GAMT and FOS

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		GAMT	FOS
Gene Name		guanidinoacetate N-methyltransferase	FBJ murine osteosarcoma viral oncogene homolog
Image
Gene Ontology Annotations	Cellular Component	Cytosol Extracellular Vesicular Exosome	Nucleus Nucleoplasm Transcription Factor Complex Endoplasmic Reticulum Cytosol Membrane Neuron Projection
	Molecular Function	Methyltransferase Activity Guanidinoacetate N-methyltransferase Activity	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Transcription Regulatory Region DNA Binding R-SMAD Binding
	Biological Process	Creatine Metabolic Process Creatine Biosynthetic Process Muscle Contraction Spermatogenesis Organ Morphogenesis Methylation Cellular Nitrogen Compound Metabolic Process Regulation Of Multicellular Organism Growth Small Molecule Metabolic Process	Conditioned Taste Aversion Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway DNA Methylation Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Inflammatory Response Transforming Growth Factor Beta Receptor Signaling Pathway Nervous System Development Female Pregnancy Aging Response To Cold Response To Light Stimulus Response To Mechanical Stimulus Response To Gravity Response To Toxic Substance Sleep Cellular Response To Extracellular Stimulus Response To Lipopolysaccharide Response To Progesterone Cellular Response To Hormone Stimulus Response To Cytokine Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Cellular Response To Reactive Oxygen Species TRIF-dependent Toll-like Receptor Signaling Pathway Response To Immobilization Stress Skeletal Muscle Cell Differentiation Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Response To Drug Innate Immune Response Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Stress-activated MAPK Cascade Response To Corticosterone Response To CAMP SMAD Protein Signal Transduction Cellular Response To Calcium Ion
Pathways		Metabolism of amino acids and derivatives Creatine metabolism	Toll Like Receptor 7/8 (TLR7/8) Cascade Cellular Senescence FCERI mediated MAPK activation Toll Like Receptor TLR6:TLR2 Cascade Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade Activation of the AP-1 family of transcription factors MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade Innate Immune System TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade Senescence-Associated Secretory Phenotype (SASP) MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Oxidative Stress Induced Senescence Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Fc epsilon receptor (FCERI) signaling MAPK targets/ Nuclear events mediated by MAP kinases
Drugs		Creatine Guanidine S-Adenosyl-L-Homocysteine N-[Amino(Imino)Methyl]Glycine	Nadroparin
Diseases
GWAS			Inflammatory bowel disease ( 23128233) Periodontal microbiota ( 22699663)
Protein-Protein Interactions		5 interactors: CSNK2B FOS POT1 TERF1 TERF2IP	108 interactors: ANP32E APP AQP1 ARFGAP1 ARL6IP4 ATF2 ATF3 ATF4 ATF7 ATP5I BATF BCL3 CABP1 CARM1 CEBPA CEBPE CEBPG CENPO CFAP57 CLU COPS4 CREB5 CREBBP CSNK2A1 CSNK2A2 CYTH4 DDIT3 EEF1D ELK1 ELK4 EPHB2 ETS1 ETS2 GAMT GATA4 GLB1 GNG11 GRHPR GTF2E2 GTF2F1 GTF2F2 HNF1A HSPA1A JUN JUNB JUND KDM2A LMNA LMO3 LUZP4 MAF MAFB MAFF MAP1B MAP3K7 MAPK1 MAPK7 MITF MTERF4 NACA NCOA1 NCOA2 NCOA3 NCOA6 NCOR2 NEFM NELFB NFATC3 NFKB1 OPTN PML POLR2E PRKAA2 PRKACA PSMC5 RB1 RELA RPS6KA1 RPS6KA2 RPS6KA4 RUNX1 RUNX2 SCHIP1 SET SIRT1 SMAD3 SMARCD1 SPI1 SRA1 STAT1 SUMO1 SUMO2 SUMO3 SUMO4 TAF1 TBP TRO TSC22D3 TSPAN2 UBE2D1 UBE2I UBE2L3 UBR1 USF1 USF2 VDR XBP1 ZNF133
Entrez ID		2593	2353
HPRD ID		03142	01275
Ensembl ID		ENSG00000130005	ENSG00000170345
Uniprot IDs		Q14353	B4DQ65 P01100 Q6FG41
PDB IDs		3ORH	1A02 1FOS 1S9K
Enriched GO Terms of Interacting Partners?		Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance RNA-dependent DNA Replication Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Negative Regulation Of Telomerase Activity Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomerase Activity Regulation Of Chromosome Organization Negative Regulation Of DNA Biosynthetic Process DNA Replication DNA Metabolic Process Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Replication Positive Regulation Of DNA Strand Elongation Negative Regulation Of DNA Recombination At Telomere Regulation Of DNA Replication Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Regulation Of Organelle Organization Telomeric Loop Formation Age-dependent Telomere Shortening Telomere Formation Via Telomerase Chromosome Organization Telomere Maintenance Via Telomere Shortening Protection From Non-homologous End Joining At Telomere Protein Localization To Chromosome, Telomeric Region Conditioned Taste Aversion Positive Regulation Of Helicase Activity Positive Regulation Of Telomerase Activity Telomere Assembly Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Transferase Activity Adiponectin-activated Signaling Pathway Homeostatic Process Aging Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Replicative Cell Aging Regulation Of Nuclear Cell Cycle DNA Replication Endothelial Tube Morphogenesis Positive Regulation Of Telomere Maintenance Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Microtubule Polymerization Regulation Of Double-strand Break Repair Via Homologous Recombination	Transcription, DNA-templated RNA Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Gene Expression Gene Expression RNA Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Nitrogen Compound Metabolic Process Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Cell Differentiation Negative Regulation Of Biosynthetic Process Response To Organic Substance Negative Regulation Of Gene Expression Regulation Of Cellular Process Cellular Response To Organic Substance Developmental Process System Development Viral Process Anatomical Structure Development Cell Differentiation Response To Stress Multicellular Organismal Development Response To External Stimulus Organ Development Negative Regulation Of Transcription From RNA Polymerase II Promoter TRIF-dependent Toll-like Receptor Signaling Pathway
Tagcloud ?		accelerate adipocyte anabolism antagonized assembling concert drive eoc fabp4 fao fas guanidinoacetate hgs hypothesize omentum ovca p63 serous slug smads snail srebps sterol summarizing suppressive tp53 transformative twist upregulates	ap argue capable dimeric dimerization disrupt glucocorticoid heterodimerization homo homodimerization hraralpha hybrid indirect interfere jun liganded occurring promoters protooncoproteins ra raralpha rars repress repression responsive retinoic retinoid rxr rxrs
Tagcloud (Difference) ?		accelerate adipocyte anabolism antagonized assembling concert drive eoc fabp4 fao fas guanidinoacetate hgs hypothesize omentum ovca p63 serous slug smads snail srebps sterol summarizing suppressive tp53 transformative twist upregulates	ap argue capable dimeric dimerization disrupt glucocorticoid heterodimerization homo homodimerization hraralpha hybrid indirect interfere jun liganded occurring promoters protooncoproteins ra raralpha rars repress repression responsive retinoic retinoid rxr rxrs
Tagcloud (Intersection) ?