MVP and TOLLIP

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MVP	TOLLIP
Description		major vault protein	toll interacting protein
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Nuclear Pore Cytoplasm Cytosol Cytoskeleton Membrane Secretory Granule Lumen Perinuclear Region Of Cytoplasm Extracellular Exosome Ficolin-1-rich Granule Lumen Ribonucleoprotein Complex	Extracellular Region Cytoplasm Endosome Early Endosome Cytosol Nuclear Body Extrinsic Component Of Plasma Membrane Protein-containing Complex Azurophil Granule Lumen Specific Granule Lumen Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Protein Binding Protein Kinase Binding Protein Phosphatase Binding Identical Protein Binding	Interleukin-1, Type I Receptor Binding Protein Binding Kinase Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding SUMO Binding Toll-like Receptor Binding Ubiquitin Binding Molecular Adaptor Activity
	Biological Process	Cell Population Proliferation Protein Transport Negative Regulation Of Protein Autophosphorylation ERBB Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway MRNA Transport Negative Regulation Of Protein Tyrosine Kinase Activity Protein Activation Cascade	Immune System Process Ubiquitin-dependent Protein Catabolic Process Autophagy Inflammatory Response Signal Transduction Phosphorylation Epithelial Cell Differentiation Positive Regulation Of Protein Sumoylation Protein Localization To Endosome Innate Immune Response Leukocyte Activation Interleukin-1-mediated Signaling Pathway
Pathways		Neutrophil degranulation	Neutrophil degranulation Interleukin-1 signaling
Drugs
Diseases
GWAS		Waist circumference adjusted for body mass index ( 34021172)	Gout ( 32238385) Idiopathic pulmonary fibrosis ( 24429156)
Interacting Genes		69 interacting genes: ADAMTSL4 BANP C1orf94 CALCOCO2 CAMK2B CKAP4 DISC1 DLX2 DTX2 EPHX2 ESR1 FMR1 FNDC3B FXR1 FXR2 GIT2 GOLGA2 HP HSPA13 IHO1 KCTD9 KPNA2 KPNA3 MDFI MEOX1 MEOX2 MID2 MRTFA MT-CYB NNT NOTCH2NLA NRF1 NTAQ1 PARP4 PIH1D2 PLSCR1 POT1 PSTPIP1 PTEN PTPN11 RAB3IP RBPMS REL RHOXF2 RIMBP3 RNF10 RNF111 SAXO1 SERTAD1 SKIL SLC2A4 STN1 TCF4 TENT5C TFCP2 TLE5 TOLLIP TP53 TRAF2 TRIM27 TRIM42 TRIP13 TRIP6 TSPOAP1 UBC UBTD2 VAC14 ZBTB32 ZMIZ2	78 interacting genes: ACTMAP ACTN2 ARRDC3 ATXN1 BHLHE40 CDIP1 CHD6 CIMIP2B CPSF6 CSN1S1 CSN2 DAB1 DAZAP2 DCDC2 DDIT4L DZIP3 FAM168A FTH1 GGA1 GGA2 GGA3 GUCD1 HERPUD1 IL1R1 IL1RAP IRAK1 IRAK2 KRTAP13-3 KRTAP15-1 KRTAP19-7 KRTAP6-1 KRTAP6-2 KRTAP7-1 LDB1 MEDAG MSS51 MSX2 MVP N4BP2 NEDD8 NRF1 NTAQ1 ODAM PEG10 PHAF1 PRPF39 PRR20A PRR20B PRR20C PRR20D PRR20E PSMB1 RBFOX1 RBFOX2 RBPMS RHOXF2 RNF167 RNF26 RSPH1 RUNX1 SEPTIN1 SETDB1 SIAH1 STN1 TBX3 TENT5A TLR2 TLR4 TOM1 TOM1L1 TTC9C USP54 WBP2 WRNIP1 XRN2 ZBTB16 ZHX1 ZMYND19
Entrez ID		9961	54472
HPRD ID		05475	05887
Ensembl ID		ENSG00000013364	ENSG00000078902
Uniprot IDs		Q14764 X5D2M8 X5D7K9 X5DNU0	B3KR28 E9PNS3 F2Z2Y8 Q6FIE9 Q8N8J5 Q9H0E2
PDB IDs		1Y7X 9BW5 9BW6 9BW7 9MXH 9MXV	1WGL 2N31
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Biosynthetic Process Cytoplasm Regulation Of Neurogenesis Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity PML Body Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Nervous System Development Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Nucleus Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Translation Regulator Activity Regulation Of Neuronal Synaptic Plasticity TFIIB-class Transcription Factor Binding Viral Penetration Into Host Nucleus Negative Regulation Of Telomere Maintenance Via Telomerase Benzodiazepine Receptor Binding Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II RNA Strand Annealing Activity Regulation Of MiRNA-mediated Gene Silencing Somite Specification Dentate Gyrus Development Single-stranded Telomeric DNA Binding MRNA 3'-UTR Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Post-transcriptional Gene Silencing Regulation Of Macromolecule Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Regulation Of Viral Process Protein Binding Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Chromosome Organization Positive Regulation Of Neurogenesis Intracellular Membraneless Organelle Presynapse Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Catabolic Process	NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Interleukin-1-mediated Signaling Pathway Endosome Membrane Ubiquitin Binding Positive Regulation Of Cellular Response To Macrophage Colony-stimulating Factor Stimulus Golgi To Plasma Membrane Protein Transport Lipopolysaccharide-mediated Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Matrix Metallopeptidase Secretion Protein Binding Toll-like Receptor Signaling Pathway Intermediate Filament Cell Surface Pattern Recognition Receptor Signaling Pathway Establishment Of Protein Localization To Plasma Membrane Phosphatidylinositol Binding Golgi To Plasma Membrane Transport Interleukin-1 Receptor Activity Toll-like Receptor 2 Signaling Pathway Embryonic Hindlimb Morphogenesis Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Protein Localization To Cell Surface LIM Domain Binding Toll Signaling Pathway Lipopolysaccharide Immune Receptor Activity Interleukin-33-mediated Signaling Pathway Hindlimb Morphogenesis Forelimb Morphogenesis Identical Protein Binding
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