GPX1 and FAM9B

Number of citations of the paper that reports this interaction (PMID 24722188)
1

Data Source:
BioGRID (two hybrid)

		GPX1	FAM9B
Gene Name		glutathione peroxidase 1	family with sequence similarity 9, member B
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Extracellular Vesicular Exosome Lewy Body	Nucleoplasm
	Molecular Function	Glutathione Peroxidase Activity Selenium Binding SH3 Domain Binding Glutathione Binding Phospholipid-hydroperoxide Glutathione Peroxidase Activity
	Biological Process	Response To Reactive Oxygen Species Temperature Homeostasis Endothelial Cell Development Negative Regulation Of Inflammatory Response To Antigenic Stimulus Purine Nucleobase Metabolic Process Purine Nucleotide Catabolic Process Triglyceride Metabolic Process Glutathione Metabolic Process Response To Lipid Hydroperoxide Aging Sensory Perception Of Sound Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Response To Xenobiotic Stimulus Response To Symbiotic Bacterium Response To Toxic Substance UV Protection Response To Glucose Response To Selenium Ion Response To Gamma Radiation Protein Oxidation Arachidonic Acid Metabolic Process Lipoxygenase Pathway Response To Estradiol Regulation Of Mammary Gland Epithelial Cell Proliferation Cellular Response To Oxidative Stress Response To Nicotine Regulation Of Gene Expression, Epigenetic Vasodilation Response To Hydrogen Peroxide Hydrogen Peroxide Catabolic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Skeletal Muscle Tissue Regeneration Regulation Of Neuron Apoptotic Process Blood Vessel Endothelial Cell Migration Small Molecule Metabolic Process Fat Cell Differentiation Cell Redox Homeostasis Skeletal Muscle Fiber Development Myoblast Proliferation Response To Folic Acid Interaction With Symbiont Positive Regulation Of Protein Kinase B Signaling Nucleobase-containing Small Molecule Metabolic Process Heart Contraction Angiogenesis Involved In Wound Healing Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Fibril Organization
Pathways		Arachidonic acid metabolism Purine catabolism Synthesis of 5-eicosatetraenoic acids Metabolism of lipids and lipoproteins Purine metabolism Synthesis of 12-eicosatetraenoic acid derivatives Synthesis of 15-eicosatetraenoic acid derivatives Detoxification of Reactive Oxygen Species Metabolism of nucleotides
Drugs		Glutathione
Diseases
GWAS		Crohn's disease ( 21102463) Inflammatory bowel disease ( 23128233)	Androgen levels ( 22936694)
Protein-Protein Interactions		5 interactors: ABL1 ABL2 FAM9B MAPK6 SELENBP1	118 interactors: ABT1 ACP6 ANKRD36B AP1M1 ASB6 ATF7 AURKAIP1 BAG6 BARD1 BCL2A1 BET1 BLOC1S2 BYSL C12orf10 C14orf105 C16orf72 C19orf57 C20orf195 C8orf33 CADPS CCDC106 CCDC116 CCDC70 CDC23 CDC42EP4 CDCA7L CENPL CEP57L1 CEP95 CHRAC1 CLCN1 CMTM6 COL20A1 CSDE1 CWF19L2 DAPK2 DAXX DENND2D DNAJC15 DNAJC4 EBNA1BP2 ECH1 EIF3G FAM161A FASTKD3 FCHSD2 FERD3L GFOD1 GOPC GPX1 GSTK1 ISCU LIN7A LNX1 LOC728175 LYRM2 MAB21L3 MFAP1 MOB1A MORF4L1 MORF4L2 MRPL10 MRPL28 MRPL9 MYO15B NDE1 NDUFB10 NEBL NOL4 PAGE1 PAGE3 PHYH PIN4 POLL PPP1R18 PRPF3 PSMD14 PTRH1 RAB17 RAD51B RBM17 RBM23 RMND1 RPL9 RSL24D1 RUSC1 SDCBP SDCBP2 SERPINE2 SFN SLC16A3 SLPI SMN2 SNAP29 SNAP47 SNX20 STK3 SUCLA2 SYT17 TBRG4 TCEA2 TCEANC TCEB3 TGFBI TRMT61B TSG101 TUFM TXN2 UBE2E2 URB1-AS1 XRCC4 YARS2 ZCCHC10 ZGPAT ZNF41 ZNF410 ZNF567 ZNF614
Entrez ID		2876	171483
HPRD ID		11749	15955
Ensembl ID		ENSG00000233276	ENSG00000177138
Uniprot IDs		P07203 Q7L4Q3	Q8IZU0 Q8N7Z8
PDB IDs		2F8A
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Interferon-gamma Secretion Bergmann Glial Cell Differentiation Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Interleukin-2 Secretion Positive Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Negative Regulation Of Endothelial Cell Apoptotic Process Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Interleukin-2 Production Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Oxidoreductase Activity Regulation Of Actin Cytoskeleton Reorganization Regulation Of Extracellular Matrix Organization Astrocyte Differentiation Platelet-derived Growth Factor Receptor Signaling Pathway Cerebellum Morphogenesis Positive Regulation Of Interferon-gamma Production Hindbrain Morphogenesis Alpha-beta T Cell Differentiation Alpha-beta T Cell Activation Regulation Of Oxidoreductase Activity Neuromuscular Process Controlling Balance Regulation Of Phospholipase Activity Regulation Of Interferon-gamma Production Positive Regulation Of Cytokine Secretion Regulation Of Autophagy Cerebellum Development Transitional One Stage B Cell Differentiation Metencephalon Development Positive Regulation Of ERK1 And ERK2 Cascade Neuromuscular Process Regulation Of Cytokine Secretion Negative Regulation Of Cell-cell Adhesion Positive Regulation Of Wnt Signaling Pathway T Cell Differentiation Positive Regulation Of Cytosolic Calcium Ion Concentration Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Hindbrain Development Negative Regulation Of Phospholipase C Activity Mitochondrial Depolarization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cytosolic Calcium Ion Homeostasis Glial Cell Differentiation Regulation Of Endocytosis Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Protein Secretion Negative Regulation Of Cell Adhesion Protein Autophosphorylation Cellular Response To Dopamine	Mitochondrial Translation Organelle Organization Translational Elongation Vesicle Organization Gene Expression Mitochondrion Organization Synaptic Vesicle Priming Mitochondrial Translational Elongation Translation Establishment Of Vesicle Localization Vesicle Localization Ribonucleoprotein Complex Biogenesis Establishment Of Organelle Localization Cellular Component Assembly Cellular Metabolic Process Synaptic Vesicle Transport Mitochondrial Translational Initiation Mitochondrial Translational Termination Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Extracellular Vesicular Exosome Assembly Cellular Macromolecular Complex Assembly Organelle Localization Translational Termination RNA Metabolic Process Translational Initiation Cellular Response To Stress Apoptotic Signaling Pathway Cellular Response To DNA Damage Stimulus Membrane Organization Protein Polyubiquitination Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Synaptic Vesicle Fusion To Presynaptic Membrane Cellular Process Cellular Protein Complex Disassembly Intrinsic Apoptotic Signaling Pathway Ribosome Biogenesis Neurotransmitter Secretion Macromolecule Biosynthetic Process Vesicle Fusion Pigmentation Protein Complex Disassembly Synaptic Vesicle Exocytosis Viral Process Cellular Pigmentation
Tagcloud ?		adequately antifouling aquatic carp carpio chronically contaminants cyprinus fishes glutathione gr gsh gst gstp1 indicators juvenile lethal malondialdehyde organotin paints peroxidase pollutants recognised reductase ships tbt transferase tributyltin
Tagcloud (Difference) ?		adequately antifouling aquatic carp carpio chronically contaminants cyprinus fishes glutathione gr gsh gst gstp1 indicators juvenile lethal malondialdehyde organotin paints peroxidase pollutants recognised reductase ships tbt transferase tributyltin
Tagcloud (Intersection) ?