GPX1 and EBNA1BP2

		GPX1	EBNA1BP2
Description		glutathione peroxidase 1	EBNA1 binding protein 2
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Lewy Body	Nucleus Chromosome Nucleolus Preribosome, Large Subunit Precursor Nuclear Periphery
	Molecular Function	Peroxidase Activity Glutathione Peroxidase Activity Protein Binding Oxidoreductase Activity SH3 Domain Binding Phospholipid-hydroperoxide Glutathione Peroxidase Activity Protein Tyrosine Kinase Binding	RNA Binding Protein Binding
	Biological Process	Response To Reactive Oxygen Species Temperature Homeostasis Endothelial Cell Development Negative Regulation Of Inflammatory Response To Antigenic Stimulus Lipid Metabolic Process Triglyceride Metabolic Process Glutathione Metabolic Process Apoptotic Process Response To Oxidative Stress Sensory Perception Of Sound Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Response To Xenobiotic Stimulus Response To Symbiotic Bacterium Response To Wounding Response To Toxic Substance UV Protection Response To Hormone Response To Glucose Response To Selenium Ion Response To Gamma Radiation Myotube Differentiation Arachidonate Metabolic Process Lipoxygenase Pathway Response To Estradiol Response To Lipopolysaccharide Response To Hydroperoxide Response To Vitamin E Regulation Of Mammary Gland Epithelial Cell Proliferation Cellular Response To Oxidative Stress Response To Nicotine Epigenetic Regulation Of Gene Expression Vasodilation Response To Hydrogen Peroxide Hydrogen Peroxide Catabolic Process Skeletal Muscle Tissue Regeneration Blood Vessel Endothelial Cell Migration Fat Cell Differentiation Myoblast Differentiation Cell Redox Homeostasis Fibroblast Proliferation Skeletal Muscle Fiber Development Neuron Apoptotic Process Myoblast Proliferation Response To Folic Acid Biological Process Involved In Interaction With Symbiont Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Heart Contraction Angiogenesis Involved In Wound Healing Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Glucose Stimulus Negative Regulation Of Release Of Cytochrome C From Mitochondria Cellular Oxidant Detoxification Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Supramolecular Fiber Organization	RRNA Processing Ribosome Biogenesis Ribosomal Large Subunit Biogenesis
Pathways		Synthesis of 5-eicosatetraenoic acids Synthesis of 12-eicosatetraenoic acid derivatives Synthesis of 15-eicosatetraenoic acid derivatives Detoxification of Reactive Oxygen Species	Major pathway of rRNA processing in the nucleolus and cytosol
Drugs		Glutathione Glutathione Glutathione disulfide Cannabidiol Benzoyl peroxide Medical Cannabis Nabiximols
Diseases		Anemia due to disorders of glutathione metabolism, including: Glucose-6-phosphate dehydrogenase (G6PD) deficiency; Glutathione peroxidase (GPX) deficiency; Gamma-glutamylcysteine synthetase (GCLC) deficiency; Glutathione synthetase (GSS) deficiency
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908 21102463) Extremely high intelligence ( 29520040) Hemoglobin levels ( 32327693) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 23128233 28067908) Intelligence (MTAG) ( 29326435) Mood instability ( 31168069) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908 25082827)	Metabolite levels ( 23823483)
Interacting Genes		6 interacting genes: ABL1 ABL2 CFTR FAM9B MAPK6 SELENBP1	5 interacting genes: CEP70 FAM9B FBXW7 FGF3 GSK3A
Entrez ID		2876	10969
HPRD ID		11749	16849
Ensembl ID		ENSG00000233276	ENSG00000117395
Uniprot IDs		A0A2R8Y6B6 P07203 Q7L4Q3	H7C2Q8 Q6IB29 Q99848
PDB IDs		2F8A	8FKP 8FKQ 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY
Enriched GO Terms of Interacting Partners?		Positive Regulation Of T Cell Migration Positive Regulation Of Establishment Of T Cell Polarity Regulation Of Establishment Of T Cell Polarity Positive Regulation Of Lymphocyte Migration Regulation Of T Cell Migration Enzyme Binding Regulation Of Vasoconstriction Regulation Of Lymphocyte Migration Enzyme Activator Activity Cellular Response To Lipid Positive Regulation Of Mononuclear Cell Migration Odontogenesis Regulation Of Modification Of Synaptic Structure Positive Regulation Of Lymphocyte Activation Regulation Of Establishment Of Cell Polarity Actin Monomer Binding Protein Tyrosine Kinase Activity Synaptonemal Complex Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Vessel Diameter Maintenance Regulation Of Osteoblast Proliferation Mismatch Repair Cell-substrate Adhesion Regulation Of Tube Size Regulation Of Establishment Or Maintenance Of Cell Polarity Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Migration Positive Regulation Of Vasoconstriction Positive Regulation Of Cell Activation Nucleotide Binding Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Cellular Response To Lipopolysaccharide Response To Lipid Magnesium Ion Binding Cellular Response To Molecule Of Bacterial Origin Cellular Response To Oxygen-containing Compound Phosphotyrosine Residue Binding Substrate Adhesion-dependent Cell Spreading Protein Localization To Cytoplasmic Microtubule Plus-end Positive Regulation Of Developmental Process Immune System Process Non-membrane Spanning Protein Tyrosine Kinase Activity Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Mitotic Cleavage Furrow Formation Prostaglandin Production Involved In Inflammatory Response Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment	Regulation Of Proteasomal Protein Catabolic Process Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Targeting To Mitochondrion Regulation Of Mitophagy Regulation Of Autophagy Of Mitochondrion Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of UDP-glucose Catabolic Process Negative Regulation Of Cardiac Muscle Tissue Development Regulation Of Mitochondrion Organization Negative Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Post-translational Protein Modification Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex Negative Regulation Of Hepatocyte Proliferation Phosphothreonine Residue Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cardiac Muscle Tissue Development Response To Symbiotic Bacterium Response To UV Response To Symbiont Negative Regulation Of Intracellular Signal Transduction Regulation Of Intrinsic Apoptotic Signaling Pathway Phospholipid-hydroperoxide Glutathione Peroxidase Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Regulation Of Microtubule Cytoskeleton Organization Regulation Of Glycogen (starch) Synthase Activity Ubiquitin Recycling Negative Regulation Of SREBP Signaling Pathway Negative Regulation Of Triglyceride Biosynthetic Process Negative Regulation Of Osteoclast Development Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Ubiquitination Regulation Of Macroautophagy Lewy Body Positive Regulation Of Proteolysis Autosome Genomic Imprinting Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
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