CTTN and SPRR2A

Number of citations: 59 (PubMedID 18155796)
Data Source: BioGRID (pull down)

		CTTN	SPRR2A
Name		cortactin	small proline rich protein 2A
Structure			No pdb structure
GO Annotations	Cellular Component	Ruffle Podosome Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoskeleton Actin Filament Plasma Membrane Clathrin-coated Pit Focal Adhesion Cell Cortex Voltage-gated Potassium Channel Complex Membrane Lamellipodium Cell Junction Endocytic Vesicle Dendrite Growth Cone Cortical Cytoskeleton Cell Projection Dendritic Spine Synapse Anchoring Junction Postsynapse Postsynaptic Actin Cytoskeleton Glutamatergic Synapse Mitotic Spindle Midzone	Cornified Envelope Extracellular Region Cytoplasm Cytosol Transport Vesicle Secretory Granule Cytoplasmic Vesicle
	Molecular Function	Protein Binding Profilin Binding Cadherin Binding Proline-rich Region Binding Arp2/3 Complex Binding	Protein Binding Lipid Binding
	Biological Process	Intracellular Protein Transport Endocytosis Receptor-mediated Endocytosis Substrate-dependent Cell Migration, Cell Extension Signal Transduction Actin Cytoskeleton Organization Regulation Of Axon Extension Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Smooth Muscle Contraction Focal Adhesion Assembly Neuron Projection Morphogenesis Cell Motility Positive Regulation Of Chemotaxis Regulation Of Cell Projection Assembly Dendritic Spine Maintenance Extrinsic Apoptotic Signaling Pathway Lamellipodium Organization Modification Of Postsynaptic Actin Cytoskeleton Modification Of Postsynaptic Structure Regulation Of Mitophagy Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Antibacterial Humoral Response Defense Response To Bacterium Host-mediated Modulation Of Intestinal Microbiota Composition Defense Response To Gram-positive Bacterium
Pathways		RHO GTPases activate PAKs Clathrin-mediated endocytosis	Formation of the cornified envelope Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
GWAS		No GWAS studies recorded	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359 ) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359 ) Asthma ( 31619474 ) Asthma or allergic disease (pleiotropy) ( 29785011 )
Interacting Genes		58 interacting genes: ACD ACTA1 ACTG1 ACTR3 ANKZF1 ARHGAP17 ARHGAP8 ATM CASP3 CD2AP CHD3 CPSF7 CTNND1 CTNND2 CTTNBP2 DNM1 DNM2 EGFR FER FGD1 GRB2 GRIA2 GTSE1 HAX1 HIP1R KCNA2 KEAP1 MET MYLK NHSL2 NXF1 PRPF6 RBM15 RPL23A RPL37 RPL9 RSPH1 SDC3 SF1 SF3B4 SFPQ SH3BP2 SHANK2 SHANK3 SIRT1 SMURF1 SPRR2A SRC SYK TINF2 TJP1 TNK2 TRIM15 USP7 WASL WIPF1 YTHDF1 YTHDF3	10 interacting genes: ABL1 AKT2 CRK CTTN DLG4 EVPL HCK ITK PEX13 YES1
Entrez ID		2017	6700
HPRD ID		01268	01649
Ensembl ID		ENSG00000085733	ENSG00000241794
Uniprot IDs		Q14247 Q53HG7	P35326
PDB IDs		1X69 2D1X	Not available
GO Terms Enriched among Interactors		SH3 Domain Binding Cellular Component Assembly Cytoplasm Regulation Of Cellular Component Organization Anchoring Junction Lamellipodium Regulation Of Actin Cytoskeleton Organization Regulation Of Organelle Organization Actin Cytoskeleton Actin Filament Regulation Of Actin Filament-based Process Cytosol Organelle Organization Actin Filament Organization Regulation Of Actin Filament Organization Cellular Response To Chemical Stress Protein Tyrosine Kinase Activity Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Metabolic Process Negative Regulation Of Telomere Maintenance Actin Filament-based Process Regulation Of Cytoskeleton Organization Vesicle Scission Negative Regulation Of Membrane Tubulation Podosome Grb2-EGFR Complex Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of TOR Signaling Cell Projection Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Vesicle-mediated Transport Postsynapse Organization Response To Reactive Oxygen Species Regulation Of Chromosome Organization Positive Regulation Of Cellular Component Organization Cytoskeleton Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Postsynaptic Density Regulation Of Signal Transduction Actin Cytoskeleton Organization Dendritic Spine Morphogenesis Regulation Of Clathrin-dependent Endocytosis Response To Oxidative Stress Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Telomere Maintenance Cellular Response To Reactive Oxygen Species Regulation Of Autophagy Regulation Of Supramolecular Fiber Organization	Phosphotyrosine Residue Binding Non-membrane Spanning Protein Tyrosine Kinase Activity Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Protein Tyrosine Kinase Activity Fc-gamma Receptor Signaling Pathway Cytosol Ephrin Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Fc Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Protein Kinase Activity Regulation Of Immune Response Response To Transforming Growth Factor Beta Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Motility Actin Filament Immune Response-regulating Cell Surface Receptor Signaling Pathway Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Actin Cytoskeleton Organization Immune Response-activating Signaling Pathway Proline-rich Region Binding Regulation Of Actin Filament-based Process Anchoring Junction Immune Response-regulating Signaling Pathway Activation Of Immune Response Cellular Response To Oxygen-containing Compound Response To Reactive Oxygen Species Ephrin Receptor Binding Cell Migration Cortical Cytoskeleton Positive Regulation Of Supramolecular Fiber Organization Negative Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Immune System Process Dendritic Spine Organization Positive Regulation Of Cytoskeleton Organization Protein Modification Process Regulation Of Cytoskeleton Organization Negative Regulation Of Immune Response Regulation Of Biological Quality Intracellular Protein Localization SH2 Domain Binding Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Neuron Projection Organization Postsynapse Organization Postsynapse Leukocyte Migration Positive Regulation Of Locomotion