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GRIN1 and PRKCE
Number of citations of the paper that reports this interaction (PMID
10862698
)
203
Data Source:
HPRD
(in vivo)
GRIN1
PRKCE
Gene Name
glutamate receptor, ionotropic, N-methyl D-aspartate 1
protein kinase C, epsilon
Image
Gene Ontology Annotations
Cellular Component
Endoplasmic Reticulum
Plasma Membrane
Integral Component Of Plasma Membrane
Synaptic Vesicle
Cell Surface
Postsynaptic Density
N-methyl-D-aspartate Selective Glutamate Receptor Complex
Cell Junction
Dendrite
Dendrite Membrane
Neuron Projection
Synaptic Cleft
Terminal Bouton
Dendritic Spine
Synapse
Postsynaptic Membrane
Excitatory Synapse
Neuronal Postsynaptic Density
Nucleus
Cytoplasm
Mitochondrion
Endoplasmic Reticulum
Golgi Apparatus
Cytosol
Cytoskeleton
Plasma Membrane
Perinuclear Region Of Cytoplasm
Cell Periphery
Molecular Function
N-methyl-D-aspartate Selective Glutamate Receptor Activity
Extracellular-glutamate-gated Ion Channel Activity
Calcium Channel Activity
Calcium Ion Binding
Protein Binding
Calmodulin Binding
Glycine Binding
Glutamate Binding
Enzyme Binding
Voltage-gated Cation Channel Activity
Glutamate Receptor Binding
Neurotransmitter Binding
Protein Heterodimerization Activity
Actin Monomer Binding
Protein Serine/threonine Kinase Activity
Protein Kinase C Activity
Calcium-independent Protein Kinase C Activity
Signal Transducer Activity
Protein Binding
ATP Binding
Enzyme Activator Activity
Enzyme Binding
Receptor Activator Activity
Ethanol Binding
Metal Ion Binding
14-3-3 Protein Binding
Biological Process
Conditioned Taste Aversion
Suckling Behavior
Response To Amphetamine
Cation Transport
Cellular Calcium Ion Homeostasis
Synaptic Transmission
Axon Guidance
Respiratory Gaseous Exchange
Long-term Memory
Adult Locomotory Behavior
Olfactory Learning
Visual Learning
Propylene Metabolic Process
Sensory Perception Of Pain
Pons Maturation
Cerebral Cortex Development
Ion Transmembrane Transport
Regulation Of Ion Transmembrane Transport
Social Behavior
Ionotropic Glutamate Receptor Signaling Pathway
Synaptic Transmission, Glutamatergic
Regulation Of Membrane Potential
Positive Regulation Of Apoptotic Process
Response To Morphine
Negative Regulation Of Neuron Apoptotic Process
Regulation Of Respiratory Gaseous Exchange
Response To Ethanol
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Ephrin Receptor Signaling Pathway
Regulation Of Long-term Neuronal Synaptic Plasticity
Rhythmic Process
Regulation Of Dendrite Morphogenesis
Regulation Of Axonogenesis
Protein Tetramerization
Response To Calcium Ion
Regulation Of Synapse Assembly
Calcium Ion Homeostasis
Regulation Of Excitatory Postsynaptic Membrane Potential
Prepulse Inhibition
Male Mating Behavior
Response To Fungicide
Calcium Ion Transmembrane Transport
Cellular Response To Manganese Ion
Positive Regulation Of Excitatory Postsynaptic Membrane Potential
Macrophage Activation Involved In Immune Response
Protein Phosphorylation
Apoptotic Process
Cell Cycle
Cell Adhesion
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Activation Of Phospholipase C Activity
Blood Coagulation
Fibroblast Growth Factor Receptor Signaling Pathway
Positive Regulation Of Epithelial Cell Migration
Positive Regulation Of Fibroblast Migration
Positive Regulation Of Cell-substrate Adhesion
Peptidyl-serine Phosphorylation
Platelet Activation
Positive Regulation Of Actin Filament Polymerization
Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Insulin Secretion
Positive Regulation Of Synaptic Transmission, GABAergic
Positive Regulation Of Cytokinesis
Intracellular Signal Transduction
Locomotory Exploration Behavior
TRAM-dependent Toll-like Receptor 4 Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Response To Morphine
Positive Regulation Of MAPK Cascade
Innate Immune Response
Neurotrophin TRK Receptor Signaling Pathway
Regulation Of Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Lipid Catabolic Process
Release Of Sequestered Calcium Ion Into Cytosol
Cell Division
Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Positive Regulation Of Mucus Secretion
Cellular Response To Ethanol
Cellular Response To Hypoxia
Positive Regulation Of Wound Healing
Positive Regulation Of Receptor Activity
Negative Regulation Of Sodium Ion Transmembrane Transporter Activity
Positive Regulation Of Cellular Glucuronidation
Pathways
EPHB-mediated forward signaling
Axon guidance
Activation of NMDA receptor upon glutamate binding and postsynaptic events
CREB phosphorylation through the activation of CaMKII
EPH-Ephrin signaling
CREB phosphorylation through the activation of Ras
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Unblocking of NMDA receptor, glutamate binding and activation
Ras activation uopn Ca2+ infux through NMDA receptor
Post NMDA receptor activation events
Transmission across Chemical Synapses
G alpha (q) signalling events
Signaling by GPCR
Signaling by FGFR in disease
Phospholipase C-mediated cascade
Signaling by EGFRvIII in Cancer
Effects of PIP2 hydrolysis
PLCG1 events in ERBB2 signaling
DAG and IP3 signaling
DAP12 signaling
Gastrin-CREB signalling pathway via PKC and MAPK
Downstream signaling of activated FGFR
G alpha (z) signalling events
Role of phospholipids in phagocytosis
Fcgamma receptor (FCGR) dependent phagocytosis
Innate Immune System
Signaling by PDGF
DAP12 interactions
Signalling by NGF
Signaling by Ligand-Responsive EGFR Variants in Cancer
NGF signalling via TRKA from the plasma membrane
Signaling by Overexpressed Wild-Type EGFR in Cancer
Signaling by FGFR
EGFR interacts with phospholipase C-gamma
G alpha (q) signalling events
Signaling by ERBB2
Signaling by EGFR
GPCR downstream signaling
Downstream signal transduction
PLC-gamma1 signalling
Signaling by EGFR in Cancer
Platelet activation, signaling and aggregation
Drugs
L-Glutamic Acid
Meperidine
Orphenadrine
Dcka, 5,7-Dichlorokynurenic Acid
D-Serine
Cycloleucine
Milnacipran
Agmatine
Diseases
GWAS
Post-traumatic stress disorder (asjusted for relatedness) (
23726511
)
Hematocrit (
19862010
)
Hematological and biochemical traits (
20139978
)
Hemoglobin (
19862010
)
Red blood cell count (
20139978
)
Red blood cell traits (
23446634
23222517
)
Protein-Protein Interactions
53 interactors:
ACTN2
AKAP9
CALM1
CAMK2A
CAMK2G
CANX
CDH2
CIT
CLTC
CTNNB1
DLG2
DLG3
DLG4
DLGAP4
DNM1
DRD1
DUSP4
EPHB2
EPHB4
FUS
FYN
GRIN2A
GRIN2B
GRIN2D
GRIN3A
HNRNPU
HRAS
HSPA1A
INA
LNX1
LRP8
MAP2
MAP2K2
MYH9
NANOS1
NEFL
NF1
PLAT
PLCG1
PPP2R1A
PPP2R2A
PRKCA
PRKCB
PRKCE
PRKCG
RAP2A
RPS6KA3
SP3
SPTAN1
SYNGAP1
TJP1
TRAF3
TUBA4B
57 interactors:
ACTA1
ACTC1
ADAP1
AFAP1
AKAP9
ATF2
BRAF
BTK
CFTR
CHAT
CNN1
COPB1
COPB2
DSP
ELAVL1
FYN
GAD1
GAD2
GJA1
GNA12
GNA13
GNB2L1
GRIN1
GRIN2D
GRM5
HIST1H1A
HK2
IKBKB
ITGB1
ITGB2
KEAP1
KRT1
KRT18
MAP4K4
MAPK1
MAPK3
MARK2
MYH2
NANOG
NUMB
OPRD1
PDLIM5
PDPK1
PECAM1
PIK3CB
PPP1R14A
PRKD1
RAF1
RASGRP3
RPS6KB2
SLC25A4
SLC4A3
SNCA
SRC
TIAM1
TRPV1
VDAC1
Entrez ID
2902
5581
HPRD ID
15926
01500
Ensembl ID
ENSG00000176884
ENSG00000171132
Uniprot IDs
Q05586
Q59GW0
Q5VSF9
L7RTI5
Q02156
PDB IDs
2HQW
2NR1
3BYA
2WH0
Enriched GO Terms of Interacting Partners
?
Synaptic Transmission
Cell-cell Signaling
Nervous System Development
Signaling
Locomotion
Cell Communication
Neurogenesis
Cell Differentiation
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Response To Organic Substance
Generation Of Neurons
Neuron Projection Development
Neuron Development
Developmental Process
Cell Development
Neuron Differentiation
Response To External Stimulus
Signal Transduction
Cell Projection Organization
Movement Of Cell Or Subcellular Component
Enzyme Linked Receptor Protein Signaling Pathway
Multicellular Organismal Development
System Development
Cellular Response To Stimulus
Anatomical Structure Development
Axon Development
Axon Guidance
Regulation Of Synaptic Transmission
Regulation Of Synaptic Plasticity
Neuron Projection Morphogenesis
Cell Surface Receptor Signaling Pathway
Axonogenesis
Cellular Response To Organic Substance
Response To Wounding
Cell Morphogenesis Involved In Neuron Differentiation
Cell Morphogenesis Involved In Differentiation
Learning
Response To Stimulus
Regulation Of Signaling
Chemotaxis
Neurotrophin TRK Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Response To Abiotic Stimulus
Fibroblast Growth Factor Receptor Signaling Pathway
Blood Coagulation
Hemostasis
Cell Projection Morphogenesis
Single-organism Behavior
Cellular Response To Growth Factor Stimulus
Learning Or Memory
Regulation Of Cellular Component Organization
Developmental Process
Anatomical Structure Development
Apoptotic Process
Signaling
Programmed Cell Death
Cell Differentiation
Cell Communication
Cell Death
Response To Organic Substance
Death
Positive Regulation Of Protein Metabolic Process
Neurotrophin TRK Receptor Signaling Pathway
Regulation Of Body Fluid Levels
Positive Regulation Of Cellular Protein Metabolic Process
Neurotrophin Signaling Pathway
Response To Growth Factor
Response To Stimulus
Positive Regulation Of Protein Phosphorylation
Wound Healing
Multicellular Organismal Development
Cell-cell Signaling
Cellular Response To Fibroblast Growth Factor Stimulus
Platelet Activation
Cell Activation
Response To Fibroblast Growth Factor
Fc Receptor Signaling Pathway
Innate Immune Response
Cellular Response To Growth Factor Stimulus
Response To Wounding
Immune Response-regulating Signaling Pathway
Positive Regulation Of Metabolic Process
Regulation Of Phosphorylation
Synaptic Transmission
Positive Regulation Of Phosphorylation
Regulation Of Cellular Amino Acid Metabolic Process
Defense Response
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Positive Regulation Of Protein Modification Process
Regulation Of Signaling
Regulation Of Protein Phosphorylation
Fibroblast Growth Factor Receptor Signaling Pathway
Regulation Of Protein Metabolic Process
Blood Coagulation
Cell Surface Receptor Signaling Pathway
Hemostasis
Regulation Of Locomotion
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Cellular Component Movement
Movement Of Cell Or Subcellular Component
Tagcloud
?
16p11
acgh
actually
appreciating
brwd3
cnv
cnvs
comorbidity
debated
disrupt
duplication
electroclinical
epilepsies
epileptic
grin2a
inheritance
inherited
kcnc3
microdeletions
microduplications
neurodevelopmental
novo
prrt2
re
res
rolandic
shank1
speech
tspan7
Tagcloud (Difference)
?
16p11
acgh
actually
appreciating
brwd3
cnv
cnvs
comorbidity
debated
disrupt
duplication
electroclinical
epilepsies
epileptic
grin2a
inheritance
inherited
kcnc3
microdeletions
microduplications
neurodevelopmental
novo
prrt2
re
res
rolandic
shank1
speech
tspan7
Tagcloud (Intersection)
?