CD2AP and BCAR1

Number of citations of the paper that reports this interaction (PubMedID 10339567)
41

Data Source:
HPRD (in vivo, in vitro)

		CD2AP	BCAR1
Description		CD2 associated protein	BCAR1 scaffold protein, Cas family member
Image
GO Annotations	Cellular Component	Fibrillar Center Ruffle Podosome Nuclear Envelope Lumen Cytoplasm Late Endosome Cytoskeleton Actin Filament Plasma Membrane Cell-cell Junction Actin Cytoskeleton Axon Dendrite Growth Cone Cell Leading Edge Neuromuscular Junction Filamentous Actin Vesicle Trans-Golgi Network Membrane Protein-containing Complex Centriolar Satellite Slit Diaphragm Cell Projection Neuron Projection Extracellular Exosome Anchoring Junction Cell Periphery	Ruffle Cytoplasm Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane Lamellipodium Axon Cell Projection Anchoring Junction
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding SH3 Domain Binding Clathrin Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding Identical Protein Binding Cadherin Binding Actin Filament Binding	Protein Binding SH3 Domain Binding Protein Kinase Binding
	Biological Process	Immunological Synapse Formation Kidney Development Liver Development Endothelium Development Lipid Metabolic Process Apoptotic Process Substrate-dependent Cell Migration, Cell Extension Inflammatory Response Response To Oxidative Stress Actin Filament Organization Signal Transduction Cell Population Proliferation Male Gonad Development Protein Secretion Response To Wounding Response To Virus Gene Expression Protein Transport Cell Migration Actin Filament Polymerization Cell Differentiation Protein Catabolic Process Neuron Projection Development Rab Protein Signal Transduction Glomerulus Development Response To Insulin Transforming Growth Factor Beta1 Production Negative Regulation Of Transforming Growth Factor Beta1 Production Regulation Of Actin Cytoskeleton Organization Maintenance Of Blood-brain Barrier Neurotrophin Signaling Pathway Nerve Growth Factor Signaling Pathway Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Neuron Apoptotic Process Cell-cell Adhesion Mediated By Cadherin Cell-cell Junction Organization D-glucose Import Filopodium Assembly Neurotrophin TRK Receptor Signaling Pathway Regulation Of Synaptic Plasticity Lymph Node Development Collateral Sprouting Positive Regulation Of Protein Secretion Synapse Organization T Cell Receptor Signaling Pathway Negative Regulation Of Small GTPase Mediated Signal Transduction Protein Heterooligomerization Cell Division Stress-activated MAPK Cascade Localization Of Cell Adipose Tissue Development Membrane Organization Protein-containing Complex Assembly ERK1 And ERK2 Cascade Response To Transforming Growth Factor Beta Podocyte Differentiation Renal Albumin Absorption Positive Regulation Of Protein Localization To Nucleus Response To Glial Cell Derived Neurotrophic Factor	Regulation Of Cell Growth Actin Filament Organization Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Insulin Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Migration Cell Migration Positive Regulation Of Cell Migration Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Apoptotic Process Platelet-derived Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Hepatocyte Growth Factor Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Cell Division Cell Chemotaxis Endothelin Receptor Signaling Pathway
Pathways		Nephrin family interactions	Downstream signal transduction p130Cas linkage to MAPK signaling for integrins VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
Drugs
Diseases		Nephrotic syndrome and focal segmental glomerulosclerosis
GWAS		Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 21460841 24162737 30617256) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Family history of Alzheimer's disease ( 30617256) Femur bone mineral density x serum urate levels interaction ( 34046847) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Hip circumference adjusted for BMI ( 34021172) Immature fraction of reticulocytes ( 27863252 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Plasma homocysteine levels ( 26519441) Red cell distribution width ( 32888494 27863252) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)	Advanced age-related macular degeneration ( 26691988) Alcoholic chronic pancreatitis ( 28754779) Chronic obstructive pulmonary disease or coronary artery disease (pleiotropy) ( 30940143) Coronary artery disease ( 33020668) Crohn's disease (time to surgery) ( 23665963) Intracranial aneurysm ( 33199917) Myocardial infarction ( 33532862) Offspring birth weight ( 31043758) Pancreatic cancer ( 25086665 29422604) Type 1 diabetes ( 25751624) Type 2 diabetes ( 22885922 29358691 30297969)
Interacting Genes		34 interacting genes: ARAP3 BCAR1 CAPZA1 CBL CBLB CD2 CTTN FYN GRB2 GZMB HBP1 HCK HOXC11 KHDRBS1 MVB12A NPHS1 NPHS2 NR2C2 NR4A1 PDCD6IP PIK3R1 PKD2 PSTPIP1 PTGES3 RAB4A RIN3 SH3GL2 SOS1 SOS2 SRC UBC UBE2I WTIP YES1	65 interacting genes: ABL1 AJUBA ANKS1A ARHGAP32 BMX CASP3 CD2AP COPB1 CRK CRKL CSPG4 DOCK1 DOK7 E2F2 EEIG1 EFS ESR1 FAM90A1 FES FXYD6 FYB1 FYN GLIS2 GRB2 GSN HCK HSPA5 INPPL1 LCK LYN MMP14 NCK1 NCK2 NEDD9 NPHP1 PIK3R1 PKD1 PLPP3 PPP1R15A PRAM1 PTEN PTK2 PTK2B PTPN1 PTPN12 PTPRA PTPRF PTPRH PXN RAN RAPGEF1 SH2D3A SH2D3C SH3KBP1 SRC SRCIN1 TNS3 TRIP6 TUBA4A UHRF2 USP2 VCL VPS11 YES1 YWHAZ
Entrez ID		23607	9564
HPRD ID		05026	04248
Ensembl ID		ENSG00000198087	ENSG00000050820
Uniprot IDs		Q9Y5K6	B3KWE2 P56945
PDB IDs		2FEI 2J6F 2J6K 2J6O 2J7I 3AA6 3LK4 3U23 4WCI 4X1V 7DS6 7DS8	1WYX 3T6G 5O2M 5O2P 5O2Q
Enriched GO Terms of Interacting Partners?		Phosphotyrosine Residue Binding Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune System Process Immune Response-activating Signaling Pathway Cell Surface Receptor Signaling Pathway Cytosol SH3 Domain Binding Cellular Response To Platelet-derived Growth Factor Stimulus Immune Effector Process Immune Response-regulating Signaling Pathway Activation Of Immune Response Fc Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Response To Platelet-derived Growth Factor Cell-cell Junction Fc Receptor Mediated Stimulatory Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Ephrin Receptor Binding Positive Regulation Of Immune System Process Regulation Of ERBB Signaling Pathway Negative Regulation Of Inflammatory Response To Antigenic Stimulus Positive Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Insulin Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Regulation Of T Cell Activation Regulation Of Immune System Process Actin Filament Regulation Of Cellular Component Organization Cellular Response To Growth Factor Stimulus Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response Focal Adhesion Non-membrane Spanning Protein Tyrosine Kinase Activity Natural Killer Cell Mediated Immunity T Cell Costimulation Regulation Of Endocytosis Positive Regulation Of Actin Filament Polymerization Response To Growth Factor Membrane Raft Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Regulation Of Transport Cytoplasm Actin Cytoskeleton Organization Leukocyte Migration	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Focal Adhesion Non-membrane Spanning Protein Tyrosine Kinase Activity Phosphotyrosine Residue Binding Regulation Of Cell Adhesion Cell Migration Ephrin Receptor Binding Cell Surface Receptor Signaling Pathway Signal Transduction Cell Motility Regulation Of Cell-substrate Adhesion Ephrin Receptor Signaling Pathway Anchoring Junction Immune Response-activating Cell Surface Receptor Signaling Pathway Signal Complex Assembly Regulation Of Immune System Process Integrin-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Immune System Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Protein Tyrosine Kinase Activity Fc Receptor Mediated Stimulatory Signaling Pathway Plasma Membrane Immune Response-activating Signaling Pathway Regulation Of Cell Motility Antigen Receptor-mediated Signaling Pathway SH3 Domain Binding Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response Regulation Of Locomotion Regulation Of Intracellular Signal Transduction Immune Response-regulating Signaling Pathway Regulation Of Cell Migration Fc Receptor Signaling Pathway Activation Of Immune Response Regulation Of Cell-matrix Adhesion Intracellular Signal Transduction Cytosol Regulation Of Cytoskeleton Organization Cytoplasm Regulation Of Signal Transduction Cell Adhesion Cell-cell Junction Regulation Of Cell Junction Assembly Plasma Membrane Bounded Cell Projection Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cell Adhesion
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