MYH9 and MYL9

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid, biochemical)
HPRD (two hybrid)

		MYH9	MYL9
Gene Name		myosin, heavy chain 9, non-muscle	myosin, light chain 9, regulatory
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Stress Fiber Ruffle Immunological Synapse Uropod Nucleus Cytoplasm Spindle Actomyosin Contractile Ring Cytosol Plasma Membrane Cell-cell Adherens Junction COP9 Signalosome Integrin Complex Actin Cytoskeleton Membrane Myosin II Complex Cortical Cytoskeleton Cell Leading Edge Neuromuscular Junction Cleavage Furrow Actomyosin Protein Complex Extracellular Vesicular Exosome Myosin II Filament	Stress Fiber Cytosol Muscle Myosin Complex Z Disc
	Molecular Function	Microfilament Motor Activity Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding ATPase Activity Actin-dependent ATPase Activity Protein Homodimerization Activity Protein Anchor ADP Binding Poly(A) RNA Binding Actin Filament Binding	Calcium Ion Binding Structural Constituent Of Muscle
	Biological Process	Meiotic Spindle Organization Cytokinesis Angiogenesis In Utero Embryonic Development Establishment Of T Cell Polarity Membrane Protein Ectodomain Proteolysis Integrin-mediated Signaling Pathway Axon Guidance Myoblast Fusion Regulation Of Cell Shape Protein Transport Actin Filament-based Movement Platelet Formation Monocyte Differentiation Actomyosin Structure Organization Actin Cytoskeleton Reorganization Uropod Organization Termination Of G-protein Coupled Receptor Signaling Pathway Blood Vessel Endothelial Cell Migration Ephrin Receptor Signaling Pathway Leukocyte Migration Establishment Of Meiotic Spindle Localization Platelet Aggregation	Muscle Contraction Regulation Of Muscle Contraction Axon Guidance Ephrin Receptor Signaling Pathway Platelet Aggregation
Pathways		EPHA-mediated growth cone collapse Axon guidance Semaphorin interactions EPH-Ephrin signaling Sema4D in semaphorin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Sema4D induced cell migration and growth-cone collapse Innate Immune System	EPHA-mediated growth cone collapse Axon guidance Semaphorin interactions Smooth Muscle Contraction EPH-Ephrin signaling Sema4D in semaphorin signaling Sema4D induced cell migration and growth-cone collapse
Drugs
Diseases
GWAS		End-stage renal disease (non-diabetic) ( 20532800) Glomerulosclerosis ( 20668430) Optic disc size (rim) ( 20395239)
Protein-Protein Interactions		22 interactors: ASCC2 CASP4 CBL CD163 CSNK2A1 CXCR4 GRB2 GRIN1 MEN1 MYBPC3 MYH10 MYL9 MYOM1 MYOM2 OVGP1 PPP2CA PTPN6 RAC1 S100A4 TTN TUFM YWHAZ	2 interactors: CDC42BPA MYH9
Entrez ID		4627	10398
HPRD ID		01177	17619
Ensembl ID		ENSG00000100345	ENSG00000101335
Uniprot IDs		P35579	P24844
PDB IDs		2LNK 3ZWH 4ETO
Enriched GO Terms of Interacting Partners?		Cell Morphogenesis Involved In Differentiation Cell Development Platelet Activation Axon Guidance Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Morphogenesis Movement Of Cell Or Subcellular Component Anatomical Structure Morphogenesis Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Wound Healing Chemotaxis Locomotion Positive Regulation Of Signal Transduction Neuron Projection Morphogenesis Apoptotic Process Muscle Contraction Cell Activation Blood Coagulation Programmed Cell Death Hemostasis Ephrin Receptor Signaling Pathway Response To Wounding Cell Death Death Muscle System Process Neuron Projection Development Cell Projection Morphogenesis Myosin Filament Assembly Cell Part Morphogenesis Regulation Of Body Fluid Levels Cell Differentiation Neuron Development Regulation Of Cellular Component Organization Actin Filament-based Movement Regulation Of Signaling Cell Surface Receptor Signaling Pathway Endomembrane System Organization Neuron Differentiation T Cell Costimulation Myofibril Assembly Leukocyte Migration Brain Development Cell Projection Organization Regulation Of Kinase Activity Head Development Regulation Of Signal Transduction Anatomical Structure Development	Actin Cytoskeleton Reorganization Actomyosin Structure Organization Establishment Of Organelle Localization Organelle Localization Microtubule Cytoskeleton Organization Establishment Of T Cell Polarity Uropod Organization Establishment Of Meiotic Spindle Localization Actin Cytoskeleton Organization Actin Filament-based Process Meiotic Spindle Organization Microtubule-based Process Nuclear Migration Cell Migration Cell Motility Monocyte Differentiation Membrane Protein Ectodomain Proteolysis Myoblast Fusion Platelet Formation Platelet Morphogenesis Establishment Of Nucleus Localization Cytoskeleton Organization Syncytium Formation Blood Vessel Endothelial Cell Migration Locomotion Membrane Protein Proteolysis Platelet Aggregation Nucleus Localization Movement Of Cell Or Subcellular Component Spindle Localization Myotube Differentiation Actin Filament-based Movement Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Endothelial Cell Migration Establishment Of Localization In Cell Ephrin Receptor Signaling Pathway Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Epithelial Cell Migration Epithelium Migration Cytokinesis Establishment Of Cell Polarity Myeloid Leukocyte Differentiation Cellular Localization Integrin-mediated Signaling Pathway Spindle Organization Regulation Of Cell Shape Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Ameboidal-type Cell Migration Establishment Or Maintenance Of Cell Polarity
Tagcloud ?		abundance acetylation attempt capability cognate consolidate coordinating cytoplasmic deacetylase deacetylation diversity dnaj dnaja1 elucidated hdac6 homolog hsc70 knockout modulates monitor myosin negatively notion participates predominantly proteomic serves subfamily verified	bioinformatics bmp2 calm1 cnaq csf2rb csf3 expressions fifteen gria2 il10ra il10rb il11ra il3ra il6st lifr lymphatic microarrays mylk myosin nonsmokers nsclc paraneoplastic pathohistological plcb4 ppp2ca rac3 rock2 thbs1 verify
Tagcloud (Difference) ?		abundance acetylation attempt capability cognate consolidate coordinating cytoplasmic deacetylase deacetylation diversity dnaj dnaja1 elucidated hdac6 homolog hsc70 knockout modulates monitor negatively notion participates predominantly proteomic serves subfamily verified	bioinformatics bmp2 calm1 cnaq csf2rb csf3 expressions fifteen gria2 il10ra il10rb il11ra il3ra il6st lifr lymphatic microarrays mylk nonsmokers nsclc paraneoplastic pathohistological plcb4 ppp2ca rac3 rock2 thbs1 verify
Tagcloud (Intersection) ?		myosin