CTTN and SDC3

Number of citations of the paper that reports this interaction (PMID 9553134)
37

Data Source:
HPRD (in vitro)

		CTTN	SDC3
Gene Name		cortactin	syndecan 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Cytoplasm Cytoskeleton Actin Filament Coated Pit Focal Adhesion Cell Cortex Voltage-gated Potassium Channel Complex Lamellipodium Growth Cone Cortical Cytoskeleton Dendritic Spine Extracellular Vesicular Exosome Mitotic Spindle Midzone	Golgi Lumen Plasma Membrane Membrane Integral Component Of Membrane Lysosomal Lumen
	Molecular Function	Protein Binding
	Biological Process	Intracellular Protein Transport Receptor-mediated Endocytosis Substrate-dependent Cell Migration, Cell Extension Actin Filament Polymerization Regulation Of Axon Extension Positive Regulation Of Actin Filament Polymerization Actin Cytoskeleton Reorganization Focal Adhesion Assembly Neuron Projection Morphogenesis Cell Motility Dendritic Spine Maintenance Lamellipodium Organization Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Retinoid Metabolic Process Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Phototransduction, Visible Light Pathogenesis Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Small Molecule Metabolic Process
Pathways			MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type Heparan sulfate/heparin (HS-GAG) metabolism MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Defective CHST14 causes EDS, musculocontractural type Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis MPS IIIC - Sanfilippo syndrome C Retinoid metabolism and transport Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Non-integrin membrane-ECM interactions Diseases associated with visual transduction Defective EXT1 causes exostoses 1, TRPS2 and CHDS Syndecan interactions MPS IV - Morquio syndrome A Visual phototransduction MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS MPS VII - Sly syndrome Metabolism of carbohydrates HS-GAG biosynthesis HS-GAG degradation MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS
Protein-Protein Interactions		36 interactors: ACD ACTA1 ACTG1 ACTR2 ACTR3 ANKZF1 ARHGAP17 ARHGAP8 CASP3 CD2AP CHD3 CTNND1 CTNND2 CTTNBP2 DNM1 DNM2 FER FGD1 GRB2 HAX1 HDAC6 HIP1R KCNA2 MET MYLK SDC3 SHANK2 SIRT1 SPRR2A SRC SYK TINF2 TJP1 TNK2 WASL WIPF1	15 interactors: CASK COL5A1 CSK CTTN CUX1 EPHB4 FGF2 FYN KRTAP10-3 KRTAP5-9 MDK PTN TUBA1A TUBB TUBB2A
Entrez ID		2017	9672
HPRD ID		01268	01719
Ensembl ID		ENSG00000085733
Uniprot IDs		Q14247 Q53HG7	O75056
PDB IDs		1X69 2D1X
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Anatomical Structure Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Endocytosis Fc Receptor Signaling Pathway Cellular Response To Stimulus Cellular Component Assembly Regulation Of Cellular Component Organization Actin Cytoskeleton Organization Actin Filament-based Process Anatomical Structure Development Response To External Stimulus Developmental Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Organelle Organization Phagocytosis Cell Communication Positive Regulation Of Organelle Organization Multicellular Organismal Development Immune Response-activating Cell Surface Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Organelle Organization Movement Of Cell Or Subcellular Component Chemotaxis Immune Response-regulating Signaling Pathway System Development Signaling Cytoskeleton Organization Signal Transduction Positive Regulation Of Immune System Process Response To Stimulus Cell Projection Organization Cell Morphogenesis Involved In Differentiation Axon Guidance Locomotion Innate Immune Response Positive Regulation Of Protein Complex Assembly Regulation Of Immune System Process Cell Morphogenesis Actin Filament Organization Positive Regulation Of Immune Response Neuron Projection Morphogenesis Positive Regulation Of Cellular Component Biogenesis Regulation Of Immune Response Peptidyl-tyrosine Autophosphorylation Regulation Of Protein Complex Assembly Positive Regulation Of Cytoskeleton Organization	Cell Migration Cell Motility Protein Polymerization Movement Of Cell Or Subcellular Component Nervous System Development Locomotion Anatomical Structure Development Organ Development System Development Developmental Process Response To Wounding Cellular Protein Complex Assembly Multicellular Organismal Development Positive Regulation Of Cell Division Cell Migration Involved In Sprouting Angiogenesis Enzyme Linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Blood Vessel Endothelial Cell Migration Neurogenesis Protein Autophosphorylation Cell Differentiation Peptidyl-tyrosine Autophosphorylation Tissue Development Epithelium Development Neuron Differentiation Wound Healing Chemotaxis Cellular Macromolecular Complex Assembly Neuron Projection Morphogenesis Cell Adhesion Regulation Of Cell Division Learning Or Memory Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Peptidyl-tyrosine Phosphorylation Sprouting Angiogenesis 'de Novo' Posttranslational Protein Folding Cognition 'de Novo' Protein Folding Defecation Growth Factor Dependent Regulation Of Skeletal Muscle Satellite Cell Proliferation Integrin Biosynthetic Process Cellular Response To Peptide Hormone Stimulus Defense Response Negative Regulation Of Wound Healing Cellular Response To Peptide T Cell Costimulation Innate Immune Response Neuron Projection Development Endothelial Cell Migration
Tagcloud ?		applicability csmd1 delineate emphasized fadd fgf4 fhit floor gains gata4 imbalances individualized losses mandatory mccc1 mlpa mouth mtus1 multiplex p428 panel probe probemix propensity ptk2 rarb relapses tier wisp1	artemin artn benign carcinoma diverse gfralpha1 gfralpha3 herein invasiveness largely malignancies mammary mediating metastases namely node oncogenicity outcome positively positivity predictors promoting relapse restricted significance syndecan synergistic univariate upstream
Tagcloud (Difference) ?		applicability csmd1 delineate emphasized fadd fgf4 fhit floor gains gata4 imbalances individualized losses mandatory mccc1 mlpa mouth mtus1 multiplex p428 panel probe probemix propensity ptk2 rarb relapses tier wisp1	artemin artn benign carcinoma diverse gfralpha1 gfralpha3 herein invasiveness largely malignancies mammary mediating metastases namely node oncogenicity outcome positively positivity predictors promoting relapse restricted significance syndecan synergistic univariate upstream
Tagcloud (Intersection) ?