GRIN1 and DLGAP4

Number of citations of the paper that reports this interaction (PMID 10862698)
203

Data Source:
HPRD (in vivo)

		GRIN1	DLGAP4
Gene Name		glutamate receptor, ionotropic, N-methyl D-aspartate 1	discs, large (Drosophila) homolog-associated protein 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle Cell Surface Postsynaptic Density N-methyl-D-aspartate Selective Glutamate Receptor Complex Cell Junction Dendrite Dendrite Membrane Neuron Projection Synaptic Cleft Terminal Bouton Dendritic Spine Synapse Postsynaptic Membrane Excitatory Synapse Neuronal Postsynaptic Density	Membrane Synapse
	Molecular Function	N-methyl-D-aspartate Selective Glutamate Receptor Activity Extracellular-glutamate-gated Ion Channel Activity Calcium Channel Activity Calcium Ion Binding Protein Binding Calmodulin Binding Glycine Binding Glutamate Binding Enzyme Binding Voltage-gated Cation Channel Activity Glutamate Receptor Binding Neurotransmitter Binding Protein Heterodimerization Activity	Protein Binding
	Biological Process	Conditioned Taste Aversion Suckling Behavior Response To Amphetamine Cation Transport Cellular Calcium Ion Homeostasis Synaptic Transmission Axon Guidance Respiratory Gaseous Exchange Long-term Memory Adult Locomotory Behavior Olfactory Learning Visual Learning Propylene Metabolic Process Sensory Perception Of Pain Pons Maturation Cerebral Cortex Development Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Social Behavior Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Membrane Potential Positive Regulation Of Apoptotic Process Response To Morphine Negative Regulation Of Neuron Apoptotic Process Regulation Of Respiratory Gaseous Exchange Response To Ethanol Positive Regulation Of Transcription From RNA Polymerase II Promoter Ephrin Receptor Signaling Pathway Regulation Of Long-term Neuronal Synaptic Plasticity Rhythmic Process Regulation Of Dendrite Morphogenesis Regulation Of Axonogenesis Protein Tetramerization Response To Calcium Ion Regulation Of Synapse Assembly Calcium Ion Homeostasis Regulation Of Excitatory Postsynaptic Membrane Potential Prepulse Inhibition Male Mating Behavior Response To Fungicide Calcium Ion Transmembrane Transport Cellular Response To Manganese Ion Positive Regulation Of Excitatory Postsynaptic Membrane Potential	Cell-cell Signaling
Pathways		EPHB-mediated forward signaling Axon guidance Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII EPH-Ephrin signaling CREB phosphorylation through the activation of Ras Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Unblocking of NMDA receptor, glutamate binding and activation Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses
Drugs		L-Glutamic Acid Meperidine Orphenadrine Dcka, 5,7-Dichlorokynurenic Acid D-Serine Cycloleucine Milnacipran Agmatine
Diseases
GWAS		Post-traumatic stress disorder (asjusted for relatedness) ( 23726511)
Protein-Protein Interactions		53 interactors: ACTN2 AKAP9 CALM1 CAMK2A CAMK2G CANX CDH2 CIT CLTC CTNNB1 DLG2 DLG3 DLG4 DLGAP4 DNM1 DRD1 DUSP4 EPHB2 EPHB4 FUS FYN GRIN2A GRIN2B GRIN2D GRIN3A HNRNPU HRAS HSPA1A INA LNX1 LRP8 MAP2 MAP2K2 MYH9 NANOS1 NEFL NF1 PLAT PLCG1 PPP2R1A PPP2R2A PRKCA PRKCB PRKCE PRKCG RAP2A RPS6KA3 SP3 SPTAN1 SYNGAP1 TJP1 TRAF3 TUBA4B	15 interactors: BIN1 DLG1 DLG3 DLG4 EXOC4 GRIN1 GRIN2D PLP2 PPP1R1B SH3GL2 SHANK2 SHANK3 SORBS2 SYNGAP1 UBC
Entrez ID		2902	22839
HPRD ID		15926	16826
Ensembl ID		ENSG00000176884	ENSG00000080845
Uniprot IDs		Q05586 Q59GW0 Q5VSF9	Q9Y2H0
PDB IDs		2HQW 2NR1 3BYA
Enriched GO Terms of Interacting Partners?		Synaptic Transmission Cell-cell Signaling Nervous System Development Signaling Locomotion Cell Communication Neurogenesis Cell Differentiation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Organic Substance Generation Of Neurons Neuron Projection Development Neuron Development Developmental Process Cell Development Neuron Differentiation Response To External Stimulus Signal Transduction Cell Projection Organization Movement Of Cell Or Subcellular Component Enzyme Linked Receptor Protein Signaling Pathway Multicellular Organismal Development System Development Cellular Response To Stimulus Anatomical Structure Development Axon Development Axon Guidance Regulation Of Synaptic Transmission Regulation Of Synaptic Plasticity Neuron Projection Morphogenesis Cell Surface Receptor Signaling Pathway Axonogenesis Cellular Response To Organic Substance Response To Wounding Cell Morphogenesis Involved In Neuron Differentiation Cell Morphogenesis Involved In Differentiation Learning Response To Stimulus Regulation Of Signaling Chemotaxis Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Response To Abiotic Stimulus Fibroblast Growth Factor Receptor Signaling Pathway Blood Coagulation Hemostasis Cell Projection Morphogenesis Single-organism Behavior Cellular Response To Growth Factor Stimulus Learning Or Memory	Receptor Clustering Learning Regulation Of Long-term Neuronal Synaptic Plasticity Single-organism Behavior Social Behavior Learning Or Memory Receptor Localization To Synapse Membrane Organization Cognition Synaptic Transmission Behavior Regulation Of Neuronal Synaptic Plasticity Regulation Of Synaptic Plasticity Vocalization Behavior Protein Localization To Synapse Neuron Projection Development Cell-cell Signaling Establishment Or Maintenance Of Apical/basal Cell Polarity Neuron Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Synaptic Transmission Positive Regulation Of Excitatory Postsynaptic Membrane Potential Chemotaxis Generation Of Neurons Neuron Projection Morphogenesis Nervous System Development Protein Localization To Membrane Positive Regulation Of Membrane Potential Neurogenesis Neuron Differentiation Cell Projection Organization Neurological System Process Cell Morphogenesis Involved In Differentiation Axon Guidance Adult Behavior Response To External Stimulus Locomotion Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Nucleotide Phosphorylation Cell Projection Morphogenesis Visual Learning Cell Part Morphogenesis Visual Behavior Regulation Of Excitatory Postsynaptic Membrane Potential Axonogenesis Regulation Of Postsynaptic Membrane Potential Synapse Assembly Axon Development Associative Learning Regulation Of Membrane Potential
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