CTTN and HIP1R

Number of citations of the paper that reports this interaction (PMID 17318189)
35

Data Source:
HPRD (in vitro, in vivo)

		CTTN	HIP1R
Gene Name		cortactin	huntingtin interacting protein 1 related
Image
Gene Ontology Annotations	Cellular Component	Ruffle Cytoplasm Cytoskeleton Actin Filament Coated Pit Focal Adhesion Cell Cortex Voltage-gated Potassium Channel Complex Lamellipodium Growth Cone Cortical Cytoskeleton Dendritic Spine Extracellular Vesicular Exosome Mitotic Spindle Midzone	Cytoplasm Cytoskeleton Coated Pit Clathrin-coated Vesicle Clathrin-coated Vesicle Membrane Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding	Actin Binding Protein Binding Protein Binding, Bridging Phosphatidylinositol Binding
	Biological Process	Intracellular Protein Transport Receptor-mediated Endocytosis Substrate-dependent Cell Migration, Cell Extension Actin Filament Polymerization Regulation Of Axon Extension Positive Regulation Of Actin Filament Polymerization Actin Cytoskeleton Reorganization Focal Adhesion Assembly Neuron Projection Morphogenesis Cell Motility Dendritic Spine Maintenance Lamellipodium Organization Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Receptor-mediated Endocytosis Actin Cytoskeleton Organization
Pathways			Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding
Drugs
Diseases
GWAS			Parkinson's disease ( 21292315)
Protein-Protein Interactions		36 interactors: ACD ACTA1 ACTG1 ACTR2 ACTR3 ANKZF1 ARHGAP17 ARHGAP8 CASP3 CD2AP CHD3 CTNND1 CTNND2 CTTNBP2 DNM1 DNM2 FER FGD1 GRB2 HAX1 HDAC6 HIP1R KCNA2 MET MYLK SDC3 SHANK2 SIRT1 SPRR2A SRC SYK TINF2 TJP1 TNK2 WASL WIPF1	8 interactors: ACTA1 CLTA CLTB CLTC CTTN DYNLL1 HIP1 HTT
Entrez ID		2017	9026
HPRD ID		01268	10412
Ensembl ID		ENSG00000085733	ENSG00000130787
Uniprot IDs		Q14247 Q53HG7	B3KN98 B3KQW8 O75146 Q6NXG8
PDB IDs		1X69 2D1X	1R0D
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Anatomical Structure Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Endocytosis Fc Receptor Signaling Pathway Cellular Response To Stimulus Cellular Component Assembly Regulation Of Cellular Component Organization Actin Cytoskeleton Organization Actin Filament-based Process Anatomical Structure Development Response To External Stimulus Developmental Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Organelle Organization Phagocytosis Cell Communication Positive Regulation Of Organelle Organization Multicellular Organismal Development Immune Response-activating Cell Surface Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Organelle Organization Movement Of Cell Or Subcellular Component Chemotaxis Immune Response-regulating Signaling Pathway System Development Signaling Cytoskeleton Organization Signal Transduction Positive Regulation Of Immune System Process Response To Stimulus Cell Projection Organization Cell Morphogenesis Involved In Differentiation Axon Guidance Locomotion Innate Immune Response Positive Regulation Of Protein Complex Assembly Regulation Of Immune System Process Cell Morphogenesis Actin Filament Organization Positive Regulation Of Immune Response Neuron Projection Morphogenesis Positive Regulation Of Cellular Component Biogenesis Regulation Of Immune Response Peptidyl-tyrosine Autophosphorylation Regulation Of Protein Complex Assembly Positive Regulation Of Cytoskeleton Organization	Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Intracellular Protein Transport Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Cytoskeleton Organization Actin Cytoskeleton Organization Cellular Protein Localization Actin Filament-based Process Protein Transport Endocytosis Establishment Of Protein Localization Antigen Processing And Presentation Of Peptide Antigen Intracellular Transport Golgi Vesicle Transport Antigen Processing And Presentation Membrane Organization Transport Organelle Organization Protein Localization Establishment Of Localization In Cell Cell Differentiation Developmental Process Neural Plate Formation Post-Golgi Vesicle-mediated Transport Cellular Localization Anatomical Structure Morphogenesis Serotonin Uptake Skeletal Muscle Fiber Adaptation Lactate Biosynthetic Process From Pyruvate Regulation Of Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Movement Of Cell Or Subcellular Component Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Negative Regulation Of Cerebellar Granule Cell Precursor Proliferation Negative Regulation Of Hyaluronan Biosynthetic Process Regulation Of Protein Phosphatase Type 2A Activity Regulation Of Cell Death Mitotic Cell Cycle Process Quinolinate Biosynthetic Process Negative Regulation Of Synaptic Transmission, Dopaminergic Positive Regulation Of Transport Mitotic Cell Cycle Lactate Biosynthetic Process Cell Development Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Paraxial Mesoderm Formation Cellular Component Assembly Quinolinate Metabolic Process
Tagcloud ?		applicability csmd1 delineate emphasized fadd fgf4 fhit floor gains gata4 imbalances individualized losses mandatory mccc1 mlpa mouth mtus1 multiplex p428 panel probe probemix propensity ptk2 rarb relapses tier wisp1	avoided balanced ccdc62 desipramine dextromethorphan escitalopram favorably fluoxetine gba gdnf haloperidol investigative lithium mapt neurogenesis neuroinflammation neuroprotective pathobiological pathobiology pramipexole priorities proteasomal psychotropics replicated rns safest salutary trophic valproate
Tagcloud (Difference) ?		applicability csmd1 delineate emphasized fadd fgf4 fhit floor gains gata4 imbalances individualized losses mandatory mccc1 mlpa mouth mtus1 multiplex p428 panel probe probemix propensity ptk2 rarb relapses tier wisp1	avoided balanced ccdc62 desipramine dextromethorphan escitalopram favorably fluoxetine gba gdnf haloperidol investigative lithium mapt neurogenesis neuroinflammation neuroprotective pathobiological pathobiology pramipexole priorities proteasomal psychotropics replicated rns safest salutary trophic valproate
Tagcloud (Intersection) ?