CTTN and ARHGAP8

Number of citations of the paper that reports this interaction (PMID 15064355)
7

Data Source:
HPRD (in vitro, in vivo)

		CTTN	ARHGAP8
Gene Name		cortactin	Rho GTPase activating protein 8
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Cytoplasm Cytoskeleton Actin Filament Coated Pit Focal Adhesion Cell Cortex Voltage-gated Potassium Channel Complex Lamellipodium Growth Cone Cortical Cytoskeleton Dendritic Spine Extracellular Vesicular Exosome Mitotic Spindle Midzone	Cytosol
	Molecular Function	Protein Binding	Rho GTPase Activator Activity Protein Binding
	Biological Process	Intracellular Protein Transport Receptor-mediated Endocytosis Substrate-dependent Cell Migration, Cell Extension Actin Filament Polymerization Regulation Of Axon Extension Positive Regulation Of Actin Filament Polymerization Actin Cytoskeleton Reorganization Focal Adhesion Assembly Neuron Projection Morphogenesis Cell Motility Dendritic Spine Maintenance Lamellipodium Organization Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Small GTPase Mediated Signal Transduction Positive Regulation Of Rho GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade
Pathways			Rho GTPase cycle Signaling by Rho GTPases
Drugs
Diseases
GWAS			Electroencephalographic traits in alcoholism ( 22554406)
Protein-Protein Interactions		36 interactors: ACD ACTA1 ACTG1 ACTR2 ACTR3 ANKZF1 ARHGAP17 ARHGAP8 CASP3 CD2AP CHD3 CTNND1 CTNND2 CTTNBP2 DNM1 DNM2 FER FGD1 GRB2 HAX1 HDAC6 HIP1R KCNA2 MET MYLK SDC3 SHANK2 SIRT1 SPRR2A SRC SYK TINF2 TJP1 TNK2 WASL WIPF1	4 interactors: BNIP2 CTTN RHOA SH3GL1
Entrez ID		2017	23779
HPRD ID		01268	06448
Ensembl ID		ENSG00000085733	ENSG00000241484
Uniprot IDs		Q14247 Q53HG7	A6ZJ79 P85298 Q6PJW1
PDB IDs		1X69 2D1X
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Anatomical Structure Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Endocytosis Fc Receptor Signaling Pathway Cellular Response To Stimulus Cellular Component Assembly Regulation Of Cellular Component Organization Actin Cytoskeleton Organization Actin Filament-based Process Anatomical Structure Development Response To External Stimulus Developmental Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Organelle Organization Phagocytosis Cell Communication Positive Regulation Of Organelle Organization Multicellular Organismal Development Immune Response-activating Cell Surface Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Organelle Organization Movement Of Cell Or Subcellular Component Chemotaxis Immune Response-regulating Signaling Pathway System Development Signaling Cytoskeleton Organization Signal Transduction Positive Regulation Of Immune System Process Response To Stimulus Cell Projection Organization Cell Morphogenesis Involved In Differentiation Axon Guidance Locomotion Innate Immune Response Positive Regulation Of Protein Complex Assembly Regulation Of Immune System Process Cell Morphogenesis Actin Filament Organization Positive Regulation Of Immune Response Neuron Projection Morphogenesis Positive Regulation Of Cellular Component Biogenesis Regulation Of Immune Response Peptidyl-tyrosine Autophosphorylation Regulation Of Protein Complex Assembly Positive Regulation Of Cytoskeleton Organization	Regulation Of Neuron Differentiation Nervous System Development Regulation Of Neurogenesis Regulation Of Cell Development Regulation Of Axonogenesis Cell Junction Assembly Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Cell-cell Junction Organization Skeletal Muscle Satellite Cell Migration Apolipoprotein A-I-mediated Signaling Pathway System Development Positive Regulation Of Cellular Component Biogenesis Cleavage Furrow Formation Generation Of Neurons Regulation Of Cell Differentiation Positive Regulation Of Neuron Differentiation Dendritic Spine Maintenance Neurogenesis Regulation Of Actin Cytoskeleton Organization Regulation Of Neuron Projection Development Substrate-dependent Cell Migration, Cell Extension Multicellular Organismal Development Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Positive Regulation Of Neurogenesis Anatomical Structure Development Microtubule Cytoskeleton Organization Regulation Of Cell Morphogenesis Regulation Of Cell Projection Organization Regulation Of Cytoskeleton Organization Positive Regulation Of Cell Development Ossification Involved In Bone Maturation Developmental Process Bone Maturation Negative Chemotaxis Mitotic Spindle Assembly Dendritic Spine Organization Actin Cytoskeleton Organization Positive Regulation Of NF-kappaB Import Into Nucleus Regulation Of Osteoblast Proliferation Cellular Component Maintenance Neuron Projection Morphogenesis Actin Filament-based Process Endocytosis Focal Adhesion Assembly Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Signal Transduction Substrate-dependent Cell Migration Microtubule-based Process
Tagcloud ?		applicability csmd1 delineate emphasized fadd fgf4 fhit floor gains gata4 imbalances individualized losses mandatory mccc1 mlpa mouth mtus1 multiplex p428 panel probe probemix propensity ptk2 rarb relapses tier wisp1
Tagcloud (Difference) ?		applicability csmd1 delineate emphasized fadd fgf4 fhit floor gains gata4 imbalances individualized losses mandatory mccc1 mlpa mouth mtus1 multiplex p428 panel probe probemix propensity ptk2 rarb relapses tier wisp1
Tagcloud (Intersection) ?