GPX1 and ABL2

Number of citations of the paper that reports this interaction (PMID 12893824)
20

Data Source:
BioGRID (affinity chromatography technology, pull down, enzymatic study)
HPRD (in vitro)

		GPX1	ABL2
Gene Name		glutathione peroxidase 1	ABL proto-oncogene 2, non-receptor tyrosine kinase
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Extracellular Vesicular Exosome Lewy Body	Phagocytic Cup Cytosol Actin Cytoskeleton Lamellipodium Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Dendritic Spine
	Molecular Function	Glutathione Peroxidase Activity Selenium Binding SH3 Domain Binding Glutathione Binding Phospholipid-hydroperoxide Glutathione Peroxidase Activity	Magnesium Ion Binding Actin Monomer Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding Manganese Ion Binding Actin Filament Binding
	Biological Process	Response To Reactive Oxygen Species Temperature Homeostasis Endothelial Cell Development Negative Regulation Of Inflammatory Response To Antigenic Stimulus Purine Nucleobase Metabolic Process Purine Nucleotide Catabolic Process Triglyceride Metabolic Process Glutathione Metabolic Process Response To Lipid Hydroperoxide Aging Sensory Perception Of Sound Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Response To Xenobiotic Stimulus Response To Symbiotic Bacterium Response To Toxic Substance UV Protection Response To Glucose Response To Selenium Ion Response To Gamma Radiation Protein Oxidation Arachidonic Acid Metabolic Process Lipoxygenase Pathway Response To Estradiol Regulation Of Mammary Gland Epithelial Cell Proliferation Cellular Response To Oxidative Stress Response To Nicotine Regulation Of Gene Expression, Epigenetic Vasodilation Response To Hydrogen Peroxide Hydrogen Peroxide Catabolic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Skeletal Muscle Tissue Regeneration Regulation Of Neuron Apoptotic Process Blood Vessel Endothelial Cell Migration Small Molecule Metabolic Process Fat Cell Differentiation Cell Redox Homeostasis Skeletal Muscle Fiber Development Myoblast Proliferation Response To Folic Acid Interaction With Symbiont Positive Regulation Of Protein Kinase B Signaling Nucleobase-containing Small Molecule Metabolic Process Heart Contraction Angiogenesis Involved In Wound Healing Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Fibril Organization	Cellular Protein Modification Process Phagocytosis Substrate-dependent Cell Migration, Cell Extension Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Axon Guidance Visual Learning Regulation Of Autophagy Positive Regulation Of Phospholipase C Activity Positive Regulation Of Neuron Projection Development Neuron Remodeling Cell Migration Peptidyl-tyrosine Phosphorylation Cerebellum Morphogenesis Negative Regulation Of Cell-cell Adhesion Regulation Of Endocytosis Regulation Of Cell Adhesion Positive Regulation Of Protein Binding Cellular Protein Localization Negative Regulation Of Rho Protein Signal Transduction Exploration Behavior Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Alpha-beta T Cell Differentiation Platelet-derived Growth Factor Receptor Signaling Pathway Dendrite Morphogenesis Neuromuscular Process Controlling Balance Actin Filament Bundle Assembly Positive Regulation Of Oxidoreductase Activity Bergmann Glial Cell Differentiation Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Retinoic Acid Dendritic Spine Maintenance Positive Regulation Of Interleukin-2 Secretion Positive Regulation Of Interferon-gamma Secretion Regulation Of Extracellular Matrix Organization Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Cell Motility Regulation Of Actin Cytoskeleton Reorganization Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		Arachidonic acid metabolism Purine catabolism Synthesis of 5-eicosatetraenoic acids Metabolism of lipids and lipoproteins Purine metabolism Synthesis of 12-eicosatetraenoic acid derivatives Synthesis of 15-eicosatetraenoic acid derivatives Detoxification of Reactive Oxygen Species Metabolism of nucleotides	Role of Abl in Robo-Slit signaling Axon guidance Signaling by Robo receptor
Drugs		Glutathione	Adenosine triphosphate Dasatinib 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE
Diseases
GWAS		Crohn's disease ( 21102463) Inflammatory bowel disease ( 23128233)	IgE grass sensitization ( 22036096)
Protein-Protein Interactions		5 interactors: ABL1 ABL2 FAM9B MAPK6 SELENBP1	25 interactors: ABL1 BCR C15orf48 CAT CRK DOK1 EGFR EPHB2 ERBB2 ERBB3 ERBB4 FBXO38 GPX1 GRB2 HCK MAP3K10 NEDD4 NEDD4L OIP5 PSMA7 RIN1 SIVA1 SORBS2 TPD52L1 TRIP10
Entrez ID		2876	27
HPRD ID		11749	01259
Ensembl ID		ENSG00000233276	ENSG00000143322
Uniprot IDs		P07203 Q7L4Q3	P42684
PDB IDs		2F8A	2ECD 2KK1 2XYN 3GVU 3HMI 3ULR 4EIH
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Interferon-gamma Secretion Bergmann Glial Cell Differentiation Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Interleukin-2 Secretion Positive Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Negative Regulation Of Endothelial Cell Apoptotic Process Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Interleukin-2 Production Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Oxidoreductase Activity Regulation Of Actin Cytoskeleton Reorganization Regulation Of Extracellular Matrix Organization Astrocyte Differentiation Platelet-derived Growth Factor Receptor Signaling Pathway Cerebellum Morphogenesis Positive Regulation Of Interferon-gamma Production Hindbrain Morphogenesis Alpha-beta T Cell Differentiation Alpha-beta T Cell Activation Regulation Of Oxidoreductase Activity Neuromuscular Process Controlling Balance Regulation Of Phospholipase Activity Regulation Of Interferon-gamma Production Positive Regulation Of Cytokine Secretion Regulation Of Autophagy Cerebellum Development Transitional One Stage B Cell Differentiation Metencephalon Development Positive Regulation Of ERK1 And ERK2 Cascade Neuromuscular Process Regulation Of Cytokine Secretion Negative Regulation Of Cell-cell Adhesion Positive Regulation Of Wnt Signaling Pathway T Cell Differentiation Positive Regulation Of Cytosolic Calcium Ion Concentration Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Hindbrain Development Negative Regulation Of Phospholipase C Activity Mitochondrial Depolarization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cytosolic Calcium Ion Homeostasis Glial Cell Differentiation Regulation Of Endocytosis Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Protein Secretion Negative Regulation Of Cell Adhesion Protein Autophosphorylation Cellular Response To Dopamine	Regulation Of Signaling Positive Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Cell Communication Protein Autophosphorylation Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Immune Response Signaling Positive Regulation Of Protein Metabolic Process Cellular Response To Stimulus Locomotion Response To Organic Substance Immune Response-regulating Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Transferase Activity Cellular Response To Organic Substance Cellular Response To Growth Factor Stimulus Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of Cell Death Response To Growth Factor Neurotrophin Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of Protein Modification Process Peptidyl-amino Acid Modification Regulation Of Immune System Process Positive Regulation Of MAPK Cascade Cellular Protein Modification Process Regulation Of Protein Metabolic Process Phosphatidylinositol-mediated Signaling Positive Regulation Of Protein Phosphorylation Positive Regulation Of Kinase Activity Response To Stimulus Positive Regulation Of Metabolic Process Response To Stress Regulation Of Kinase Activity Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Fibroblast Growth Factor Receptor Signaling Pathway
Tagcloud ?		adequately antifouling aquatic carp carpio chronically contaminants cyprinus fishes glutathione gr gsh gst gstp1 indicators juvenile lethal malondialdehyde organotin paints peroxidase pollutants recognised reductase ships tbt transferase tributyltin	abl1 adding amenable charities crizotinib crlf2 csf1r dasatinib epor etv6 flt3 funded fusions il7r lebanese lymphoblastic ntrk3 pdgfrb ph philadelphia ptk2b rearrangements responsiveness ruxolitinib sh2b3 syrian tslp tyk2 undefined
Tagcloud (Difference) ?		adequately antifouling aquatic carp carpio chronically contaminants cyprinus fishes glutathione gr gsh gst gstp1 indicators juvenile lethal malondialdehyde organotin paints peroxidase pollutants recognised reductase ships tbt transferase tributyltin	abl1 adding amenable charities crizotinib crlf2 csf1r dasatinib epor etv6 flt3 funded fusions il7r lebanese lymphoblastic ntrk3 pdgfrb ph philadelphia ptk2b rearrangements responsiveness ruxolitinib sh2b3 syrian tslp tyk2 undefined
Tagcloud (Intersection) ?