CKAP2 and AGR2

Number of citations of the paper that reports this interaction (PubMedID 20888340)
0

Data Source:
BioGRID (two hybrid)

		CKAP2	AGR2
Description		cytoskeleton associated protein 2	anterior gradient 2, protein disulphide isomerase family member
Image		No pdb structure
GO Annotations	Cellular Component	Spindle Pole Nucleolus Cytoplasm Centrosome Spindle Cytoskeleton Microtubule Cilium Microtubule Cytoskeleton Ciliary Basal Body Mitotic Spindle	Extracellular Region Extracellular Space Endoplasmic Reticulum
	Molecular Function		Dystroglycan Binding Epidermal Growth Factor Receptor Binding Protein Binding Identical Protein Binding
	Biological Process	Mitotic Cytokinesis Apoptotic Process Negative Regulation Of Microtubule Depolymerization Positive Regulation Of Transcription By RNA Polymerase II	Inflammatory Response Positive Regulation Of Gene Expression Positive Regulation Of Cell-substrate Adhesion Response To Endoplasmic Reticulum Stress Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Digestive Tract Morphogenesis Positive Regulation Of Developmental Growth Lung Goblet Cell Differentiation Mucus Secretion Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of PERK-mediated Unfolded Protein Response
Pathways
Drugs
Diseases
GWAS			Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) ( 23648065) Iron status biomarkers (ferritin levels) ( 28334935) Residual cognition ( 28441426) Type 2 diabetes (dietary heme iron intake interaction) ( 23386860)
Interacting Genes		7 interacting genes: AGR2 FBXO7 LRRK1 SREK1 TTC3 UBE2C YWHAG	87 interacting genes: ANKRD11 APOBEC3B APP ASPH BORCS8 BORCS8-MEF2B BRD7 C3 CAMLG CATSPER1 CCDC90B CD34 CD68 CDKN2AIPNL CETN3 CKAP2 CLIC3 CNNM3 CPNE6 CRCP CREB1 CRMP1 CRYGA CYB5R2 DAG1 DCAF11 EIF3F FABP2 FAM110A FAM117B GET3 GPSM2 GRB2 GUCA1A HCK HMG20A HSD3B7 IL36RN IMPDH2 KLHL38 KRT31 LSM1 LYPD3 MBD3 MBLAC1 MED31 MLH1 NDUFB2 NRF1 NRIP1 NSD1 NTAQ1 NUP54 NUP58 NUP62CL OSTF1 PHC3 POGZ POLR2L POM121 PSMA1 PSMB1 PSORS1C2 PTTG2 RBFOX1 RBP5 RIIAD1 RTL4 RUVBL2 SDC3 SGTA SGTB SH2D1B STK16 TCEA2 TFAP2D THOC1 TLE5 TMEM123 TRAF2 TSTD2 UBE2I UBQLN1 UBQLN2 UBQLN4 USP20 VEZF1
Entrez ID		26586	10551
HPRD ID		10832	05896
Ensembl ID		ENSG00000136108	ENSG00000106541
Uniprot IDs		Q8WWK9	O95994 Q4JM46
PDB IDs			2LNS 2LNT
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Protein K48-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Ubiquitination Ubiquitin-protein Transferase Activity Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Post-translational Protein Modification SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin Ligase Complex Proteolysis Protein Kinase C Inhibitor Activity Negative Regulation Of Hemopoiesis Lung Goblet Cell Differentiation Lewy Body Core Negative Regulation Of Immune System Process Positive Regulation Of PERK-mediated Unfolded Protein Response Positive Regulation Of Exit From Mitosis Protein Catabolic Process Negative Regulation Of Hematopoietic Stem Cell Proliferation Negative Regulation Of Lymphocyte Activation Positive Regulation Of Ubiquitin Protein Ligase Activity Free Ubiquitin Chain Polymerization Osteoclast Development	Nuclear Pore Structural Constituent Of Nuclear Pore TRC Complex Positive Regulation Of Response To Endoplasmic Reticulum Stress GET Complex Tail-anchored Membrane Protein Insertion Into ER Membrane RNA Transport Positive Regulation Of ERAD Pathway Protein Binding Nucleus Homologous Chromosome Segregation Regulation Of ERAD Pathway
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