MYH9 and MYH10

Number of citations of the paper that reports this interaction (PMID 22939629)
44

Data Source:
BioGRID (biochemical)
HPRD (two hybrid, in vivo)

		MYH9	MYH10
Gene Name		myosin, heavy chain 9, non-muscle	myosin, heavy chain 10, non-muscle
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Stress Fiber Ruffle Immunological Synapse Uropod Nucleus Cytoplasm Spindle Actomyosin Contractile Ring Cytosol Plasma Membrane Cell-cell Adherens Junction COP9 Signalosome Integrin Complex Actin Cytoskeleton Membrane Myosin II Complex Cortical Cytoskeleton Cell Leading Edge Neuromuscular Junction Cleavage Furrow Actomyosin Protein Complex Extracellular Vesicular Exosome Myosin II Filament	Stress Fiber Nucleus Cytoplasm Mitochondrion Spindle Plasma Membrane Cell Cortex Actin Cytoskeleton Myosin Complex Myosin II Complex Lamellipodium Axon Growth Cone Midbody Neuromuscular Junction Cleavage Furrow Actomyosin Neuronal Cell Body Dendritic Spine Extracellular Vesicular Exosome Myosin II Filament
	Molecular Function	Microfilament Motor Activity Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding ATPase Activity Actin-dependent ATPase Activity Protein Homodimerization Activity Protein Anchor ADP Binding Poly(A) RNA Binding Actin Filament Binding	Microfilament Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding Actin-dependent ATPase Activity ADP Binding Actin Filament Binding
	Biological Process	Meiotic Spindle Organization Cytokinesis Angiogenesis In Utero Embryonic Development Establishment Of T Cell Polarity Membrane Protein Ectodomain Proteolysis Integrin-mediated Signaling Pathway Axon Guidance Myoblast Fusion Regulation Of Cell Shape Protein Transport Actin Filament-based Movement Platelet Formation Monocyte Differentiation Actomyosin Structure Organization Actin Cytoskeleton Reorganization Uropod Organization Termination Of G-protein Coupled Receptor Signaling Pathway Blood Vessel Endothelial Cell Migration Ephrin Receptor Signaling Pathway Leukocyte Migration Establishment Of Meiotic Spindle Localization Platelet Aggregation	Mitotic Cytokinesis In Utero Embryonic Development Neuron Migration Plasma Membrane Repair Exocytosis Substrate-dependent Cell Migration, Cell Extension Nuclear Migration Cell Adhesion Axon Guidance Adult Heart Development Cell Proliferation Regulation Of Cell Shape Fourth Ventricle Development Lateral Ventricle Development Third Ventricle Development Cerebellar Purkinje Cell Layer Development Actin Filament-based Movement Actomyosin Structure Organization Ephrin Receptor Signaling Pathway Neuromuscular Process Controlling Balance Cardiac Myofibril Assembly Ventricular Cardiac Muscle Cell Development Retina Development In Camera-type Eye
Pathways		EPHA-mediated growth cone collapse Axon guidance Semaphorin interactions EPH-Ephrin signaling Sema4D in semaphorin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Sema4D induced cell migration and growth-cone collapse Innate Immune System	EPHA-mediated growth cone collapse Axon guidance Semaphorin interactions EPH-Ephrin signaling Sema4D in semaphorin signaling Sema4D induced cell migration and growth-cone collapse
Drugs
Diseases
GWAS		End-stage renal disease (non-diabetic) ( 20532800) Glomerulosclerosis ( 20668430) Optic disc size (rim) ( 20395239)
Protein-Protein Interactions		22 interactors: ASCC2 CASP4 CBL CD163 CSNK2A1 CXCR4 GRB2 GRIN1 MEN1 MYBPC3 MYH10 MYL9 MYOM1 MYOM2 OVGP1 PPP2CA PTPN6 RAC1 S100A4 TTN TUFM YWHAZ	9 interactors: APC BCAP31 KIAA0368 MYH9 PBX1 S100A4 YWHAE YWHAG ZNF512B
Entrez ID		4627	4628
HPRD ID		01177	01178
Ensembl ID		ENSG00000100345	ENSG00000133026
Uniprot IDs		P35579	B2RWP9 G1UI33 P35580 Q9BWG0
PDB IDs		2LNK 3ZWH 4ETO
Enriched GO Terms of Interacting Partners?		Cell Morphogenesis Involved In Differentiation Cell Development Platelet Activation Axon Guidance Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Morphogenesis Movement Of Cell Or Subcellular Component Anatomical Structure Morphogenesis Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Wound Healing Chemotaxis Locomotion Positive Regulation Of Signal Transduction Neuron Projection Morphogenesis Apoptotic Process Muscle Contraction Cell Activation Blood Coagulation Programmed Cell Death Hemostasis Ephrin Receptor Signaling Pathway Response To Wounding Cell Death Death Muscle System Process Neuron Projection Development Cell Projection Morphogenesis Myosin Filament Assembly Cell Part Morphogenesis Regulation Of Body Fluid Levels Cell Differentiation Neuron Development Regulation Of Cellular Component Organization Actin Filament-based Movement Regulation Of Signaling Cell Surface Receptor Signaling Pathway Endomembrane System Organization Neuron Differentiation T Cell Costimulation Myofibril Assembly Leukocyte Migration Brain Development Cell Projection Organization Regulation Of Kinase Activity Head Development Regulation Of Signal Transduction Anatomical Structure Development	Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Signal Transduction Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Cell Death Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Stem Cell Development Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Proximal/distal Pattern Formation Generation Of Neurons Regulation Of Signal Transduction Neurogenesis Thymus Development Stem Cell Differentiation Positive Regulation Of Mitochondrion Organization Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Regulation Of Signaling Somatic Stem Cell Maintenance Apoptotic Process Programmed Cell Death Execution Phase Of Apoptosis Cell Cycle Process Positive Regulation Of Organelle Organization Cell Death Death Cell Differentiation Regulation Of Mitochondrion Organization Cytokinesis Nervous System Development Regulation Of Heart Rate By Hormone Negative Regulation Of Peptidyl-serine Dephosphorylation Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process G2/M Transition Of Mitotic Cell Cycle Cell Cycle Negative Regulation Of Protein Serine/threonine Kinase Activity Protein Transport Hemopoiesis Regulation Of Apoptotic Process Establishment Of Protein Localization Stem Cell Maintenance Negative Regulation Of Odontogenesis System Development Regulation Of Proteolysis Mitotic Cell Cycle Process Regulation Of Cell Death Uropod Organization Establishment Of Meiotic Spindle Localization
Tagcloud ?		abundance acetylation attempt capability cognate consolidate coordinating cytoplasmic deacetylase deacetylation diversity dnaj dnaja1 elucidated hdac6 homolog hsc70 knockout modulates monitor myosin negatively notion participates predominantly proteomic serves subfamily verified	accordance aorta arteries atherosclerosis carotid ciclin d2 expresses functionality hemodynamic hyperplasia immunocitochemistry immunostaining intima labelling ligated ligation modulates morphometric neointimal reinforce remodelling restenosis sm22alpha stenotic thymidine transgenic tritiated vsmc
Tagcloud (Difference) ?		abundance acetylation attempt capability cognate consolidate coordinating cytoplasmic deacetylase deacetylation diversity dnaj dnaja1 elucidated hdac6 homolog hsc70 knockout monitor myosin negatively notion participates predominantly proteomic serves subfamily verified	accordance aorta arteries atherosclerosis carotid ciclin d2 expresses functionality hemodynamic hyperplasia immunocitochemistry immunostaining intima labelling ligated ligation morphometric neointimal reinforce remodelling restenosis sm22alpha stenotic thymidine transgenic tritiated vsmc
Tagcloud (Intersection) ?		modulates