MYH9 and CASP4

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		MYH9	CASP4
Description		myosin heavy chain 9	caspase 4
Image
GO Annotations	Cellular Component	Stress Fiber Ruffle Immunological Synapse Uropod Nucleus Cytoplasm Golgi Apparatus Spindle Actomyosin Contractile Ring Cytosol Cytoskeleton Plasma Membrane Brush Border Adherens Junction Focal Adhesion Cell Cortex COP9 Signalosome Cytoplasmic Side Of Plasma Membrane Cell Surface Actin Cytoskeleton Membrane Myosin Complex Myosin II Complex Nuclear Body Cortical Cytoskeleton Cell Leading Edge Cytoplasmic Vesicle Neuromuscular Junction Cleavage Furrow Myosin Filament Protein-containing Complex Actomyosin Cortical Granule Extracellular Exosome Myosin II Filament Supramolecular Fiber	Extracellular Region Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Protein-containing Complex Canonical Inflammasome Complex NLRP1 Inflammasome Complex Non-canonical Inflammasome Complex
	Molecular Function	Microfilament Motor Activity Nucleotide Binding Virus Receptor Activity RNA Binding Cytoskeletal Motor Activity Actin Binding Integrin Binding Protein Binding Calmodulin Binding ATP Binding Protein Domain Specific Binding Identical Protein Binding Protein Homodimerization Activity Protein-membrane Adaptor Activity ADP Binding Cadherin Binding Actin Filament Binding	Lipopolysaccharide Binding Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Lipid Binding Hydrolase Activity CARD Domain Binding
	Biological Process	Meiotic Spindle Organization Cell Morphogenesis Angiogenesis In Utero Embryonic Development Establishment Of T Cell Polarity Plasma Membrane Repair Membrane Protein Ectodomain Proteolysis Phagocytosis, Engulfment Cytoskeleton Organization Cell Adhesion Integrin-mediated Signaling Pathway Myoblast Fusion Regulation Of Cell Shape Protein Transport Actin Cytoskeleton Organization Actin Filament-based Movement Platelet Formation Monocyte Differentiation Actomyosin Structure Organization Lysosome Localization Cytokinetic Process Uropod Organization Regulation Of Actin Filament-based Process Endodermal Cell Differentiation Blood Vessel Endothelial Cell Migration Regulated Exocytosis Symbiont Entry Into Host Cell Cell Motility Leukocyte Migration Establishment Of Meiotic Spindle Localization Cytoplasmic Actin-based Contraction Involved In Cell Motility Cortical Granule Exocytosis Platelet Aggregation Cell-cell Adhesion Negative Regulation Of Actin Filament Severing Positive Regulation Of Protein Processing In Phagocytic Vesicle Regulation Of Plasma Membrane Repair	Immune System Process Proteolysis Apoptotic Process Inflammatory Response Protein Secretion Programmed Cell Death Protein Autoprocessing Interleukin-18-mediated Signaling Pathway Defense Response To Bacterium Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process NLRP3 Inflammasome Complex Assembly Innate Immune Response Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Defense Response To Gram-positive Bacterium Protein Maturation Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Pyroptotic Inflammatory Response Intrinsic Apoptotic Signaling Pathway Pyroptotic Cell Death Non-canonical Inflammasome Complex Assembly Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Amyloid-beta Positive Regulation Of Interleukin-18-mediated Signaling Pathway
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Regulation of actin dynamics for phagocytic cup formation EPHA-mediated growth cone collapse Sema4D induced cell migration and growth-cone collapse RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea CD163 mediating an anti-inflammatory response FCGR3A-mediated phagocytosis Signaling by ALK fusions and activated point mutants	NOD1/2 Signaling Pathway Pyroptosis CASP4 inflammasome assembly Microbial factors inhibit CASP4 activity CASP4-mediated substrate cleavage
Drugs		Artenimol	Incadronic acid
Diseases		MYH9-related kidney diseases, including: Epstein syndrome; Fechtner syndrome Macrothrombocytopenia; May-Hegglin anomaly; Sebastian syndrome; Fechtner syndrome; Epstein syndrome Deafness, autosomal dominant
GWAS		Diabetic kidney disease ( 26305897) End-stage renal disease (non-diabetic) ( 20532800) Glomerulosclerosis ( 20668430) Heel bone mineral density ( 30598549) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference ( 30108283) Language performance in older adults (adjusted for episodic memory) ( 28577822) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Optic nerve measurement (rim area) ( 20395239) Platelet count ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Major depressive disorder ( 29317602)
Interacting Genes		31 interacting genes: ANXA1 ASCC2 ATG9B CASP4 CBL CD163 CSNK2A1 CXCR4 DUX4 FXR1 GRIN1 MEN1 MTDH MYBPC3 MYH10 MYL9 MYOM1 MYOM2 NUDCD2 OVGP1 PPP2CA PTPN6 RAC1 RNF10 S100A4 SNCA TTN TUFM UBE2I WEE2-AS1 YWHAZ	16 interacting genes: APAF1 APP CASP10 CASP14 CASP3 CASP8 DSP ELF4 IL18 IL1B IL37 MYH9 NOD1 PLA2G4A PSEN1 SERPINB9
Entrez ID		4627	837
HPRD ID		01177	04047
Ensembl ID		ENSG00000100345	ENSG00000196954
Uniprot IDs		P35579	P49662
PDB IDs		2LNK 3ZWH 4CFQ 4CFR 4ETO	6KMZ 6NRY 7WR0 7WR1 7WR4 7WR5 7WR6 8J6K 8SPB
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Muscle Myosin Filament Actomyosin Structure Organization M Band Actin Cytoskeleton Organization Actin Filament-based Process Sarcomere Organization Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Skeletal Muscle Organ Development Cytoplasm Striated Muscle Myosin Thick Filament Positive Regulation Of Signal Transduction Myofibril Assembly Extraocular Skeletal Muscle Development Cytosol Organelle Organization Myosin Heavy Chain Binding Calcium Ion Binding Positive Regulation Of Transport Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Cellular Component Assembly Membraneless Organelle Assembly Positive Regulation Of Protein Secretion Supramolecular Fiber Intracellular Signal Transduction Positive Regulation Of Secretion By Cell Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Kinase A Signaling Regulation Of Microtubule Polymerization Positive Regulation Of Secretion Cytoskeleton Organization Cell Cortex Regulation Of Transport Cardiac Myofibril Assembly Inflammatory Response Regulation Of Hydrogen Peroxide Metabolic Process Regulation Of Secretion By Cell Regulation Of Intracellular Signal Transduction Regulation Of Synaptic Plasticity Glutamatergic Synapse Actin Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Vesicle Fusion Regulation Of Secretion Regulation Of Microtubule Polymerization Or Depolymerization	Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Regulation Of Defense Response Positive Regulation Of Neuron Apoptotic Process Regulation Of Cytokine Production Cell Death Programmed Cell Death Regulation Of Inflammatory Response Regulation Of Neuron Apoptotic Process Regulation Of Apoptotic Process Immune System Process Regulation Of Programmed Cell Death Regulation Of Interleukin-6 Production Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Cysteine-type Endopeptidase Activity Positive Regulation Of Inflammatory Response Regulation Of Tumor Necrosis Factor Production Astrocyte Activation Positive Regulation Of T-helper 1 Type Immune Response Apoptotic Process Regulation Of Proteolysis Positive Regulation Of Proteolysis Regulation Of Immune Response Execution Phase Of Apoptosis Regulation Of Interleukin-1 Beta Production Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Defense Response Regulation Of Interleukin-1 Production Defense Response To Gram-positive Bacterium Astrocyte Activation Involved In Immune Response Death Effector Domain Binding Regulation Of Immune System Process Positive Regulation Of Cytokine Production Positive Regulation Of Protein Metabolic Process Cysteine-type Peptidase Activity Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Response To Lipopolysaccharide Inflammatory Response Apoptotic Signaling Pathway Response To Anesthetic Response To Molecule Of Bacterial Origin Ripoptosome CD95 Death-inducing Signaling Complex Regulation Of Multicellular Organismal Process Death-inducing Signaling Complex Natural Killer Cell Activation Positive Regulation Of T-helper 1 Cell Cytokine Production Cell Activation Positive Regulation Of Immune System Process
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