GPX1 and MAPK6

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		GPX1	MAPK6
Gene Name		glutathione peroxidase 1	mitogen-activated protein kinase 6
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Extracellular Vesicular Exosome Lewy Body	Nucleus Cytoplasm
	Molecular Function	Glutathione Peroxidase Activity Selenium Binding SH3 Domain Binding Glutathione Binding Phospholipid-hydroperoxide Glutathione Peroxidase Activity	Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Heterodimerization Activity
	Biological Process	Response To Reactive Oxygen Species Temperature Homeostasis Endothelial Cell Development Negative Regulation Of Inflammatory Response To Antigenic Stimulus Purine Nucleobase Metabolic Process Purine Nucleotide Catabolic Process Triglyceride Metabolic Process Glutathione Metabolic Process Response To Lipid Hydroperoxide Aging Sensory Perception Of Sound Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Response To Xenobiotic Stimulus Response To Symbiotic Bacterium Response To Toxic Substance UV Protection Response To Glucose Response To Selenium Ion Response To Gamma Radiation Protein Oxidation Arachidonic Acid Metabolic Process Lipoxygenase Pathway Response To Estradiol Regulation Of Mammary Gland Epithelial Cell Proliferation Cellular Response To Oxidative Stress Response To Nicotine Regulation Of Gene Expression, Epigenetic Vasodilation Response To Hydrogen Peroxide Hydrogen Peroxide Catabolic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Skeletal Muscle Tissue Regeneration Regulation Of Neuron Apoptotic Process Blood Vessel Endothelial Cell Migration Small Molecule Metabolic Process Fat Cell Differentiation Cell Redox Homeostasis Skeletal Muscle Fiber Development Myoblast Proliferation Response To Folic Acid Interaction With Symbiont Positive Regulation Of Protein Kinase B Signaling Nucleobase-containing Small Molecule Metabolic Process Heart Contraction Angiogenesis Involved In Wound Healing Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Fibril Organization	MAPK Cascade Protein Phosphorylation Cell Cycle Signal Transduction
Pathways		Arachidonic acid metabolism Purine catabolism Synthesis of 5-eicosatetraenoic acids Metabolism of lipids and lipoproteins Purine metabolism Synthesis of 12-eicosatetraenoic acid derivatives Synthesis of 15-eicosatetraenoic acid derivatives Detoxification of Reactive Oxygen Species Metabolism of nucleotides
Drugs		Glutathione
Diseases
GWAS		Crohn's disease ( 21102463) Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		5 interactors: ABL1 ABL2 FAM9B MAPK6 SELENBP1	167 interactors: ACTG1 ACTR1B AMPH ANAPC5 ANK3 APBA2 APOA1 APOA1BP ARHGDIA ARPC3 ATG9A ATP5J BAG6 BARX1 BBS10 C21orf59 CA1 CA12 CALR CASP6 CCND3 CCT3 CDH13 CERS1 CFL1 CNTN1 CNTRL COPS6 CSE1L CYTH2 DBN1 DCTN2 DDOST DDR1 DGKZ DKC1 DNAJC28 DPPA4 DSCR3 DST EDF1 EEF1A2 EGLN3 EIF1 EIF3C EIF4A1 ELOF1 EMD FAM49B FBXL16 FOXO3 FXYD3 GALNT7 GATA1 GLRX3 GNB2L1 GORASP1 GPX1 HACL1 HAUS2 HDAC11 HIP1 HNRNPA0 HNRNPD HNRNPH3 HSP90AB1 HSP90B1 HSPD1 IDH3B INS ITGB3BP ITSN1 JUNB KDSR KLC1 KNSTRN LPXN MAP3K12 MAP3K7 MAPKAPK5 MASP1 MBIP MBOAT7 MCM3 MDK METTL17 METTL2A MGAT1 MIPEP MOK MON1A MTG2 MYBL2 MYOZ3 MZB1 NAT9 NDUFS6 NELFB NOL4 NRXN2 NUDT5 OSTF1 PDCD6IP PDLIM1 PHACTR3 PHC2 PHGDH PIH1D1 PLEKHM1 PLK1 PLSCR1 PPBP PPP1R7 PPP2R1A PRKAB1 PRKAR1A PRKCB PRPF38A PSAT1 PSIP1 PTPMT1 PVRL2 RAB2A RAB31 RANBP9 RAP1GAP RARA RBL1 RGS19 RPL10 RRP7A SEPT3 SEPT5 SERPINA4 SHC1 SLC20A1 SLC41A3 SMAD6 SMS SNAPC4 SNW1 SOCS3 SPG7 SPRR2D SPTAN1 SRSF5 STX7 TDP2 THAP4 TPI1 TTK TUBA1A UBA52 UBE2L3 URB1 WDR26 WDR34 WFS1 WWC1 XPO1 ZNF133 ZNF205 ZNF331 ZNF579 ZNF600 ZNF671 ZNF775
Entrez ID		2876	5597
HPRD ID		11749	04213
Ensembl ID		ENSG00000233276	ENSG00000069956
Uniprot IDs		P07203 Q7L4Q3	Q16659
PDB IDs		2F8A	2I6L
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Interferon-gamma Secretion Bergmann Glial Cell Differentiation Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Interleukin-2 Secretion Positive Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Negative Regulation Of Endothelial Cell Apoptotic Process Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Interleukin-2 Production Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Oxidoreductase Activity Regulation Of Actin Cytoskeleton Reorganization Regulation Of Extracellular Matrix Organization Astrocyte Differentiation Platelet-derived Growth Factor Receptor Signaling Pathway Cerebellum Morphogenesis Positive Regulation Of Interferon-gamma Production Hindbrain Morphogenesis Alpha-beta T Cell Differentiation Alpha-beta T Cell Activation Regulation Of Oxidoreductase Activity Neuromuscular Process Controlling Balance Regulation Of Phospholipase Activity Regulation Of Interferon-gamma Production Positive Regulation Of Cytokine Secretion Regulation Of Autophagy Cerebellum Development Transitional One Stage B Cell Differentiation Metencephalon Development Positive Regulation Of ERK1 And ERK2 Cascade Neuromuscular Process Regulation Of Cytokine Secretion Negative Regulation Of Cell-cell Adhesion Positive Regulation Of Wnt Signaling Pathway T Cell Differentiation Positive Regulation Of Cytosolic Calcium Ion Concentration Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Hindbrain Development Negative Regulation Of Phospholipase C Activity Mitochondrial Depolarization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cytosolic Calcium Ion Homeostasis Glial Cell Differentiation Regulation Of Endocytosis Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Protein Secretion Negative Regulation Of Cell Adhesion Protein Autophosphorylation Cellular Response To Dopamine	Cell Cycle Cellular Process Organelle Organization Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Mitotic Cell Cycle Cellular Metabolic Process Cell Cycle Process Gene Expression Regulation Of Metabolic Process Regulation Of Catalytic Activity Response To Organic Substance Cellular Component Assembly Regulation Of Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Metabolic Process Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cellular Metabolic Process Mitotic Cell Cycle Process Cellular Response To Organic Substance Regulation Of Gene Expression Regulation Of Cellular Component Organization Regulation Of Apoptotic Process Positive Regulation Of Transferase Activity Regulation Of Phosphorus Metabolic Process Regulation Of Immune Response Regulation Of Immune System Process Cellular Macromolecule Biosynthetic Process G2/M Transition Of Mitotic Cell Cycle Regulation Of Protein Kinase Activity Positive Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Biosynthetic Process Positive Regulation Of Protein Modification Process Regulation Of Cell Cycle Response To Wounding Negative Regulation Of Signal Transduction RNA Metabolic Process Regulation Of Cell Death Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Membrane Organization Positive Regulation Of Phosphorylation Heterocycle Metabolic Process Cell Division RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Transcription, DNA-templated
Tagcloud ?		adequately antifouling aquatic carp carpio chronically contaminants cyprinus fishes glutathione gr gsh gst gstp1 indicators juvenile lethal malondialdehyde organotin paints peroxidase pollutants recognised reductase ships tbt transferase tributyltin	astragalus barbata bcm berry bioflavonoid coptis coriolus dandelion diinodolymethane eleuthero ganoderma knotweed linteus lucidum mycelium nettle nr2f1 palmetto phellinus plau pomegranate prostacaid pumpkin pygeum sarsaparilla scutellaria sitosterolzinc skullcap stinging
Tagcloud (Difference) ?		adequately antifouling aquatic carp carpio chronically contaminants cyprinus fishes glutathione gr gsh gst gstp1 indicators juvenile lethal malondialdehyde organotin paints peroxidase pollutants recognised reductase ships tbt transferase tributyltin	astragalus barbata bcm berry bioflavonoid coptis coriolus dandelion diinodolymethane eleuthero ganoderma knotweed linteus lucidum mycelium nettle nr2f1 palmetto phellinus plau pomegranate prostacaid pumpkin pygeum sarsaparilla scutellaria sitosterolzinc skullcap stinging
Tagcloud (Intersection) ?