GRIN1 and CAMK2G

Number of citations: 64 (PubMedID 9670010)
Data Source: BioGRID (enzymatic study)

		GRIN1	CAMK2G
Name		glutamate ionotropic receptor NMDA type subunit 1	calcium/calmodulin dependent protein kinase II gamma
Structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Plasma Membrane Synaptic Vesicle Cell Surface Postsynaptic Density Membrane NMDA Selective Glutamate Receptor Complex Dendrite Monoatomic Ion Channel Complex Neuron Projection Synaptic Cleft Terminal Bouton Dendritic Spine Synapse Postsynaptic Membrane Excitatory Synapse Synaptic Membrane Postsynaptic Density Membrane Neurotransmitter Receptor Complex	Nucleoplasm Cytoplasm Cytosol Calcium- And Calmodulin-dependent Protein Kinase Complex Postsynaptic Density Membrane Sarcoplasmic Reticulum Endocytic Vesicle Membrane Sarcoplasmic Reticulum Membrane Neuron Projection
	Molecular Function	Amyloid-beta Binding NMDA Glutamate Receptor Activity Monoatomic Ion Channel Activity Calcium Channel Activity Calcium Ion Binding Protein Binding Calmodulin Binding Ligand-gated Monoatomic Ion Channel Activity Ligand-gated Sodium Channel Activity Glycine Binding Glutamate Binding Glutamate-gated Calcium Ion Channel Activity Signaling Receptor Activity Protein-containing Complex Binding Metal Ion Binding Glycine-gated Cation Channel Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Calcium-dependent Protein Serine/threonine Phosphatase Activity Protein Binding Calmodulin Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Homodimerization Activity Protein Serine Kinase Activity
	Biological Process	Monoatomic Ion Transport Monoatomic Cation Transport Chemical Synaptic Transmission Brain Development Visual Learning Positive Regulation Of Calcium Ion Transport Into Cytosol Propylene Metabolic Process Calcium-mediated Signaling Monoatomic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Sodium Ion Transmembrane Transport Regulation Of Membrane Potential Response To Ethanol Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Protein Heterotetramerization Positive Regulation Of Synaptic Transmission, Glutamatergic Calcium Ion Homeostasis Excitatory Postsynaptic Potential Calcium Ion Transmembrane Transport Calcium Ion Transmembrane Import Into Cytosol Monoatomic Cation Transmembrane Transport Excitatory Chemical Synaptic Transmission Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Monoatomic Cation Transmembrane Transport Cellular Response To Amyloid-beta Response To Glycine Positive Regulation Of Excitatory Postsynaptic Potential	Nervous System Development Regulation Of Neuron Projection Development Regulation Of Skeletal Muscle Adaptation Insulin Secretion Cell Differentiation Regulation Of Neuronal Synaptic Plasticity Regulation Of Calcium Ion Transport Long-term Synaptic Potentiation Regulation Of Protein Localization To Plasma Membrane
Pathways		EPHB-mediated forward signaling EPHB-mediated forward signaling Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation	CaMK IV-mediated phosphorylation of CREB HSF1-dependent transactivation Trafficking of AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Ras activation upon Ca2+ influx through NMDA receptor Phase 0 - rapid depolarisation Ion homeostasis RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Interferon gamma signaling Regulation of MECP2 expression and activity Ion transport by P-type ATPases Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs		Glutamic acid Tramadol Enflurane Atomoxetine Pentobarbital Methadone Secobarbital Meperidine Dextropropoxyphene Acamprosate Donepezil Guaifenesin Memantine Memantine Orphenadrine Phenobarbital Aripiprazole Prasterone 5,7-Dichlorokynurenic acid D-Serine Cycloleucine Milnacipran CNS-5161 Acetylcysteine Ketobemidone Gavestinel Agmatine Ifenprodil Magnesium acetate tetrahydrate Magnesium carbonate Esketamine Fluciclovine (18F)	Bosutinib 1-tert-butyl-3-(3-methylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Fostamatinib
GWAS		Post-traumatic stress disorder (asjusted for relatedness) ( 23726511 )	Body size at age 10 ( 32376654 ) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143 ) Crohn's disease ( 28067908 ) FEV1 ( 30804560 ) Itch intensity from mosquito bite adjusted by bite size ( 28199695 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Lung function (FEV1/FVC) ( 30804560 ) Lung function (FVC) ( 30804560 ) Multiple sclerosis ( 31604244 ) Paclitaxel disposition in epithelial ovarian cancer ( 29367611 ) Peak expiratory flow ( 30804560 ) Psoriasis ( 25939698 ) Psoriasis vulgaris ( 26626624 ) Systemic lupus erythematosus ( 28714469 ) Type 2 diabetes ( 30054458 )
Interacting Genes		58 interacting genes: ACTN2 AKAP9 APP BDKRB1 CALM1 CAMK2A CAMK2G CANX CDH2 CIT CLTC CTNNB1 DLG1 DLG2 DLG3 DLG4 DLGAP4 DNM1 DRD1 DUSP4 EPHB2 EPHB4 FUS FYN GRIN2A GRIN2B GRIN2D GRIN3A HNRNPU HRAS HSPA1A INA LNX1 LRP8 MAP2 MAP2K2 MYH9 NANOS1 NEFL NF1 NR1H4 PLAT PLCG1 PPP2R1A PPP2R2A PRKCA PRKCB PRKCE PRKCG PTAFR RAP2A RPS6KA3 SP3 SPTAN1 SYNGAP1 TJP1 TRAF3 TUBA4B	51 interacting genes: ACTN2 ACTN4 ADCY3 ATF1 CABP2 CALM1 CDC37 CEBPA CHAT CREM DUS1L EGFR ESRRG FLNA FXR1 FXR2 GRIA1 GRIA4 GRIN1 GRIN2B KANK2 KRTAP19-3 KRTAP6-1 KRTAP6-3 LRRC7 MAP3K7 MRPL11 MYLK NUTF2 NXF1 PEA15 PLCB3 PSMB1 PTEN RCHY1 RRAD RYR1 SMAD2 SMAD3 SMAD4 SPR STAT1 STMN1 STRBP SYN1 TH TIAM1 TNPO2 TNPO3 TTC5 UBE2I
Entrez ID		2902	818
HPRD ID		15926	03672
Ensembl ID		ENSG00000176884	ENSG00000148660
Uniprot IDs		Q05586 Q59GW0 Q5VSF9	A0A2Q3DQE3 B3KY86 H0Y6G2 Q13280 Q13555 Q5SWX3
PDB IDs		2HQW 2NR1 3BYA 5H8F 5H8H 5H8N 5H8Q 5I2K 5I2N 5KCJ 5KDT 5TP9 5TPA 6IRA 6IRF 6IRG 6IRH 7EOQ 7EOR 7EOS 7EOT 7EOU 7EU7 7EU8 7YFF 7YFL 7YFM 7YFO 7YFR 8E92 8E93 8E94 8E96 8E97 8E98 8E99 8JIZ 8JJ0 8JJ1 8JJ2 8UUE 8VUL 8VUN 8VUQ 8VUR 8VUS 8VUT 8VUU 8VUV 8Y1V 9D37 9D38 9D39 9D3A 9D3B 9D3C 9GIB 9GIC 9GID 9GIE 9GIF 9GIG 9GJ1	2UX0 2V7O
GO Terms Enriched among Interactors		Modulation Of Chemical Synaptic Transmission Glutamatergic Synapse Regulation Of Neuronal Synaptic Plasticity Regulation Of Biological Quality Regulation Of Synaptic Plasticity Trans-synaptic Signaling Synaptic Signaling Positive Regulation Of Synaptic Transmission Chemical Synaptic Transmission Regulation Of Cellular Component Organization Long-term Synaptic Potentiation Neuron Projection Synapse Signaling Postsynaptic Density Membrane Cell Communication Regulation Of Monoatomic Ion Transport Regulation Of Cell Communication Regulation Of Signaling Cell-cell Signaling Regulation Of Transport Synaptic Membrane Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Anatomical Structure Morphogenesis Regulation Of Synapse Organization Glutamate Receptor Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Signal Transduction Plasma Membrane Postsynaptic Density Regulation Of Metal Ion Transport Regulation Of Cellular Localization Learning Or Memory Cell Projection Protein Kinase Binding Regulation Of Apoptotic Process Cell Junction Organization NMDA Glutamate Receptor Activity Regulation Of Calcium Ion Transport Dendrite Ligand-gated Ion Channel Signaling Pathway Regulation Of Protein Localization Developmental Process Regulation Of Protein Localization To Membrane Regulation Of Programmed Cell Death Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cognition	Intracellular Signaling Cassette Intracellular Signal Transduction Cytoplasm Synapse Cytosol Neuron Projection SMAD Protein Complex Identical Protein Binding Learning Or Memory Modulation Of Chemical Synaptic Transmission Glutamate-gated Calcium Ion Channel Activity Ionotropic Glutamate Receptor Signaling Pathway Heteromeric SMAD Protein Complex Positive Regulation Of Excitatory Postsynaptic Potential Ligand-gated Monoatomic Ion Channel Activity Cognition Chemical Synaptic Transmission Regulation Of Membrane Potential Dendritic Spine Signal Transduction Trans-synaptic Signaling Ligand-gated Ion Channel Signaling Pathway Calcium Ion Transmembrane Import Into Cytosol Synaptic Signaling Positive Regulation Of Signal Transduction Positive Regulation Of RNA Metabolic Process Kinase Binding Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Modulation Of Excitatory Postsynaptic Potential I-SMAD Binding Postsynaptic Density Membrane Glutamate Receptor Signaling Pathway Transcription Coactivator Binding Regulation Of Monoatomic Ion Transmembrane Transport Activin Responsive Factor Complex Paraxial Mesoderm Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Calmodulin Binding Regulation Of Neuronal Synaptic Plasticity Nuclear Import Signal Receptor Activity Regulation Of Monoatomic Ion Transport Regulation Of Synaptic Plasticity Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Cell Communication Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cell Surface Receptor Signaling Pathway Cell Development Positive Regulation Of Signaling Ameboidal-type Cell Migration