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GRIN1 and TRAF3
Number of citations of the paper that reports this interaction (PMID
10862698
)
203
Data Source:
HPRD
(in vivo)
GRIN1
TRAF3
Gene Name
glutamate receptor, ionotropic, N-methyl D-aspartate 1
TNF receptor-associated factor 3
Image
Gene Ontology Annotations
Cellular Component
Endoplasmic Reticulum
Plasma Membrane
Integral Component Of Plasma Membrane
Synaptic Vesicle
Cell Surface
Postsynaptic Density
N-methyl-D-aspartate Selective Glutamate Receptor Complex
Cell Junction
Dendrite
Dendrite Membrane
Neuron Projection
Synaptic Cleft
Terminal Bouton
Dendritic Spine
Synapse
Postsynaptic Membrane
Excitatory Synapse
Neuronal Postsynaptic Density
Mitochondrion
Endosome
Cytosol
Cytoplasmic Side Of Plasma Membrane
CD40 Receptor Complex
Molecular Function
N-methyl-D-aspartate Selective Glutamate Receptor Activity
Extracellular-glutamate-gated Ion Channel Activity
Calcium Channel Activity
Calcium Ion Binding
Protein Binding
Calmodulin Binding
Glycine Binding
Glutamate Binding
Enzyme Binding
Voltage-gated Cation Channel Activity
Glutamate Receptor Binding
Neurotransmitter Binding
Protein Heterodimerization Activity
Ubiquitin-protein Transferase Activity
Signal Transducer Activity
Tumor Necrosis Factor Receptor Binding
Protein Binding
Zinc Ion Binding
Ligase Activity
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Thioesterase Binding
Biological Process
Conditioned Taste Aversion
Suckling Behavior
Response To Amphetamine
Cation Transport
Cellular Calcium Ion Homeostasis
Synaptic Transmission
Axon Guidance
Respiratory Gaseous Exchange
Long-term Memory
Adult Locomotory Behavior
Olfactory Learning
Visual Learning
Propylene Metabolic Process
Sensory Perception Of Pain
Pons Maturation
Cerebral Cortex Development
Ion Transmembrane Transport
Regulation Of Ion Transmembrane Transport
Social Behavior
Ionotropic Glutamate Receptor Signaling Pathway
Synaptic Transmission, Glutamatergic
Regulation Of Membrane Potential
Positive Regulation Of Apoptotic Process
Response To Morphine
Negative Regulation Of Neuron Apoptotic Process
Regulation Of Respiratory Gaseous Exchange
Response To Ethanol
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Ephrin Receptor Signaling Pathway
Regulation Of Long-term Neuronal Synaptic Plasticity
Rhythmic Process
Regulation Of Dendrite Morphogenesis
Regulation Of Axonogenesis
Protein Tetramerization
Response To Calcium Ion
Regulation Of Synapse Assembly
Calcium Ion Homeostasis
Regulation Of Excitatory Postsynaptic Membrane Potential
Prepulse Inhibition
Male Mating Behavior
Response To Fungicide
Calcium Ion Transmembrane Transport
Cellular Response To Manganese Ion
Positive Regulation Of Excitatory Postsynaptic Membrane Potential
Regulation Of Cytokine Production
Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Apoptotic Process
Signal Transduction
Toll Signaling Pathway
Protein Ubiquitination
Regulation Of Proteolysis
Negative Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Type I Interferon Production
Regulation Of Interferon-beta Production
Tumor Necrosis Factor-mediated Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Regulation Of Apoptotic Process
Innate Immune Response
Regulation Of Defense Response To Virus
Pathways
EPHB-mediated forward signaling
Axon guidance
Activation of NMDA receptor upon glutamate binding and postsynaptic events
CREB phosphorylation through the activation of CaMKII
EPH-Ephrin signaling
CREB phosphorylation through the activation of Ras
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Unblocking of NMDA receptor, glutamate binding and activation
Ras activation uopn Ca2+ infux through NMDA receptor
Post NMDA receptor activation events
Transmission across Chemical Synapses
Activated TLR4 signalling
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
TRAF3-dependent IRF activation pathway
Toll-Like Receptors Cascades
Negative regulators of RIG-I/MDA5 signaling
TRIF-mediated TLR3/TLR4 signaling
Toll Like Receptor 4 (TLR4) Cascade
Toll Like Receptor 3 (TLR3) Cascade
MyD88-independent cascade
Innate Immune System
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Drugs
L-Glutamic Acid
Meperidine
Orphenadrine
Dcka, 5,7-Dichlorokynurenic Acid
D-Serine
Cycloleucine
Milnacipran
Agmatine
Diseases
GWAS
Post-traumatic stress disorder (asjusted for relatedness) (
23726511
)
Brain imaging in schizophrenia (interaction) (
19023125
)
Protein-Protein Interactions
53 interactors:
ACTN2
AKAP9
CALM1
CAMK2A
CAMK2G
CANX
CDH2
CIT
CLTC
CTNNB1
DLG2
DLG3
DLG4
DLGAP4
DNM1
DRD1
DUSP4
EPHB2
EPHB4
FUS
FYN
GRIN2A
GRIN2B
GRIN2D
GRIN3A
HNRNPU
HRAS
HSPA1A
INA
LNX1
LRP8
MAP2
MAP2K2
MYH9
NANOS1
NEFL
NF1
PLAT
PLCG1
PPP2R1A
PPP2R2A
PRKCA
PRKCB
PRKCE
PRKCG
RAP2A
RPS6KA3
SP3
SPTAN1
SYNGAP1
TJP1
TRAF3
TUBA4B
55 interactors:
ABCC1
ALPL
APOBEC3C
AZI2
BIRC3
CASP3
CD27
CD40
DAXX
EDA2R
EDAR
EWSR1
FAS
GRIN1
GRIN2D
IL15
IRF1
LTBR
MAP2K1
MAP3K14
NGFRAP1
NUP62
OTUD5
PDLIM7
RIPK1
RRAS2
SAR1A
SRC
TANK
TBK1
TDP2
TICAM1
TNFRSF11A
TNFRSF12A
TNFRSF13C
TNFRSF14
TNFRSF17
TNFRSF18
TNFRSF19
TNFRSF1A
TNFRSF1B
TNFRSF4
TNFRSF8
TNFRSF9
TRADD
TRAF2
TRAF3IP1
TRAF3IP2
TRAF3IP3
TRAF5
TRIM37
UBE2I
USP7
ZBP1
ZMYND11
Entrez ID
2902
7187
HPRD ID
15926
03539
Ensembl ID
ENSG00000176884
ENSG00000131323
Uniprot IDs
Q05586
Q59GW0
Q5VSF9
A6NHG8
Q13114
PDB IDs
2HQW
2NR1
3BYA
1FLK
1FLL
1KZZ
1L0A
1RF3
1ZMS
2ECY
2GKW
Enriched GO Terms of Interacting Partners
?
Synaptic Transmission
Cell-cell Signaling
Nervous System Development
Signaling
Locomotion
Cell Communication
Neurogenesis
Cell Differentiation
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Response To Organic Substance
Generation Of Neurons
Neuron Projection Development
Neuron Development
Developmental Process
Cell Development
Neuron Differentiation
Response To External Stimulus
Signal Transduction
Cell Projection Organization
Movement Of Cell Or Subcellular Component
Enzyme Linked Receptor Protein Signaling Pathway
Multicellular Organismal Development
System Development
Cellular Response To Stimulus
Anatomical Structure Development
Axon Development
Axon Guidance
Regulation Of Synaptic Transmission
Regulation Of Synaptic Plasticity
Neuron Projection Morphogenesis
Cell Surface Receptor Signaling Pathway
Axonogenesis
Cellular Response To Organic Substance
Response To Wounding
Cell Morphogenesis Involved In Neuron Differentiation
Cell Morphogenesis Involved In Differentiation
Learning
Response To Stimulus
Regulation Of Signaling
Chemotaxis
Neurotrophin TRK Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Response To Abiotic Stimulus
Fibroblast Growth Factor Receptor Signaling Pathway
Blood Coagulation
Hemostasis
Cell Projection Morphogenesis
Single-organism Behavior
Cellular Response To Growth Factor Stimulus
Learning Or Memory
Cell Death
Death
Tumor Necrosis Factor-mediated Signaling Pathway
Programmed Cell Death
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Apoptotic Process
Response To Tumor Necrosis Factor
Cellular Response To Tumor Necrosis Factor
Regulation Of Cytokine Production
Signal Transduction
Positive Regulation Of Protein Metabolic Process
Immune System Process
Regulation Of Protein Metabolic Process
Cellular Response To Stimulus
Extrinsic Apoptotic Signaling Pathway
Signaling
Regulation Of Signal Transduction
Cell Communication
Regulation Of Signaling
Response To Stimulus
Immune Response
Regulation Of Cell Death
Positive Regulation Of Cellular Metabolic Process
Regulation Of Intracellular Signal Transduction
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Cytokine Production
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Cellular Process
Regulation Of Apoptotic Process
Response To Cytokine
Regulation Of Immune System Process
Regulation Of Phosphorylation
Regulation Of Lymphocyte Activation
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Apoptotic Signaling Pathway
Cytokine-mediated Signaling Pathway
Regulation Of Phosphorus Metabolic Process
Cellular Response To Organic Substance
Response To Organic Substance
Cellular Response To Cytokine Stimulus
Regulation Of Cell Activation
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Cell Death
Tagcloud
?
adhesion
affinity
bind
cd40
cd40ct
cytoplasmic
dispensable
dominantly
extensive
icam
ikappabalpha
implicated
incapable
intercellular
jak3
kappab
mediators
molecule
much
mutants
necrosis
residues
strongly
tail
traf2
traf5
traf6
transduction
Tagcloud (Difference)
?
adhesion
affinity
bind
cd40
cd40ct
cytoplasmic
dispensable
dominantly
extensive
icam
ikappabalpha
implicated
incapable
intercellular
jak3
kappab
mediators
molecule
much
mutants
necrosis
residues
strongly
tail
traf2
traf5
traf6
transduction
Tagcloud (Intersection)
?