1-dependent activation of IRF3/IRF7
TRAF3-dependent IRF activation pathway
Negative regulators of DDX58/IFIH1 signaling
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)
SARS-CoV-1 activates/modulates innate immune responses
SARS-CoV-2 activates/modulates innate and adaptive immune responses
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation
Drugs
Glutamic acid
Tramadol
Enflurane
Atomoxetine
Pentobarbital
Methadone
Secobarbital
Meperidine
Dextropropoxyphene
Acamprosate
Donepezil
Guaifenesin
Memantine
Memantine
Orphenadrine
Phenobarbital
Aripiprazole
Prasterone
5,7-Dichlorokynurenic acid
D-Serine
Cycloleucine
Milnacipran
CNS-5161
Acetylcysteine
Ketobemidone
Gavestinel
Agmatine
Ifenprodil
Magnesium acetate tetrahydrate
Magnesium carbonate
Esketamine
Fluciclovine (18F)
Diseases
GWAS
Post-traumatic stress disorder (asjusted for relatedness) (
23726511
)
Adult body size (
32376654
)
Age at first birth (
34211149
)
Age at first sexual intercourse (
34211149
)
Albumin-globulin ratio (
29403010
)
Allergic disease (asthma, hay fever and/or eczema) (age of onset) (
32603359
)
Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) (
32603359
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Apolipoprotein A1 levels (
32203549
)
Asthma (
32296059
)
Asthma (childhood onset) (
30929738
)
Body mass index (
29273807
25673413
)
Body size at age 10 (
32376654
)
Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) (
19023125
)
Composite immunoglobulin trait (IgA x IgG/IgM) (
28628107
)
Eczema (
31361310
)
Gallstone disease (
30692554
)
Gastroesophageal reflux disease, peptic ulcer disease and/or corresponding medications and treatment (
33608531
)
HDL cholesterol levels (
32203549
)
Immunoglobulin measurement (zinc sulfate turbidity test) (
29403010
)
Lymphocyte count (
27863252
32888494
)
Lymphocyte percentage of white cells (
27863252
32888494
)
Major depressive disorder (MTAG) (
33479212
)
Monocyte count (
32888494
)
Multiple sclerosis (
24076602
31604244
)
Neutrophil percentage of white cells (
32888494
)
Non-albumin protein levels (
29403010
)
Red blood cell count (
32888494
)
Serum total protein levels (
29403010
)
Systemic lupus erythematosus (
33536424
28714469
)
Type 2 diabetes (
32499647
)
Interacting Genes
58 interacting genes:
ACTN2
AKAP9
APP
BDKRB1
CALM1
CAMK2A
CAMK2G
CANX
CDH2
CIT
CLTC
CTNNB1
DLG1
DLG2
DLG3
DLG4
DLGAP4
DNM1
DRD1
DUSP4
EPHB2
EPHB4
FUS
FYN
GRIN2A
GRIN2B
GRIN2D
GRIN3A
HNRNPU
HRAS
HSPA1A
INA
LNX1
LRP8
MAP2
MAP2K2
MYH9
NANOS1
NEFL
NF1
NR1H4
PLAT
PLCG1
PPP2R1A
PPP2R2A
PRKCA
PRKCB
PRKCE
PRKCG
PTAFR
RAP2A
RPS6KA3
SP3
SPTAN1
SYNGAP1
TJP1
TRAF3
TUBA4B
86 interacting genes:
ABCC1
ALPL
APOBEC3C
ASCC1
AZI2
BEX3
BIVM
C10orf62
CASP3
CCDC13
CCDC184
CD27
CD40
CDC37
CELF2
DAXX
EDA2R
EDAR
EWSR1
FAS
GMEB2
GRIN1
GRIN2D
HEMGN
HNRNPC
IFT25
IL15
IP6K3
IRF1
LNX1
LTBR
MAP2K1
MAP3K14
MAP3K7
MAVS
MFF
NEDD4L
NTAQ1
NUP62
OTUD5
PDLIM7
PDZD4
PIAS2
POM121
PSMB8
PTPN6
RAD23A
RIPK1
RIPPLY1
RNF216
RNF4
RRAS2
SAR1A
SHANK3
SRC
STK38
TANK
TBK1
TDP2
TICAM1
TNFRSF11A
TNFRSF12A
TNFRSF13C
TNFRSF14
TNFRSF17
TNFRSF18
TNFRSF19
TNFRSF1A
TNFRSF1B
TNFRSF4
TNFRSF8
TNFRSF9
TRADD
TRAF2
TRAF3IP1
TRAF3IP2
TRAF3IP3
TRAF5
TRIM24
TRIM37
UBE2I
USP7
ZBP1
ZBTB49
ZMYND11
ZSCAN4
Entrez ID
2902
7187
HPRD ID
15926
03539
Ensembl ID
ENSG00000176884
ENSG00000131323
Uniprot IDs
Q05586
Q59GW0
Q5VSF9
A6NHG8
Q13114
PDB IDs
2HQW
2NR1
3BYA
5H8F
5H8H
5H8N
5H8Q
5I2K
5I2N
5KCJ
5KDT
5TP9
5TPA
6IRA
6IRF
6IRG
6IRH
7EOQ
7EOR
7EOS
7EOT
7EOU
7EU7
7EU8
7YFF
7YFL
7YFM
7YFO
7YFR
8E92
8E93
8E94
8E96
8E97
8E98
8E99
8JIZ
8JJ0
8JJ1
8JJ2
8UUE
8VUL
8VUN
8VUQ
8VUR
8VUS
8VUT
8VUU
8VUV
8Y1V
9D37
9D38
9D39
9D3A
9D3B
9D3C
9GIB
9GIC
9GID
9GIE
9GIF
9GIG
9GJ1
1FLK
1FLL
1KZZ
1L0A
1RF3
1ZMS
2ECY
2GKW
8T5P
Enriched GO Terms of Interacting Partners
?
Modulation Of Chemical Synaptic Transmission
Glutamatergic Synapse
Regulation Of Neuronal Synaptic Plasticity
Regulation Of Biological Quality
Regulation Of Synaptic Plasticity
Trans-synaptic Signaling
Synaptic Signaling
Positive Regulation Of Synaptic Transmission
Chemical Synaptic Transmission
Regulation Of Cellular Component Organization
Long-term Synaptic Potentiation
Neuron Projection
Synapse
Signaling
Postsynaptic Density Membrane
Cell Communication
Regulation Of Monoatomic Ion Transport
Regulation Of Cell Communication
Regulation Of Signaling
Cell-cell Signaling
Regulation Of Transport
Synaptic Membrane
Regulation Of Monoatomic Cation Transmembrane Transport
Regulation Of Monoatomic Ion Transmembrane Transport
Regulation Of Long-term Neuronal Synaptic Plasticity
Regulation Of Anatomical Structure Morphogenesis
Regulation Of Synapse Organization
Glutamate Receptor Signaling Pathway
Ionotropic Glutamate Receptor Signaling Pathway
Signal Transduction
Plasma Membrane
Postsynaptic Density
Regulation Of Metal Ion Transport
Regulation Of Cellular Localization
Learning Or Memory
Cell Projection
Protein Kinase Binding
Regulation Of Apoptotic Process
Cell Junction Organization
NMDA Glutamate Receptor Activity
Regulation Of Calcium Ion Transport
Dendrite
Ligand-gated Ion Channel Signaling Pathway
Regulation Of Protein Localization
Developmental Process
Regulation Of Protein Localization To Membrane
Regulation Of Programmed Cell Death
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Cognition
Tumor Necrosis Factor-mediated Signaling Pathway
Cytokine-mediated Signaling Pathway
Tumor Necrosis Factor Receptor Activity
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Cell Surface Receptor Signaling Pathway
Apoptotic Process
Cell Death
Programmed Cell Death
Signal Transduction
Positive Regulation Of Signal Transduction
Regulation Of Defense Response
Tumor Necrosis Factor Receptor Superfamily Complex
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Regulation Of Type I Interferon Production
Regulation Of Cytokine-mediated Signaling Pathway
Regulation Of Cytokine Production
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Intracellular Signal Transduction
Extrinsic Apoptotic Signaling Pathway
Apoptotic Signaling Pathway
Positive Regulation Of Defense Response
Signaling Receptor Activity
Positive Regulation Of Gene Expression
Death-inducing Signaling Complex
Defense Response To Virus
Regulation Of Cell Communication
Regulation Of Signaling
Ubiquitin Protein Ligase Binding
Regulation Of Macromolecule Metabolic Process
Regulation Of Mononuclear Cell Proliferation
Regulation Of JNK Cascade
Cellular Response To Mechanical Stimulus
Regulation Of Gene Expression
Intracellular Signal Transduction
Response To Stress
Positive Regulation Of Metabolic Process
Regulation Of Metabolic Process
CD40 Signaling Pathway
Regulation Of Leukocyte Proliferation
Regulation Of Immune System Process
Regulation Of MAPK Cascade
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Multicellular Organismal Process
Positive Regulation Of Cytokine Production
Immune Response
Response To External Biotic Stimulus
Positive Regulation Of Type I Interferon Production
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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