GRIN1 and CIT

Number of citations of the paper that reports this interaction (PMID 10862698)
203

Data Source:
HPRD (in vivo)

		GRIN1	CIT
Gene Name		glutamate receptor, ionotropic, N-methyl D-aspartate 1	citron rho-interacting serine/threonine kinase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle Cell Surface Postsynaptic Density N-methyl-D-aspartate Selective Glutamate Receptor Complex Cell Junction Dendrite Dendrite Membrane Neuron Projection Synaptic Cleft Terminal Bouton Dendritic Spine Synapse Postsynaptic Membrane Excitatory Synapse Neuronal Postsynaptic Density	Ruffle Vacuole Plasma Membrane Actin Cytoskeleton Membrane Golgi Cisterna Neuronal Cell Body
	Molecular Function	N-methyl-D-aspartate Selective Glutamate Receptor Activity Extracellular-glutamate-gated Ion Channel Activity Calcium Channel Activity Calcium Ion Binding Protein Binding Calmodulin Binding Glycine Binding Glutamate Binding Enzyme Binding Voltage-gated Cation Channel Activity Glutamate Receptor Binding Neurotransmitter Binding Protein Heterodimerization Activity	Protein Serine/threonine Kinase Activity Small GTPase Regulator Activity Protein Binding ATP Binding Rho GTPase Binding SH3 Domain Binding PDZ Domain Binding Metal Ion Binding
	Biological Process	Conditioned Taste Aversion Suckling Behavior Response To Amphetamine Cation Transport Cellular Calcium Ion Homeostasis Synaptic Transmission Axon Guidance Respiratory Gaseous Exchange Long-term Memory Adult Locomotory Behavior Olfactory Learning Visual Learning Propylene Metabolic Process Sensory Perception Of Pain Pons Maturation Cerebral Cortex Development Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Social Behavior Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Membrane Potential Positive Regulation Of Apoptotic Process Response To Morphine Negative Regulation Of Neuron Apoptotic Process Regulation Of Respiratory Gaseous Exchange Response To Ethanol Positive Regulation Of Transcription From RNA Polymerase II Promoter Ephrin Receptor Signaling Pathway Regulation Of Long-term Neuronal Synaptic Plasticity Rhythmic Process Regulation Of Dendrite Morphogenesis Regulation Of Axonogenesis Protein Tetramerization Response To Calcium Ion Regulation Of Synapse Assembly Calcium Ion Homeostasis Regulation Of Excitatory Postsynaptic Membrane Potential Prepulse Inhibition Male Mating Behavior Response To Fungicide Calcium Ion Transmembrane Transport Cellular Response To Manganese Ion Positive Regulation Of Excitatory Postsynaptic Membrane Potential	Mitotic Sister Chromatid Segregation G2/M Transition Of Mitotic Cell Cycle Cytokinesis Protein Phosphorylation Golgi Organization Mitotic Nuclear Division Metaphase/anaphase Transition Of Mitotic Cell Cycle Spermatogenesis Regulation Of Actin Polymerization Or Depolymerization Dendrite Development Positive Regulation Of Cytokinesis Intracellular Signal Transduction Generation Of Neurons Negative Regulation Of Dendrite Morphogenesis Regulation Of Catalytic Activity
Pathways		EPHB-mediated forward signaling Axon guidance Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII EPH-Ephrin signaling CREB phosphorylation through the activation of Ras Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Unblocking of NMDA receptor, glutamate binding and activation Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses
Drugs		L-Glutamic Acid Meperidine Orphenadrine Dcka, 5,7-Dichlorokynurenic Acid D-Serine Cycloleucine Milnacipran Agmatine
Diseases
GWAS		Post-traumatic stress disorder (asjusted for relatedness) ( 23726511)
Protein-Protein Interactions		53 interactors: ACTN2 AKAP9 CALM1 CAMK2A CAMK2G CANX CDH2 CIT CLTC CTNNB1 DLG2 DLG3 DLG4 DLGAP4 DNM1 DRD1 DUSP4 EPHB2 EPHB4 FUS FYN GRIN2A GRIN2B GRIN2D GRIN3A HNRNPU HRAS HSPA1A INA LNX1 LRP8 MAP2 MAP2K2 MYH9 NANOS1 NEFL NF1 PLAT PLCG1 PPP2R1A PPP2R2A PRKCA PRKCB PRKCE PRKCG RAP2A RPS6KA3 SP3 SPTAN1 SYNGAP1 TJP1 TRAF3 TUBA4B	9 interactors: DISC1 DLG4 GRIN1 GRIN2D RAC1 RHOA RHOB RHOC RND3
Entrez ID		2902	11113
HPRD ID		15926	09289
Ensembl ID		ENSG00000176884	ENSG00000122966
Uniprot IDs		Q05586 Q59GW0 Q5VSF9	O14578
PDB IDs		2HQW 2NR1 3BYA
Enriched GO Terms of Interacting Partners?		Synaptic Transmission Cell-cell Signaling Nervous System Development Signaling Locomotion Cell Communication Neurogenesis Cell Differentiation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Organic Substance Generation Of Neurons Neuron Projection Development Neuron Development Developmental Process Cell Development Neuron Differentiation Response To External Stimulus Signal Transduction Cell Projection Organization Movement Of Cell Or Subcellular Component Enzyme Linked Receptor Protein Signaling Pathway Multicellular Organismal Development System Development Cellular Response To Stimulus Anatomical Structure Development Axon Development Axon Guidance Regulation Of Synaptic Transmission Regulation Of Synaptic Plasticity Neuron Projection Morphogenesis Cell Surface Receptor Signaling Pathway Axonogenesis Cellular Response To Organic Substance Response To Wounding Cell Morphogenesis Involved In Neuron Differentiation Cell Morphogenesis Involved In Differentiation Learning Response To Stimulus Regulation Of Signaling Chemotaxis Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Response To Abiotic Stimulus Fibroblast Growth Factor Receptor Signaling Pathway Blood Coagulation Hemostasis Cell Projection Morphogenesis Single-organism Behavior Cellular Response To Growth Factor Stimulus Learning Or Memory	Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Locomotion Cell Morphogenesis Involved In Differentiation Skeletal Muscle Satellite Cell Migration Neuron Projection Development Movement Of Cell Or Subcellular Component Cell Projection Morphogenesis Generation Of Neurons Cell Part Morphogenesis Neurogenesis Neuron Development Response To External Stimulus Cell Morphogenesis Neuron Differentiation Cell Projection Organization Small GTPase Mediated Signal Transduction Signal Transduction Nervous System Development Signaling Cell Communication Regulation Of Small GTPase Mediated Signal Transduction Ephrin Receptor Signaling Pathway Cytokinesis Cellular Response To Stimulus Neuromuscular Process Cell Development Intracellular Signal Transduction Regulation Of Signaling Regulation Of Cell Projection Organization Negative Regulation Of Receptor-mediated Endocytosis Cerebral Cortex Development Cytoskeleton Organization Cell Differentiation Platelet Activation Wound Healing Startle Response Actin Cytoskeleton Organization Pallium Development Cell-cell Junction Organization Regulation Of Long-term Neuronal Synaptic Plasticity Actin Filament-based Process Positive Regulation Of Excitatory Postsynaptic Membrane Potential Anatomical Structure Morphogenesis Response To Stimulus Locomotory Behavior
Tagcloud ?			ag allograft atn bdr black bloc cadaver cold declining drop en fatality flush hematocrit immunosuppression kidneys lrd match mismatch okt3 pra predispose preservation procurement prompted recipient rejection uw yr
Tagcloud (Difference) ?			ag allograft atn bdr black bloc cadaver cold declining drop en fatality flush hematocrit immunosuppression kidneys lrd match mismatch okt3 pra predispose preservation procurement prompted recipient rejection uw yr
Tagcloud (Intersection) ?