GRIN1 and GRIN3A

Number of citations of the paper that reports this interaction (PMID 9620802)
79

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		GRIN1	GRIN3A
Gene Name		glutamate receptor, ionotropic, N-methyl D-aspartate 1	glutamate receptor, ionotropic, N-methyl-D-aspartate 3A
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle Cell Surface Postsynaptic Density N-methyl-D-aspartate Selective Glutamate Receptor Complex Cell Junction Dendrite Dendrite Membrane Neuron Projection Synaptic Cleft Terminal Bouton Dendritic Spine Synapse Postsynaptic Membrane Excitatory Synapse Neuronal Postsynaptic Density	Postsynaptic Density Membrane Integral Component Of Membrane N-methyl-D-aspartate Selective Glutamate Receptor Complex Cell Junction Dendrite Neuron Projection Neuronal Cell Body Synapse Postsynaptic Membrane
	Molecular Function	N-methyl-D-aspartate Selective Glutamate Receptor Activity Extracellular-glutamate-gated Ion Channel Activity Calcium Channel Activity Calcium Ion Binding Protein Binding Calmodulin Binding Glycine Binding Glutamate Binding Enzyme Binding Voltage-gated Cation Channel Activity Glutamate Receptor Binding Neurotransmitter Binding Protein Heterodimerization Activity	N-methyl-D-aspartate Selective Glutamate Receptor Activity Extracellular-glutamate-gated Ion Channel Activity Calcium Channel Activity Protein Binding Glycine Binding Neurotransmitter Binding Identical Protein Binding Protein Phosphatase 2A Binding
	Biological Process	Conditioned Taste Aversion Suckling Behavior Response To Amphetamine Cation Transport Cellular Calcium Ion Homeostasis Synaptic Transmission Axon Guidance Respiratory Gaseous Exchange Long-term Memory Adult Locomotory Behavior Olfactory Learning Visual Learning Propylene Metabolic Process Sensory Perception Of Pain Pons Maturation Cerebral Cortex Development Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Social Behavior Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Membrane Potential Positive Regulation Of Apoptotic Process Response To Morphine Negative Regulation Of Neuron Apoptotic Process Regulation Of Respiratory Gaseous Exchange Response To Ethanol Positive Regulation Of Transcription From RNA Polymerase II Promoter Ephrin Receptor Signaling Pathway Regulation Of Long-term Neuronal Synaptic Plasticity Rhythmic Process Regulation Of Dendrite Morphogenesis Regulation Of Axonogenesis Protein Tetramerization Response To Calcium Ion Regulation Of Synapse Assembly Calcium Ion Homeostasis Regulation Of Excitatory Postsynaptic Membrane Potential Prepulse Inhibition Male Mating Behavior Response To Fungicide Calcium Ion Transmembrane Transport Cellular Response To Manganese Ion Positive Regulation Of Excitatory Postsynaptic Membrane Potential	Calcium Ion Transport Dendrite Development Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Response To Ethanol Rhythmic Process Prepulse Inhibition Calcium Ion Transmembrane Transport
Pathways		EPHB-mediated forward signaling Axon guidance Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII EPH-Ephrin signaling CREB phosphorylation through the activation of Ras Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Unblocking of NMDA receptor, glutamate binding and activation Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses
Drugs		L-Glutamic Acid Meperidine Orphenadrine Dcka, 5,7-Dichlorokynurenic Acid D-Serine Cycloleucine Milnacipran Agmatine	L-Glutamic Acid Tramadol Methadone Ethopropazine Dextromethorphan Acamprosate Procaine Ethanol Amantadine Felbamate Memantine Halothane Chloroprocaine Orphenadrine Ketamine Tenocyclidine Rolicyclidine Phencyclidine
Diseases
GWAS		Post-traumatic stress disorder (asjusted for relatedness) ( 23726511)	Obesity-related traits ( 23251661) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Protein-Protein Interactions		53 interactors: ACTN2 AKAP9 CALM1 CAMK2A CAMK2G CANX CDH2 CIT CLTC CTNNB1 DLG2 DLG3 DLG4 DLGAP4 DNM1 DRD1 DUSP4 EPHB2 EPHB4 FUS FYN GRIN2A GRIN2B GRIN2D GRIN3A HNRNPU HRAS HSPA1A INA LNX1 LRP8 MAP2 MAP2K2 MYH9 NANOS1 NEFL NF1 PLAT PLCG1 PPP2R1A PPP2R2A PRKCA PRKCB PRKCE PRKCG RAP2A RPS6KA3 SP3 SPTAN1 SYNGAP1 TJP1 TRAF3 TUBA4B	5 interactors: DLG4 DYNLL1 GRIN1 GRIN2A GRIN2B
Entrez ID		2902	116443
HPRD ID		15926	09443
Ensembl ID		ENSG00000176884	ENSG00000198785
Uniprot IDs		Q05586 Q59GW0 Q5VSF9	Q8TCU5
PDB IDs		2HQW 2NR1 3BYA
Enriched GO Terms of Interacting Partners?		Synaptic Transmission Cell-cell Signaling Nervous System Development Signaling Locomotion Cell Communication Neurogenesis Cell Differentiation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Organic Substance Generation Of Neurons Neuron Projection Development Neuron Development Developmental Process Cell Development Neuron Differentiation Response To External Stimulus Signal Transduction Cell Projection Organization Movement Of Cell Or Subcellular Component Enzyme Linked Receptor Protein Signaling Pathway Multicellular Organismal Development System Development Cellular Response To Stimulus Anatomical Structure Development Axon Development Axon Guidance Regulation Of Synaptic Transmission Regulation Of Synaptic Plasticity Neuron Projection Morphogenesis Cell Surface Receptor Signaling Pathway Axonogenesis Cellular Response To Organic Substance Response To Wounding Cell Morphogenesis Involved In Neuron Differentiation Cell Morphogenesis Involved In Differentiation Learning Response To Stimulus Regulation Of Signaling Chemotaxis Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Response To Abiotic Stimulus Fibroblast Growth Factor Receptor Signaling Pathway Blood Coagulation Hemostasis Cell Projection Morphogenesis Single-organism Behavior Cellular Response To Growth Factor Stimulus Learning Or Memory	Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Membrane Depolarization Neuromuscular Process Learning Regulation Of Synaptic Plasticity Startle Response Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Learning Or Memory Regulation Of Membrane Potential Cognition Regulation Of Synaptic Transmission Glutamate Receptor Signaling Pathway Neuron-neuron Synaptic Transmission Sensory Perception Of Pain Single-organism Behavior Memory Synaptic Transmission Behavior Response To Ethanol Calcium Ion Transmembrane Transport Suckling Behavior Nervous System Development Cell-cell Signaling Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Excitatory Postsynaptic Membrane Potential Response To Amphetamine Calcium Ion Transport Social Behavior Neurological System Process Positive Regulation Of Membrane Potential Locomotion Regulation Of Signaling Axon Guidance Response To Amine Regulation Of Neuronal Synaptic Plasticity Visual Learning Visual Behavior Axonogenesis Neurogenesis Associative Learning Axon Development Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Chemotaxis Ephrin Receptor Signaling Pathway Response To External Stimulus Feeding Behavior
Tagcloud ?			a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh dnm1 drd2 eas fagerstrom gabbr2 mstcc n549s nrxn1 nrxn2 nrxn3 ntrk2 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss
Tagcloud (Difference) ?			a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh dnm1 drd2 eas fagerstrom gabbr2 mstcc n549s nrxn1 nrxn2 nrxn3 ntrk2 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss
Tagcloud (Intersection) ?