CD2AP and BCAR1

Number of citations of the paper that reports this interaction (PMID 10339567)
25

Data Source:
HPRD (in vivo, in vitro)

		CD2AP	BCAR1
Gene Name		CD2-associated protein	breast cancer anti-estrogen resistance 1
Image
Gene Ontology Annotations	Cellular Component	Ruffle Nucleolus Cytoplasm Plasma Membrane Cell-cell Junction Actin Cytoskeleton Filamentous Actin Extracellular Vesicular Exosome	Ruffle Nucleolus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Lamellipodium
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding SH3 Domain Binding	Signal Transducer Activity Protein Binding SH3 Domain Binding Protein Kinase Binding
	Biological Process	Protein Complex Assembly Substrate-dependent Cell Migration, Cell Extension Mitotic Nuclear Division Signal Transduction Negative Regulation Of Transforming Growth Factor Beta1 Production Cell Division Positive Regulation Of Protein Localization To Nucleus Regulation Of Actin Cytoskeleton Reorganization	Regulation Of Cell Growth Actin Filament Organization Cell Adhesion Epidermal Growth Factor Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Blood Coagulation Cell Proliferation Insulin Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Migration Cell Migration Platelet Activation Positive Regulation Of Cell Migration Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Apoptotic Process Platelet-derived Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Hepatocyte Growth Factor Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Cell Division Cell Chemotaxis
Pathways		Nephrin interactions	Signaling by PDGF Signaling by VEGF Downstream signal transduction p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling Platelet activation, signaling and aggregation Platelet Aggregation (Plug Formation) VEGFA-VEGFR2 Pathway
Drugs
Diseases
GWAS		Alzheimer's disease (late onset) ( 21460841)	Crohn's disease (time to surgery) ( 23665963)
Protein-Protein Interactions		30 interactors: BCAR1 CAPZA1 CBL CD2 CTTN FYN GRB2 GZMB HBP1 HCK HOXC11 KHDRBS1 MVB12A NPHS1 NPHS2 NR2C2 NR4A1 PDCD6IP PIK3R1 PKD2 PSTPIP1 PTGES3 RAB4A SH3GL2 SOS1 SOS2 SRC UBC WTIP YES1	52 interactors: ABL1 AJUBA ARHGAP32 BMX CASP3 CD2AP CRK CRKL CSPG4 DOCK1 E2F2 EFS ESR1 FES FXYD6 FYB FYN GRB2 GSN HCK HSPA5 INPPL1 LCK LYN MMP14 NCK1 NEDD9 NPHP1 PIK3R1 PKD1 PPAP2B PPP1R15A PTK2 PTK2B PTPN1 PTPN12 PTPRA PTPRF PTPRH PXN RAN RAPGEF1 SH2D3A SH2D3C SH3KBP1 SRC SRCIN1 TRIP6 TUBA4A UHRF2 VPS11 YWHAZ
Entrez ID		23607	9564
HPRD ID		05026	04248
Ensembl ID		ENSG00000198087	ENSG00000050820
Uniprot IDs		Q9Y5K6	B2RBL9 B3KWE2 F5H855 P56945
PDB IDs		2FEI 2J6F 2J6K 2J6O 2J7I 3AA6 3LK4 3U23	1WYX 3T6G
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Growth Factor Stimulus Neurotrophin TRK Receptor Signaling Pathway Response To Growth Factor Neurotrophin Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Immune Response-regulating Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune System Process Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Signaling Regulation Of Cellular Component Organization Cell Communication Signal Transduction Leukocyte Migration Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Regulation Of ERBB Signaling Pathway Locomotion Cellular Response To Hormone Stimulus Cellular Response To Organic Substance Blood Coagulation Hemostasis Innate Immune Response Cell Surface Receptor Signaling Pathway Cell Migration Cellular Response To Peptide Hormone Stimulus Regulation Of Immune Response Cellular Response To Peptide Cell Motility Response To Organic Substance Immune Response Regulation Of Immune System Process Regulation Of Body Fluid Levels Positive Regulation Of Organelle Organization Regulation Of Cellular Process Cellular Response To Stimulus Wound Healing Chemotaxis T Cell Costimulation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Response To Stimulus	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Peptidyl-tyrosine Autophosphorylation Signaling Cell Communication Cellular Response To Stimulus Response To Stimulus Cell Migration Cell Motility Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Platelet Activation Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Immune Response-activating Cell Surface Receptor Signaling Pathway Locomotion Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Response To Wounding ERBB Signaling Pathway Positive Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Wound Healing Regulation Of Protein Kinase Activity Regulation Of Signal Transduction Cell Adhesion Regulation Of Cellular Component Organization Blood Coagulation Regulation Of Catalytic Activity Hemostasis Protein Autophosphorylation Positive Regulation Of Protein Metabolic Process Fc Receptor Signaling Pathway Innate Immune Response Response To Organonitrogen Compound Cellular Response To Organonitrogen Compound Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Phosphorylation Cellular Response To Peptide Hormone Stimulus Signal Complex Assembly Regulation Of Signaling
Tagcloud ?		abca7 bin1 cass4 cd33 celf1 chapter discoveries drb1 drb5 epha1 fermt2 inpp5d mef2c ms4a4 ms4a6 nme8 picalm pld3 psen1 psen2 ptk2b rin3 slc24a4 sorl1 touch trem2 trip4 unsuspected zcwpw1	aldh1a1 anxa1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Difference) ?		abca7 bin1 cass4 cd33 celf1 chapter discoveries drb1 drb5 epha1 fermt2 inpp5d mef2c ms4a4 ms4a6 nme8 picalm pld3 psen1 psen2 ptk2b rin3 slc24a4 sorl1 touch trem2 trip4 unsuspected zcwpw1	aldh1a1 anxa1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Intersection) ?