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GRIN1 and MAP2K2
Number of citations of the paper that reports this interaction (PMID
10862698
)
203
Data Source:
HPRD
(in vivo)
GRIN1
MAP2K2
Gene Name
glutamate receptor, ionotropic, N-methyl D-aspartate 1
mitogen-activated protein kinase kinase 2
Image
Gene Ontology Annotations
Cellular Component
Endoplasmic Reticulum
Plasma Membrane
Integral Component Of Plasma Membrane
Synaptic Vesicle
Cell Surface
Postsynaptic Density
N-methyl-D-aspartate Selective Glutamate Receptor Complex
Cell Junction
Dendrite
Dendrite Membrane
Neuron Projection
Synaptic Cleft
Terminal Bouton
Dendritic Spine
Synapse
Postsynaptic Membrane
Excitatory Synapse
Neuronal Postsynaptic Density
Extracellular Region
Nucleus
Cytoplasm
Mitochondrion
Early Endosome
Late Endosome
Peroxisomal Membrane
Endoplasmic Reticulum
Golgi Apparatus
Cytosol
Microtubule
Cell-cell Junction
Focal Adhesion
Cell Cortex
Cytoplasmic Side Of Plasma Membrane
Perinuclear Region Of Cytoplasm
Molecular Function
N-methyl-D-aspartate Selective Glutamate Receptor Activity
Extracellular-glutamate-gated Ion Channel Activity
Calcium Channel Activity
Calcium Ion Binding
Protein Binding
Calmodulin Binding
Glycine Binding
Glutamate Binding
Enzyme Binding
Voltage-gated Cation Channel Activity
Glutamate Receptor Binding
Neurotransmitter Binding
Protein Heterodimerization Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
PDZ Domain Binding
Protein Complex Scaffold
Protein Serine/threonine Kinase Activator Activity
Scaffold Protein Binding
Biological Process
Conditioned Taste Aversion
Suckling Behavior
Response To Amphetamine
Cation Transport
Cellular Calcium Ion Homeostasis
Synaptic Transmission
Axon Guidance
Respiratory Gaseous Exchange
Long-term Memory
Adult Locomotory Behavior
Olfactory Learning
Visual Learning
Propylene Metabolic Process
Sensory Perception Of Pain
Pons Maturation
Cerebral Cortex Development
Ion Transmembrane Transport
Regulation Of Ion Transmembrane Transport
Social Behavior
Ionotropic Glutamate Receptor Signaling Pathway
Synaptic Transmission, Glutamatergic
Regulation Of Membrane Potential
Positive Regulation Of Apoptotic Process
Response To Morphine
Negative Regulation Of Neuron Apoptotic Process
Regulation Of Respiratory Gaseous Exchange
Response To Ethanol
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Ephrin Receptor Signaling Pathway
Regulation Of Long-term Neuronal Synaptic Plasticity
Rhythmic Process
Regulation Of Dendrite Morphogenesis
Regulation Of Axonogenesis
Protein Tetramerization
Response To Calcium Ion
Regulation Of Synapse Assembly
Calcium Ion Homeostasis
Regulation Of Excitatory Postsynaptic Membrane Potential
Prepulse Inhibition
Male Mating Behavior
Response To Fungicide
Calcium Ion Transmembrane Transport
Cellular Response To Manganese Ion
Positive Regulation Of Excitatory Postsynaptic Membrane Potential
MAPK Cascade
Activation Of MAPKK Activity
Activation Of MAPK Activity
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Small GTPase Mediated Signal Transduction
Ras Protein Signal Transduction
Axon Guidance
Insulin Receptor Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Pathogenesis
Peptidyl-tyrosine Phosphorylation
Regulation Of Stress-activated MAPK Cascade
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Peptidyl-serine Autophosphorylation
Fc-epsilon Receptor Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Innate Immune Response
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Stress-activated MAPK Cascade
ERK1 And ERK2 Cascade
Positive Regulation Of Protein Serine/threonine Kinase Activity
Regulation Of Golgi Inheritance
Positive Regulation Of Cell Motility
Regulation Of Early Endosome To Late Endosome Transport
Pathways
EPHB-mediated forward signaling
Axon guidance
Activation of NMDA receptor upon glutamate binding and postsynaptic events
CREB phosphorylation through the activation of CaMKII
EPH-Ephrin signaling
CREB phosphorylation through the activation of Ras
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Unblocking of NMDA receptor, glutamate binding and activation
Ras activation uopn Ca2+ infux through NMDA receptor
Post NMDA receptor activation events
Transmission across Chemical Synapses
Signaling by GPCR
Signaling by FGFR in disease
MEK activation
FCERI mediated MAPK activation
Signaling by EGFRvIII in Cancer
Signaling by SCF-KIT
SHC1 events in ERBB2 signaling
Toll Like Receptor TLR1:TLR2 Cascade
DAP12 signaling
Uptake and actions of bacterial toxins
Toll Like Receptor 5 (TLR5) Cascade
Gastrin-CREB signalling pathway via PKC and MAPK
MyD88 dependent cascade initiated on endosome
Toll Like Receptor 9 (TLR9) Cascade
SOS-mediated signalling
Uptake and function of anthrax toxins
SHC-mediated signalling
Signaling by PDGF
DAP12 interactions
TRIF-mediated TLR3/TLR4 signaling
SHC-related events triggered by IGF1R
GRB2 events in EGFR signaling
Signaling by ERBB4
Toll Like Receptor 2 (TLR2) Cascade
Signaling by ERBB2
Signaling by EGFR
Signaling by Interleukins
SHC1 events in ERBB4 signaling
Signaling by VEGF
Toll Like Receptor 3 (TLR3) Cascade
Toll Like Receptor 4 (TLR4) Cascade
Signalling to RAS
Downstream signal transduction
Fc epsilon receptor (FCERI) signaling
Signaling by EGFR in Cancer
Interleukin-2 signaling
Frs2-mediated activation
Signaling by Leptin
Signalling to ERKs
Prolonged ERK activation events
ERK activation
Axon guidance
IRS-mediated signalling
Toll Like Receptor 7/8 (TLR7/8) Cascade
L1CAM interactions
IGF1R signaling cascade
Toll Like Receptor TLR6:TLR2 Cascade
VEGFA-VEGFR2 Pathway
Activated TLR4 signalling
IRS-related events triggered by IGF1R
MyD88 cascade initiated on plasma membrane
VEGFR2 mediated cell proliferation
GRB2 events in ERBB2 signaling
ERK activation
RAF phosphorylates MEK
Downstream signaling of activated FGFR
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88:Mal cascade initiated on plasma membrane
NCAM signaling for neurite out-growth
RAF/MAP kinase cascade
Signalling to p38 via RIT and RIN
Signaling by Insulin receptor
Innate Immune System
Signalling by NGF
Signal transduction by L1
Insulin receptor signalling cascade
SOS-mediated signalling
MAP kinase activation in TLR cascade
SHC-mediated signalling
Cytokine Signaling in Immune system
IRS-related events
Signaling by Ligand-Responsive EGFR Variants in Cancer
NGF signalling via TRKA from the plasma membrane
SHC-related events
MyD88-independent cascade
Signaling by Overexpressed Wild-Type EGFR in Cancer
ERK2 activation
Signaling by FGFR
ARMS-mediated activation
Toll-Like Receptors Cascades
Toll Like Receptor 10 (TLR10) Cascade
SHC1 events in EGFR signaling
IRS-mediated signalling
FRS2-mediated cascade
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
ERK2 activation
Drugs
L-Glutamic Acid
Meperidine
Orphenadrine
Dcka, 5,7-Dichlorokynurenic Acid
D-Serine
Cycloleucine
Milnacipran
Agmatine
Diseases
GWAS
Post-traumatic stress disorder (asjusted for relatedness) (
23726511
)
Protein-Protein Interactions
53 interactors:
ACTN2
AKAP9
CALM1
CAMK2A
CAMK2G
CANX
CDH2
CIT
CLTC
CTNNB1
DLG2
DLG3
DLG4
DLGAP4
DNM1
DRD1
DUSP4
EPHB2
EPHB4
FUS
FYN
GRIN2A
GRIN2B
GRIN2D
GRIN3A
HNRNPU
HRAS
HSPA1A
INA
LNX1
LRP8
MAP2
MAP2K2
MYH9
NANOS1
NEFL
NF1
PLAT
PLCG1
PPP2R1A
PPP2R2A
PRKCA
PRKCB
PRKCE
PRKCG
RAP2A
RPS6KA3
SP3
SPTAN1
SYNGAP1
TJP1
TRAF3
TUBA4B
18 interactors:
ARAF
BRAF
CASP9
CCNDBP1
CNKSR1
COPS5
DUSP3
FAM65B
GRIN1
GRIN2D
LAMTOR3
LIG4
MAPK1
MAPK3
MAPK8
RAF1
RGS12
ZNF207
Entrez ID
2902
5605
HPRD ID
15926
03164
Ensembl ID
ENSG00000176884
ENSG00000126934
Uniprot IDs
Q05586
Q59GW0
Q5VSF9
B3KS97
P36507
PDB IDs
2HQW
2NR1
3BYA
1S9I
4H3Q
Enriched GO Terms of Interacting Partners
?
Synaptic Transmission
Cell-cell Signaling
Nervous System Development
Signaling
Locomotion
Cell Communication
Neurogenesis
Cell Differentiation
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Response To Organic Substance
Generation Of Neurons
Neuron Projection Development
Neuron Development
Developmental Process
Cell Development
Neuron Differentiation
Response To External Stimulus
Signal Transduction
Cell Projection Organization
Movement Of Cell Or Subcellular Component
Enzyme Linked Receptor Protein Signaling Pathway
Multicellular Organismal Development
System Development
Cellular Response To Stimulus
Anatomical Structure Development
Axon Development
Axon Guidance
Regulation Of Synaptic Transmission
Regulation Of Synaptic Plasticity
Neuron Projection Morphogenesis
Cell Surface Receptor Signaling Pathway
Axonogenesis
Cellular Response To Organic Substance
Response To Wounding
Cell Morphogenesis Involved In Neuron Differentiation
Cell Morphogenesis Involved In Differentiation
Learning
Response To Stimulus
Regulation Of Signaling
Chemotaxis
Neurotrophin TRK Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Response To Abiotic Stimulus
Fibroblast Growth Factor Receptor Signaling Pathway
Blood Coagulation
Hemostasis
Cell Projection Morphogenesis
Single-organism Behavior
Cellular Response To Growth Factor Stimulus
Learning Or Memory
Neurotrophin TRK Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
MAPK Cascade
Signal Transduction By Phosphorylation
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Cellular Response To Growth Factor Stimulus
Fibroblast Growth Factor Receptor Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Response To Growth Factor
Activation Of MAPKK Activity
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Intracellular Signal Transduction
MyD88-dependent Toll-like Receptor Signaling Pathway
Cellular Response To Fibroblast Growth Factor Stimulus
Response To Fibroblast Growth Factor
Toll-like Receptor 4 Signaling Pathway
Response To Abiotic Stimulus
Fc-epsilon Receptor Signaling Pathway
Immune Response-regulating Signaling Pathway
Toll-like Receptor Signaling Pathway
Fc Receptor Signaling Pathway
Stress-activated MAPK Cascade
Stress-activated Protein Kinase Signaling Cascade
Regulation Of Signaling
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Regulation Of Golgi Inheritance
Response To Metal Ion
Cellular Response To Inorganic Substance
Activation Of Innate Immune Response
Regulation Of Cellular Protein Metabolic Process
Regulation Of MAPK Cascade
Caveolin-mediated Endocytosis
Positive Regulation Of Metabolic Process
Epidermal Growth Factor Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
ERBB Signaling Pathway
Positive Regulation Of Catalytic Activity
Regulation Of Signal Transduction
Regulation Of Cellular Amino Acid Metabolic Process
Positive Regulation Of Innate Immune Response
Regulation Of Protein Metabolic Process
Tagcloud
?
acclimatized
adra1d
altitude
araf
argef11
arhgap24
ascent
cardiogenic
circuitry
cldn23
cldn6
ece1
ednra
genic
hape
inciting
mapk10
mylk
oxphos
pak3
pathoetiology
plcb1
pxn
skew
sos1
unacclimatized
vasoconstriction
vcam1
Tagcloud (Difference)
?
acclimatized
adra1d
altitude
araf
argef11
arhgap24
ascent
cardiogenic
circuitry
cldn23
cldn6
ece1
ednra
genic
hape
inciting
mapk10
mylk
oxphos
pak3
pathoetiology
plcb1
pxn
skew
sos1
unacclimatized
vasoconstriction
vcam1
Tagcloud (Intersection)
?