GPX1 and ACKR2

		GPX1	ACKR2
Description		glutathione peroxidase 1	atypical chemokine receptor 2
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Lewy Body	Nucleoplasm Endosome Early Endosome Cytosol Actin Filament Plasma Membrane External Side Of Plasma Membrane Membrane Nuclear Membrane Recycling Endosome
	Molecular Function	Peroxidase Activity Glutathione Peroxidase Activity Protein Binding Oxidoreductase Activity SH3 Domain Binding Phospholipid-hydroperoxide Glutathione Peroxidase Activity Protein Tyrosine Kinase Binding	G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding Receptor Decoy Activity
	Biological Process	Response To Reactive Oxygen Species Temperature Homeostasis Endothelial Cell Development Negative Regulation Of Inflammatory Response To Antigenic Stimulus Lipid Metabolic Process Triglyceride Metabolic Process Glutathione Metabolic Process Apoptotic Process Response To Oxidative Stress Sensory Perception Of Sound Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Response To Xenobiotic Stimulus Response To Symbiotic Bacterium Response To Wounding Response To Toxic Substance UV Protection Response To Hormone Response To Glucose Response To Selenium Ion Response To Gamma Radiation Myotube Differentiation Arachidonate Metabolic Process Lipoxygenase Pathway Response To Estradiol Response To Lipopolysaccharide Response To Hydroperoxide Response To Vitamin E Regulation Of Mammary Gland Epithelial Cell Proliferation Cellular Response To Oxidative Stress Response To Nicotine Epigenetic Regulation Of Gene Expression Vasodilation Response To Hydrogen Peroxide Hydrogen Peroxide Catabolic Process Skeletal Muscle Tissue Regeneration Blood Vessel Endothelial Cell Migration Fat Cell Differentiation Myoblast Differentiation Cell Redox Homeostasis Fibroblast Proliferation Skeletal Muscle Fiber Development Neuron Apoptotic Process Myoblast Proliferation Response To Folic Acid Biological Process Involved In Interaction With Symbiont Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Heart Contraction Angiogenesis Involved In Wound Healing Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Glucose Stimulus Negative Regulation Of Release Of Cytochrome C From Mitochondria Cellular Oxidant Detoxification Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Supramolecular Fiber Organization	Chemotaxis Inflammatory Response Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Intracellular Signal Transduction Cell Chemotaxis Chemokine-mediated Signaling Pathway
Pathways		Synthesis of 5-eicosatetraenoic acids Synthesis of 12-eicosatetraenoic acid derivatives Synthesis of 15-eicosatetraenoic acid derivatives Detoxification of Reactive Oxygen Species	Chemokine receptors bind chemokines
Drugs		Glutathione Glutathione Glutathione disulfide Cannabidiol Benzoyl peroxide Medical Cannabis Nabiximols
Diseases		Anemia due to disorders of glutathione metabolism, including: Glucose-6-phosphate dehydrogenase (G6PD) deficiency; Glutathione peroxidase (GPX) deficiency; Gamma-glutamylcysteine synthetase (GCLC) deficiency; Glutathione synthetase (GSS) deficiency
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908 21102463) Extremely high intelligence ( 29520040) Hemoglobin levels ( 32327693) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 23128233 28067908) Intelligence (MTAG) ( 29326435) Mood instability ( 31168069) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908 25082827)	Eosinophil count ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Eotaxin levels ( 27989323) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Lymphocyte percentage of white cells ( 27863252 32888494) Monocyte chemoattractant protein-1 levels ( 27989323) Monocyte count ( 27863252 32888494 29403010) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Neutrophil count ( 32888494 27863252) Neutrophil percentage of granulocytes ( 27863252) Sum basophil neutrophil counts ( 27863252) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Thymus and reactivation regulated chemokine levels ( 33227023) White blood cell count ( 27863252 32888494)
Interacting Genes		6 interacting genes: ABL1 ABL2 CFTR FAM9B MAPK6 SELENBP1	25 interacting genes: APP CCL11 CCL13 CCL14 CCL19 CCL2 CCL21 CCL25 CCL27 CCL28 CCL3 CCL3L3 CCL4 CCL5 CCL7 CCL8 CREB3 EFNA5 GJA8 MS4A1 NIPAL4 SACM1L SLC13A4 SNCA TMEM167B
Entrez ID		2876	1238
HPRD ID		11749	09095
Ensembl ID		ENSG00000233276	ENSG00000144648
Uniprot IDs		A0A2R8Y6B6 P07203 Q7L4Q3	O00590
PDB IDs		2F8A	8GO9 8J8V 8J8Z
Enriched GO Terms of Interacting Partners?		Positive Regulation Of T Cell Migration Positive Regulation Of Establishment Of T Cell Polarity Regulation Of Establishment Of T Cell Polarity Positive Regulation Of Lymphocyte Migration Regulation Of T Cell Migration Enzyme Binding Regulation Of Vasoconstriction Regulation Of Lymphocyte Migration Enzyme Activator Activity Cellular Response To Lipid Positive Regulation Of Mononuclear Cell Migration Odontogenesis Regulation Of Modification Of Synaptic Structure Positive Regulation Of Lymphocyte Activation Regulation Of Establishment Of Cell Polarity Actin Monomer Binding Protein Tyrosine Kinase Activity Synaptonemal Complex Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Vessel Diameter Maintenance Regulation Of Osteoblast Proliferation Mismatch Repair Cell-substrate Adhesion Regulation Of Tube Size Regulation Of Establishment Or Maintenance Of Cell Polarity Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Migration Positive Regulation Of Vasoconstriction Positive Regulation Of Cell Activation Nucleotide Binding Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Cellular Response To Lipopolysaccharide Response To Lipid Magnesium Ion Binding Cellular Response To Molecule Of Bacterial Origin Cellular Response To Oxygen-containing Compound Phosphotyrosine Residue Binding Substrate Adhesion-dependent Cell Spreading Protein Localization To Cytoplasmic Microtubule Plus-end Positive Regulation Of Developmental Process Immune System Process Non-membrane Spanning Protein Tyrosine Kinase Activity Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Mitotic Cleavage Furrow Formation Prostaglandin Production Involved In Inflammatory Response Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment	Chemokine Activity CCR Chemokine Receptor Binding Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Eosinophil Chemotaxis Chemotaxis Eosinophil Migration Locomotion Antimicrobial Humoral Response Humoral Immune Response Granulocyte Chemotaxis Chemokine-mediated Signaling Pathway Granulocyte Migration Cell Chemotaxis Cytokine Activity Myeloid Leukocyte Migration Leukocyte Chemotaxis Regulation Of Leukocyte Migration Leukocyte Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Response To External Biotic Stimulus Positive Regulation Of Locomotion Positive Regulation Of Leukocyte Migration Inflammatory Response Regulation Of Locomotion Cell Migration Chemokine Receptor Binding Response To Other Organism Defense Response To Symbiont Defense Response To Other Organism Regulation Of Cell Migration Regulation Of Cell Motility Cytokine-mediated Signaling Pathway Positive Regulation Of Leukocyte Chemotaxis Cell Motility Positive Regulation Of Mononuclear Cell Migration CCR1 Chemokine Receptor Binding Regulation Of Lymphocyte Migration Immune Response Extracellular Space Positive Regulation Of Lymphocyte Migration Positive Regulation Of Chemotaxis Regulation Of Mononuclear Cell Migration Immune System Process Regulation Of Lymphocyte Chemotaxis G Protein-coupled Receptor Signaling Pathway Killing Of Cells Of Another Organism Defense Response Positive Regulation Of Natural Killer Cell Chemotaxis Regulation Of Chemotaxis
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