MYH9 and ATG9B

Number of citations of the paper that reports this interaction (PubMedID 34131310)
28

Data Source:
BioGRID (pull down)

		MYH9	ATG9B
Description		myosin heavy chain 9	autophagy related 9B
Image
GO Annotations	Cellular Component	Stress Fiber Ruffle Immunological Synapse Uropod Nucleus Cytoplasm Golgi Apparatus Spindle Actomyosin Contractile Ring Cytosol Cytoskeleton Plasma Membrane Brush Border Adherens Junction Focal Adhesion Cell Cortex COP9 Signalosome Cytoplasmic Side Of Plasma Membrane Cell Surface Actin Cytoskeleton Membrane Myosin Complex Myosin II Complex Nuclear Body Cortical Cytoskeleton Cell Leading Edge Cytoplasmic Vesicle Neuromuscular Junction Cleavage Furrow Myosin Filament Protein-containing Complex Actomyosin Cortical Granule Extracellular Exosome Myosin II Filament Supramolecular Fiber	Golgi Membrane Phagophore Assembly Site Cytoplasm Autophagosome Endoplasmic Reticulum Membrane Trans-Golgi Network Membrane Phagophore Assembly Site Membrane Recycling Endosome Membrane
	Molecular Function	Microfilament Motor Activity Nucleotide Binding Virus Receptor Activity RNA Binding Cytoskeletal Motor Activity Actin Binding Integrin Binding Protein Binding Calmodulin Binding ATP Binding Protein Domain Specific Binding Identical Protein Binding Protein Homodimerization Activity Protein-membrane Adaptor Activity ADP Binding Cadherin Binding Actin Filament Binding	Protein Binding Phospholipid Scramblase Activity
	Biological Process	Meiotic Spindle Organization Cell Morphogenesis Angiogenesis In Utero Embryonic Development Establishment Of T Cell Polarity Plasma Membrane Repair Membrane Protein Ectodomain Proteolysis Phagocytosis, Engulfment Cytoskeleton Organization Cell Adhesion Integrin-mediated Signaling Pathway Myoblast Fusion Regulation Of Cell Shape Protein Transport Actin Cytoskeleton Organization Actin Filament-based Movement Platelet Formation Monocyte Differentiation Actomyosin Structure Organization Lysosome Localization Cytokinetic Process Uropod Organization Regulation Of Actin Filament-based Process Endodermal Cell Differentiation Blood Vessel Endothelial Cell Migration Regulated Exocytosis Symbiont Entry Into Host Cell Cell Motility Leukocyte Migration Establishment Of Meiotic Spindle Localization Cytoplasmic Actin-based Contraction Involved In Cell Motility Cortical Granule Exocytosis Platelet Aggregation Cell-cell Adhesion Negative Regulation Of Actin Filament Severing Positive Regulation Of Protein Processing In Phagocytic Vesicle Regulation Of Plasma Membrane Repair	Autophagosome Assembly Mitophagy Lipid Transport Autophagy Plasma Membrane Phospholipid Scrambling Protein Localization To Phagophore Assembly Site Piecemeal Microautophagy Of The Nucleus Bone Morphogenesis Reticulophagy Programmed Necrotic Cell Death
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Regulation of actin dynamics for phagocytic cup formation EPHA-mediated growth cone collapse Sema4D induced cell migration and growth-cone collapse RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea CD163 mediating an anti-inflammatory response FCGR3A-mediated phagocytosis Signaling by ALK fusions and activated point mutants	Macroautophagy
Drugs		Artenimol
Diseases		MYH9-related kidney diseases, including: Epstein syndrome; Fechtner syndrome Macrothrombocytopenia; May-Hegglin anomaly; Sebastian syndrome; Fechtner syndrome; Epstein syndrome Deafness, autosomal dominant
GWAS		Diabetic kidney disease ( 26305897) End-stage renal disease (non-diabetic) ( 20532800) Glomerulosclerosis ( 20668430) Heel bone mineral density ( 30598549) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference ( 30108283) Language performance in older adults (adjusted for episodic memory) ( 28577822) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Optic nerve measurement (rim area) ( 20395239) Platelet count ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Eyebrow thickness ( 26926045) Femur bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		31 interacting genes: ANXA1 ASCC2 ATG9B CASP4 CBL CD163 CSNK2A1 CXCR4 DUX4 FXR1 GRIN1 MEN1 MTDH MYBPC3 MYH10 MYL9 MYOM1 MYOM2 NUDCD2 OVGP1 PPP2CA PTPN6 RAC1 RNF10 S100A4 SNCA TTN TUFM UBE2I WEE2-AS1 YWHAZ	3 interacting genes: HOXA1 MYH9 OTX1
Entrez ID		4627	285973
HPRD ID		01177	08253
Ensembl ID		ENSG00000100345	ENSG00000181652
Uniprot IDs		P35579	Q674R7
PDB IDs		2LNK 3ZWH 4CFQ 4CFR 4ETO	8POE
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Muscle Myosin Filament Actomyosin Structure Organization M Band Actin Cytoskeleton Organization Actin Filament-based Process Sarcomere Organization Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Skeletal Muscle Organ Development Cytoplasm Striated Muscle Myosin Thick Filament Positive Regulation Of Signal Transduction Myofibril Assembly Extraocular Skeletal Muscle Development Cytosol Organelle Organization Myosin Heavy Chain Binding Calcium Ion Binding Positive Regulation Of Transport Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Cellular Component Assembly Membraneless Organelle Assembly Positive Regulation Of Protein Secretion Supramolecular Fiber Intracellular Signal Transduction Positive Regulation Of Secretion By Cell Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Kinase A Signaling Regulation Of Microtubule Polymerization Positive Regulation Of Secretion Cytoskeleton Organization Cell Cortex Regulation Of Transport Cardiac Myofibril Assembly Inflammatory Response Regulation Of Hydrogen Peroxide Metabolic Process Regulation Of Secretion By Cell Regulation Of Intracellular Signal Transduction Regulation Of Synaptic Plasticity Glutamatergic Synapse Actin Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Vesicle Fusion Regulation Of Secretion Regulation Of Microtubule Polymerization Or Depolymerization	Semicircular Canal Formation Abducens Nerve Formation Optokinetic Behavior Uropod Organization Cortical Granule Exocytosis Negative Regulation Of Actin Filament Severing Positive Regulation Of Protein Processing In Phagocytic Vesicle Diencephalon Morphogenesis Myosin II Filament Metencephalon Development Anatomical Structure Morphogenesis Actomyosin Contractile Ring Cortical Granule Cytoplasmic Actin-based Contraction Involved In Cell Motility DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Outer Ear Morphogenesis Embryonic Morphogenesis Embryonic Neurocranium Morphogenesis Actomyosin Regulation Of Plasma Membrane Repair Establishment Of Meiotic Spindle Localization Supramolecular Fiber Establishment Of T Cell Polarity Uropod Regulation Of Plasma Membrane Organization Positive Regulation Of Macromolecule Biosynthetic Process Sequence-specific Double-stranded DNA Binding Monocyte Differentiation DNA-binding Transcription Factor Activity Positive Regulation Of Biosynthetic Process Cochlea Morphogenesis Positive Regulation Of Macromolecule Metabolic Process Anatomical Structure Formation Involved In Morphogenesis Cochlea Development Plasma Membrane Repair Myoblast Fusion Calcium-ion Regulated Exocytosis Microfilament Motor Activity COP9 Signalosome Cortical Cytoskeleton Blood Vessel Endothelial Cell Migration Cell-cell Fusion Membrane Protein Ectodomain Proteolysis Platelet Formation Actin-mediated Cell Contraction Positive Regulation Of Protein Processing ADP Binding Endodermal Cell Differentiation Meiotic Spindle Organization Syncytium Formation
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