CTTN and SHANK2

Number of citations: 79 (PubMedID 9742101)
Data Source: HPRD (two hybrid, in vitro, in vivo)

		CTTN	SHANK2
Name		cortactin	SH3 and multiple ankyrin repeat domains 2
Structure
GO Annotations	Cellular Component	Ruffle Podosome Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoskeleton Actin Filament Plasma Membrane Clathrin-coated Pit Focal Adhesion Cell Cortex Voltage-gated Potassium Channel Complex Membrane Lamellipodium Cell Junction Endocytic Vesicle Dendrite Growth Cone Cortical Cytoskeleton Cell Projection Dendritic Spine Synapse Anchoring Junction Postsynapse Postsynaptic Actin Cytoskeleton Glutamatergic Synapse Mitotic Spindle Midzone	Photoreceptor Outer Segment Photoreceptor Inner Segment Cytoplasm Cytosol Neurofilament Plasma Membrane Postsynaptic Density Membrane Apical Plasma Membrane Growth Cone Brush Border Membrane Cell Projection Neuron Projection Neuronal Cell Body Dendritic Spine Synapse Postsynaptic Membrane Ciliary Membrane
	Molecular Function	Protein Binding Profilin Binding Cadherin Binding Proline-rich Region Binding Arp2/3 Complex Binding	Protein Binding SH3 Domain Binding Synaptic Receptor Adaptor Activity Ionotropic Glutamate Receptor Binding
	Biological Process	Intracellular Protein Transport Endocytosis Receptor-mediated Endocytosis Substrate-dependent Cell Migration, Cell Extension Signal Transduction Actin Cytoskeleton Organization Regulation Of Axon Extension Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Smooth Muscle Contraction Focal Adhesion Assembly Neuron Projection Morphogenesis Cell Motility Positive Regulation Of Chemotaxis Regulation Of Cell Projection Assembly Dendritic Spine Maintenance Extrinsic Apoptotic Signaling Pathway Lamellipodium Organization Modification Of Postsynaptic Actin Cytoskeleton Modification Of Postsynaptic Structure Regulation Of Mitophagy Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Synapse Assembly Learning Positive Regulation Of Cell Population Proliferation Associative Learning Adult Behavior Social Behavior Negative Regulation Of Hippo Signaling Synapse Organization Cognition Long-term Synaptic Potentiation Long-term Synaptic Depression Vocalization Behavior
Pathways		RHO GTPases activate PAKs Clathrin-mediated endocytosis	Neurexins and neuroligins Neurexins and neuroligins
GWAS		No GWAS studies recorded	Bipolar disorder ( 31043756 34002096 ) Eosinophilic esophagitis ( 34506852 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Hip circumference ( 28552196 ) Hodgkin's lymphoma ( 34216518 ) Kawasaki disease ( 33692975 ) Late-onset Alzheimer's disease ( 27770636 ) Obesity-related traits ( 23251661 ) Response to fenofibrate (adiponectin levels) ( 23149075 ) Urate levels in obese individuals ( 25811787 )
Novel Interactors		1 novel interactors: CD5	13 novel interactors: ANO1 BANF1 CLCF1 DNAJC19 DNM1 GMNN MCF2 ORC2 PEX3 PPFIA1 PRSS1 RAB6A RHOT1
Interacting Genes		58 interacting genes: ACD ACTA1 ACTG1 ACTR3 ANKZF1 ARHGAP17 ARHGAP8 ATM CASP3 CD2AP CHD3 CPSF7 CTNND1 CTNND2 CTTNBP2 DNM1 DNM2 EGFR FER FGD1 GRB2 GRIA2 GTSE1 HAX1 HIP1R KCNA2 KEAP1 MET MYLK NHSL2 NXF1 PRPF6 RBM15 RPL23A RPL37 RPL9 RSPH1 SDC3 SF1 SF3B4 SFPQ SH3BP2 SHANK2 SHANK3 SIRT1 SMURF1 SPRR2A SRC SYK TINF2 TJP1 TNK2 TRIM15 USP7 WASL WIPF1 YTHDF1 YTHDF3	21 interacting genes: ACE2 ADGRB2 ADGRL1 ADGRL2 AKT1 ARHGAP12 ARHGEF7 BAIAP2 CTTN DLG4 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DNM2 HOMER1 PPP3CA RIPOR3 SHARPIN SLC9A3 SSTR2
Entrez ID		2017	22941
HPRD ID		01268	04479
Ensembl ID		ENSG00000085733	ENSG00000162105
Uniprot IDs		Q14247 Q53HG7	A0A590UJ45 A6NHU9 Q9UPX8
PDB IDs		1X69 2D1X	8ATJ 8B10
GO Terms Enriched among Interactors		SH3 Domain Binding Cellular Component Assembly Cytoplasm Regulation Of Cellular Component Organization Anchoring Junction Lamellipodium Regulation Of Actin Cytoskeleton Organization Regulation Of Organelle Organization Actin Cytoskeleton Actin Filament Regulation Of Actin Filament-based Process Cytosol Organelle Organization Actin Filament Organization Regulation Of Actin Filament Organization Cellular Response To Chemical Stress Protein Tyrosine Kinase Activity Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Metabolic Process Negative Regulation Of Telomere Maintenance Actin Filament-based Process Regulation Of Cytoskeleton Organization Vesicle Scission Negative Regulation Of Membrane Tubulation Podosome Grb2-EGFR Complex Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of TOR Signaling Cell Projection Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Vesicle-mediated Transport Postsynapse Organization Response To Reactive Oxygen Species Regulation Of Chromosome Organization Positive Regulation Of Cellular Component Organization Cytoskeleton Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Postsynaptic Density Regulation Of Signal Transduction Actin Cytoskeleton Organization Dendritic Spine Morphogenesis Regulation Of Clathrin-dependent Endocytosis Response To Oxidative Stress Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Telomere Maintenance Cellular Response To Reactive Oxygen Species Regulation Of Autophagy Regulation Of Supramolecular Fiber Organization	Synapse Glutamatergic Synapse Postsynaptic Specialization Postsynapse Postsynaptic Density Neuron Projection Modulation Of Chemical Synaptic Transmission Vesicle Scission Latrotoxin Receptor Activity Modification Of Postsynaptic Structure Dendritic Spine Modification Of Synaptic Structure Plasma Membrane Cell Projection Morphogenesis Cell Projection PDZ Domain Binding Regulation Of Synapse Organization Regulation Of Cellular Component Organization Membrane Organization Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Regulation Of Cell Projection Organization Membrane Presynapse Cellular Response To Peptide Neuron Spine Synapse Organization Neuron Projection Morphogenesis Regulation Of Postsynapse Organization Regulation Of Nervous System Development Cell Projection Organization Cholinergic Synapse Cell Junction Organization Protein Localization To Membrane Receptor-mediated Endocytosis Clathrin-coated Pit Negative Regulation Of Cellular Component Organization Cell Cortex Signal Transduction Endocytic Vesicle Membrane Negative Regulation Of CGAS/STING Signaling Pathway Positive Regulation Of Fibroblast Migration Molecular Adaptor Activity Lamellipodium Neuromuscular Junction Proline-rich Region Binding Intracellular Protein Transport Neuron Projection Terminus Calcineurin-NFAT Signaling Cascade G Protein-coupled Receptor Signaling Pathway Schaffer Collateral - CA1 Synapse