CTTN and HAX1

Number of citations: 0 (PubMedID 15159385)
Data Source: HPRD (in vitro)

		CTTN	HAX1
Name		cortactin	HCLS1 associated protein X-1
Structure			No pdb structure
GO Annotations	Cellular Component	Ruffle Podosome Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoskeleton Actin Filament Plasma Membrane Clathrin-coated Pit Focal Adhesion Cell Cortex Voltage-gated Potassium Channel Complex Membrane Lamellipodium Cell Junction Endocytic Vesicle Dendrite Growth Cone Cortical Cytoskeleton Cell Projection Dendritic Spine Synapse Anchoring Junction Postsynapse Postsynaptic Actin Cytoskeleton Glutamatergic Synapse Mitotic Spindle Midzone	P-body Nucleus Nuclear Envelope Transcription Regulator Complex Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Intermembrane Space Mitochondrial Matrix Endoplasmic Reticulum Plasma Membrane Cell Cortex Actin Cytoskeleton Membrane Apical Plasma Membrane Sarcoplasmic Reticulum Lamellipodium Clathrin-coated Vesicle Cytoplasmic Vesicle Nuclear Membrane
	Molecular Function	Protein Binding Profilin Binding Cadherin Binding Proline-rich Region Binding Arp2/3 Complex Binding	Protein Binding Protein Domain Specific Binding Interleukin-1 Binding Signaling Adaptor Activity
	Biological Process	Intracellular Protein Transport Endocytosis Receptor-mediated Endocytosis Substrate-dependent Cell Migration, Cell Extension Signal Transduction Actin Cytoskeleton Organization Regulation Of Axon Extension Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Smooth Muscle Contraction Focal Adhesion Assembly Neuron Projection Morphogenesis Cell Motility Positive Regulation Of Chemotaxis Regulation Of Cell Projection Assembly Dendritic Spine Maintenance Extrinsic Apoptotic Signaling Pathway Lamellipodium Organization Modification Of Postsynaptic Actin Cytoskeleton Modification Of Postsynaptic Structure Regulation Of Mitophagy Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Mitochondrion Organization Regulation Of Actin Filament Polymerization Positive Regulation Of Granulocyte Differentiation Granulocyte Colony-stimulating Factor Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Cytokine Stimulus Regulation Of Actin Filament Organization Regulation Of Autophagy Of Mitochondrion Regulation Of Protein Targeting To Mitochondrion
Pathways		RHO GTPases activate PAKs Clathrin-mediated endocytosis	None
Diseases		None	Neutropenic disorders, including the following three diseases: Kostmann syndrome; Cyclic neutropenia; X-linked neutropenia/myelodysplasia
GWAS		No GWAS studies recorded	Bipolar disorder ( 31043756 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (min-P) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (min-P) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Fish- and plant-related diet ( 32066663 ) Mean spheric corpuscular volume ( 32888494 ) Nicotine dependence ( 28440896 ) Non-albumin protein levels ( 29403010 ) Reticulocyte count ( 32888494 ) Serum total protein levels ( 29403010 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Triglyceride levels ( 32203549 )
Interacting Genes		58 interacting genes: ACD ACTA1 ACTG1 ACTR3 ANKZF1 ARHGAP17 ARHGAP8 ATM CASP3 CD2AP CHD3 CPSF7 CTNND1 CTNND2 CTTNBP2 DNM1 DNM2 EGFR FER FGD1 GRB2 GRIA2 GTSE1 HAX1 HIP1R KCNA2 KEAP1 MET MYLK NHSL2 NXF1 PRPF6 RBM15 RPL23A RPL37 RPL9 RSPH1 SDC3 SF1 SF3B4 SFPQ SH3BP2 SHANK2 SHANK3 SIRT1 SMURF1 SPRR2A SRC SYK TINF2 TJP1 TNK2 TRIM15 USP7 WASL WIPF1 YTHDF1 YTHDF3	26 interacting genes: ABCB1 ABCB11 ABCB4 BIRC3 CTTN DGKD EIF3F HCLS1 HNF4G IL1A KIAA0513 MAPK10 NEDD4L PKD2 POLR1D POLR1H PPP3CC PRNP RBX1 RNF217 RPA1 STAT5B SVIL WEE2-AS1 YWHAQ ZNF420
Entrez ID		2017	10456
HPRD ID		01268	12075
Ensembl ID		ENSG00000085733	ENSG00000143575
Uniprot IDs		Q14247 Q53HG7	A0A0S2Z565 A0A0S2Z591 O00165
PDB IDs		1X69 2D1X	Not available
GO Terms Enriched among Interactors		SH3 Domain Binding Cellular Component Assembly Cytoplasm Regulation Of Cellular Component Organization Anchoring Junction Lamellipodium Regulation Of Actin Cytoskeleton Organization Regulation Of Organelle Organization Actin Cytoskeleton Actin Filament Regulation Of Actin Filament-based Process Cytosol Organelle Organization Actin Filament Organization Regulation Of Actin Filament Organization Cellular Response To Chemical Stress Protein Tyrosine Kinase Activity Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Metabolic Process Negative Regulation Of Telomere Maintenance Actin Filament-based Process Regulation Of Cytoskeleton Organization Vesicle Scission Negative Regulation Of Membrane Tubulation Podosome Grb2-EGFR Complex Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of TOR Signaling Cell Projection Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Vesicle-mediated Transport Postsynapse Organization Response To Reactive Oxygen Species Regulation Of Chromosome Organization Positive Regulation Of Cellular Component Organization Cytoskeleton Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Postsynaptic Density Regulation Of Signal Transduction Actin Cytoskeleton Organization Dendritic Spine Morphogenesis Regulation Of Clathrin-dependent Endocytosis Response To Oxidative Stress Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Telomere Maintenance Cellular Response To Reactive Oxygen Species Regulation Of Autophagy Regulation Of Supramolecular Fiber Organization	Ceramide Floppase Activity Ceramide Translocation Cytosol Regulation Of Transport Sphingolipid Translocation Phosphatidylcholine Floppase Activity ABC-type Transporter Activity Intercellular Canaliculus Regulation Of Monoatomic Ion Transport Regulation Of Calcium Ion Import Transmembrane Transporter Binding Dendritic Spine Maintenance ATPase-coupled Intramembrane Lipid Transporter Activity Regulation Of Interleukin-2 Production Homeostatic Process Xenobiotic Export From Cell ABC-type Xenobiotic Transporter Activity Regulation Of Calcium Ion Import Across Plasma Membrane RNA Polymerase I Complex Negative Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Transport Ceramide Transport Intracellular Signal Transduction Cytokine-mediated Signaling Pathway Cytoplasm Negative Regulation Of Monoatomic Ion Transport Ubiquitin-protein Transferase Activity Regulation Of Cell Cycle Regulation Of Actin Filament Polymerization Regulation Of Actin Polymerization Or Depolymerization Dendritic Spine Organization Response To Copper Ion Multicellular Organismal-level Homeostasis Positive Regulation Of Interleukin-2 Production Cellular Response To Nonylphenol Response To Quercetin Cellular Response To Borneol Response To Codeine Phospholipid Translocation ATPase-coupled Transmembrane Transporter Activity Daunorubicin Transport Positive Regulation Of Establishment Of Sertoli Cell Barrier Metanephric Cortical Collecting Duct Development Metanephric Cortex Development Metanephric Distal Tubule Development Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Calcineurin-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Transmembrane Transport Type 8 Metabotropic Glutamate Receptor Binding