MYH9 and MYOM1

Number of citations of the paper that reports this interaction (PMID 7588733)
7

Data Source:
HPRD (in vitro)

		MYH9	MYOM1
Gene Name		myosin, heavy chain 9, non-muscle	myomesin 1
Image
Gene Ontology Annotations	Cellular Component	Stress Fiber Ruffle Immunological Synapse Uropod Nucleus Cytoplasm Spindle Actomyosin Contractile Ring Cytosol Plasma Membrane Cell-cell Adherens Junction COP9 Signalosome Integrin Complex Actin Cytoskeleton Membrane Myosin II Complex Cortical Cytoskeleton Cell Leading Edge Neuromuscular Junction Cleavage Furrow Actomyosin Protein Complex Extracellular Vesicular Exosome Myosin II Filament	Striated Muscle Myosin Thick Filament M Band
	Molecular Function	Microfilament Motor Activity Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding ATPase Activity Actin-dependent ATPase Activity Protein Homodimerization Activity Protein Anchor ADP Binding Poly(A) RNA Binding Actin Filament Binding	Protein Binding Structural Constituent Of Muscle Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Meiotic Spindle Organization Cytokinesis Angiogenesis In Utero Embryonic Development Establishment Of T Cell Polarity Membrane Protein Ectodomain Proteolysis Integrin-mediated Signaling Pathway Axon Guidance Myoblast Fusion Regulation Of Cell Shape Protein Transport Actin Filament-based Movement Platelet Formation Monocyte Differentiation Actomyosin Structure Organization Actin Cytoskeleton Reorganization Uropod Organization Termination Of G-protein Coupled Receptor Signaling Pathway Blood Vessel Endothelial Cell Migration Ephrin Receptor Signaling Pathway Leukocyte Migration Establishment Of Meiotic Spindle Localization Platelet Aggregation	Muscle Contraction
Pathways		EPHA-mediated growth cone collapse Axon guidance Semaphorin interactions EPH-Ephrin signaling Sema4D in semaphorin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Sema4D induced cell migration and growth-cone collapse Innate Immune System
Drugs
Diseases
GWAS		End-stage renal disease (non-diabetic) ( 20532800) Glomerulosclerosis ( 20668430) Optic disc size (rim) ( 20395239)
Protein-Protein Interactions		22 interactors: ASCC2 CASP4 CBL CD163 CSNK2A1 CXCR4 GRB2 GRIN1 MEN1 MYBPC3 MYH10 MYL9 MYOM1 MYOM2 OVGP1 PPP2CA PTPN6 RAC1 S100A4 TTN TUFM YWHAZ	2 interactors: MYH9 TTN
Entrez ID		4627	8736
HPRD ID		01177	04618
Ensembl ID		ENSG00000100345	ENSG00000101605
Uniprot IDs		P35579	P52179
PDB IDs		2LNK 3ZWH 4ETO	2R15 2Y23 2Y25 3RBS
Enriched GO Terms of Interacting Partners?		Cell Morphogenesis Involved In Differentiation Cell Development Platelet Activation Axon Guidance Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Morphogenesis Movement Of Cell Or Subcellular Component Anatomical Structure Morphogenesis Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Wound Healing Chemotaxis Locomotion Positive Regulation Of Signal Transduction Neuron Projection Morphogenesis Apoptotic Process Muscle Contraction Cell Activation Blood Coagulation Programmed Cell Death Hemostasis Ephrin Receptor Signaling Pathway Response To Wounding Cell Death Death Muscle System Process Neuron Projection Development Cell Projection Morphogenesis Myosin Filament Assembly Cell Part Morphogenesis Regulation Of Body Fluid Levels Cell Differentiation Neuron Development Regulation Of Cellular Component Organization Actin Filament-based Movement Regulation Of Signaling Cell Surface Receptor Signaling Pathway Endomembrane System Organization Neuron Differentiation T Cell Costimulation Myofibril Assembly Leukocyte Migration Brain Development Cell Projection Organization Regulation Of Kinase Activity Head Development Regulation Of Signal Transduction Anatomical Structure Development	Actin Filament-based Movement Actomyosin Structure Organization Platelet Activation Striated Muscle Cell Differentiation Muscle Cell Differentiation Sarcomerogenesis Detection Of Muscle Stretch Skeletal Muscle Myosin Thick Filament Assembly Directional Locomotion Blood Coagulation Hemostasis Myosin Filament Assembly Establishment Of T Cell Polarity Uropod Organization Establishment Of Meiotic Spindle Localization Muscle Structure Development In Utero Embryonic Development Skeletal Muscle Thin Filament Assembly Regulation Of Body Fluid Levels Wound Healing Actin Cytoskeleton Organization Cardiac Muscle Fiber Development Response To Muscle Stretch Skeletal Myofibril Assembly Actin Filament-based Process Cell Activation Response To Wounding Meiotic Spindle Organization Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Cardiovascular System Development Adult Heart Development Monocyte Differentiation Membrane Protein Ectodomain Proteolysis Myoblast Fusion Platelet Formation Cardiac Myofibril Assembly Platelet Morphogenesis Cell Cycle Process Anatomical Structure Formation Involved In Morphogenesis Cardiac Muscle Hypertrophy Mitotic Chromosome Condensation Cytoskeleton Organization Muscle Hypertrophy Embryo Development Muscle Filament Sliding Actin-myosin Filament Sliding Syncytium Formation Blood Vessel Endothelial Cell Migration Locomotion
Tagcloud ?		abundance acetylation attempt capability cognate consolidate coordinating cytoplasmic deacetylase deacetylation diversity dnaj dnaja1 elucidated hdac6 homolog hsc70 knockout modulates monitor myosin negatively notion participates predominantly proteomic serves subfamily verified	18p11 aided blindness cataracts centimorgans chorioretinal clul1 compiled dlgap1 elastin emilin2 interfacer intronic lipin lpin2 microfibril mrcl3 mrlc2 myomesin myopia myosin myp2 pedigree positional prioritizing segregated tgifbeta underway zfp161
Tagcloud (Difference) ?		abundance acetylation attempt capability cognate consolidate coordinating cytoplasmic deacetylase deacetylation diversity dnaj dnaja1 elucidated hdac6 homolog hsc70 knockout modulates monitor negatively notion participates predominantly proteomic serves subfamily verified	18p11 aided blindness cataracts centimorgans chorioretinal clul1 compiled dlgap1 elastin emilin2 interfacer intronic lipin lpin2 microfibril mrcl3 mrlc2 myomesin myopia myp2 pedigree positional prioritizing segregated tgifbeta underway zfp161
Tagcloud (Intersection) ?		myosin