ALDH1A1

Name	aldehyde dehydrogenase 1 family member A1
Structure
Novel Interactors	1 novel interactors: PTPRF
Interactors	4 interactors: ALDH2 BRCA1 NUPR1 POT1
GO Annotations	Cellular Component	Cytoplasm Cytosol Axon Cell Projection Synapse Extracellular Exosome
	Molecular Function	Nucleotide Binding Retinal Dehydrogenase (NAD+) Activity Aldehyde Dehydrogenase (NAD+) Activity GTPase Activator Activity Androgen Binding Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, NAD Or NADP As Acceptor Benzaldehyde Dehydrogenase (NAD+) Activity Aminobutyraldehyde Dehydrogenase (NAD+) Activity NAD Binding 3-deoxyglucosone Dehydrogenase Activity Acetaldehyde Dehydrogenase (NAD+) Activity
	Biological Process	Retinoid Metabolic Process Aldehyde Metabolic Process Lipid Metabolic Process Gamma-aminobutyric Acid Biosynthetic Process Fructosamine Catabolic Process Maintenance Of Lens Transparency Retinol Metabolic Process Cellular Detoxification Of Aldehyde Negative Regulation Of Cold-induced Thermogenesis
Pathways	RA biosynthesis pathway Fructose catabolism Ethanol oxidation Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Myoepithelial Cells Developmental Lineage of Mammary Stem Cells
Drugs	NADH Vitamin A Tretinoin 1,4-Dithiothreitol
GWAS	Alcohol consumption (drinkers vs non-drinkers) ( 31959922 ) Refractive error ( 32231278 ) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309 ) Sensorimotor dexterity ( 31596458 )
Entrez ID	216
HPRD ID	00001
Ensembl ID	ENSG00000165092
Uniprot IDs	P00352 V9HW83
PDB IDs	4WB9 4WJ9 4WP7 4WPN 4X4L 5AC2 5L2M 5L2N 5L2O 5TEI 6DUM 7JWS 7JWT 7JWU 7JWV 7JWW 7UM9 8D46 8DNO 8ENE 8PVH 8T0N 8T0T 8WFQ
GO Terms Enriched among Interactors ?	Regulation Of Cellular Response To Stress Nitroglycerin Metabolic Process Phenylacetaldehyde Dehydrogenase (NAD+) Activity Regulation Of Serotonin Biosynthetic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Chondroitin Sulfate Proteoglycan Binding Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Histone H2AK127 Ubiquitin Ligase Activity Negative Regulation Of Small Molecule Metabolic Process Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Positive Regulation Of Telomeric Loop Disassembly Negative Regulation Of Cellular Component Organization Aldehyde Dehydrogenase [NAD(P)+] Activity Regulation Of Dopamine Biosynthetic Process Carboxylesterase Activity BRCA1-B Complex Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Receptor Binding 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Telomeric D-loop Binding Telomere Assembly Negative Regulation Of Type B Pancreatic Cell Proliferation Positive Regulation Of Oxidative Phosphorylation Cellular Response To Indole-3-methanol Single-stranded Telomeric DNA Binding Negative Regulation Of Centriole Replication Regulation Of Cellular Component Organization Nuclear Ubiquitin Ligase Complex BRCA1-C Complex Response To Indole-3-methanol Regulation Of DNA Repair Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Telomerase Inhibitor Activity Shelterin Complex Establishment Of Protein Localization To Telomere Regulation Of Female Gonad Development Regulation Of Organelle Assembly BRCA1-A Complex Ubiquitin-modified Histone Reader Activity DEAD/H-box RNA Helicase Binding Positive Regulation Of DNA Metabolic Process Nuclear Telomere Cap Complex Telomeric D-loop Disassembly Ethanol Metabolic Process Aldehyde Catabolic Process Aldehyde Dehydrogenase (NAD+) Activity