CKAP2 and SREK1

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		CKAP2	SREK1
Description		cytoskeleton associated protein 2	splicing regulatory glutamic acid and lysine rich protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Spindle Pole Nucleolus Cytoplasm Centrosome Spindle Cytoskeleton Microtubule Cilium Microtubule Cytoskeleton Ciliary Basal Body Mitotic Spindle	Nucleus Nucleoplasm Spliceosomal Complex Nuclear Speck
	Molecular Function		Nucleic Acid Binding RNA Binding Protein Binding
	Biological Process	Mitotic Cytokinesis Apoptotic Process Negative Regulation Of Microtubule Depolymerization Positive Regulation Of Transcription By RNA Polymerase II	MRNA Processing RNA Splicing
Pathways
Drugs
Diseases
GWAS			Logical memory (delayed recall) in mild cognitive impairment ( 29274321) Systolic blood pressure ( 30224653)
Interacting Genes		7 interacting genes: AGR2 FBXO7 LRRK1 SREK1 TTC3 UBE2C YWHAG	66 interacting genes: ARL6IP4 CD8A CKAP2 CSNK2A1 DDX17 DDX39B DDX3X DGKA DGKD EFTUD2 ELAVL1 GPRASP2 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPC HNRNPD HNRNPH1 HNRNPK HNRNPU ILF2 MDM2 MRPL37 NAT10 NCL NPM1 PABPC1 PABPC4 PARP1 PCBP3 PIN1 PRPF40A RAB5C RACK1 RBM10 RBM39 RBMX SAFB SF3A3 SF3B3 SFPQ SH3GLB2 SNRPD1 SNRPD3 SRPK1 SRPK2 SRPK3 SRRM4 SRSF1 SRSF10 SRSF11 SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF8 SSRP1 SUPT16H TARBP1 THRAP3 TRA2B TXLNA YBX1 ZRANB2
Entrez ID		26586	140890
HPRD ID		10832	18043
Ensembl ID		ENSG00000136108	ENSG00000153914
Uniprot IDs		Q8WWK9	Q8WXA9
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Protein K48-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Ubiquitination Ubiquitin-protein Transferase Activity Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Post-translational Protein Modification SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin Ligase Complex Proteolysis Protein Kinase C Inhibitor Activity Negative Regulation Of Hemopoiesis Lung Goblet Cell Differentiation Lewy Body Core Negative Regulation Of Immune System Process Positive Regulation Of PERK-mediated Unfolded Protein Response Positive Regulation Of Exit From Mitosis Protein Catabolic Process Negative Regulation Of Hematopoietic Stem Cell Proliferation Negative Regulation Of Lymphocyte Activation Positive Regulation Of Ubiquitin Protein Ligase Activity Free Ubiquitin Chain Polymerization Osteoclast Development	RNA Splicing RNA Binding MRNA Processing MRNA Metabolic Process RNA Processing Regulation Of MRNA Processing Regulation Of MRNA Metabolic Process RNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Nucleic Acid Binding Regulation Of RNA Splicing RNA Splicing, Via Transesterification Reactions Nucleic Acid Metabolic Process MRNA Splicing, Via Spliceosome Nucleobase-containing Compound Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Binding Nuclear Speck Negative Regulation Of MRNA Metabolic Process Catalytic Step 2 Spliceosome Spliceosomal Complex Ribonucleoprotein Complex Nucleoplasm Nucleus Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Splicing Regulation Of Primary Metabolic Process MRNA Stabilization Regulation Of Gene Expression Spliceosomal Complex Assembly Protein-RNA Complex Assembly Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of MRNA Catabolic Process RNA Stabilization Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Catabolic Process Regulation Of MRNA Stability Regulation Of RNA Stability Alternative MRNA Splicing, Via Spliceosome Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression Pre-mRNA Binding Negative Regulation Of Macromolecule Biosynthetic Process
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