CD2AP and CD2

Number of citations of the paper that reports this interaction (PMID 9741631)
143

Data Source:
HPRD (two hybrid, in vivo)

		CD2AP	CD2
Gene Name		CD2-associated protein	CD2 molecule
Image
Gene Ontology Annotations	Cellular Component	Ruffle Nucleolus Cytoplasm Plasma Membrane Cell-cell Junction Actin Cytoskeleton Filamentous Actin Extracellular Vesicular Exosome	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane Cytoplasmic Side Of Plasma Membrane Cell Surface Anchored Component Of Plasma Membrane
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding SH3 Domain Binding	Receptor Activity Receptor Binding Protein Binding Protein Homodimerization Activity
	Biological Process	Protein Complex Assembly Substrate-dependent Cell Migration, Cell Extension Mitotic Nuclear Division Signal Transduction Negative Regulation Of Transforming Growth Factor Beta1 Production Cell Division Positive Regulation Of Protein Localization To Nucleus Regulation Of Actin Cytoskeleton Reorganization	Membrane Raft Polarization Apoptotic Process Cell Surface Receptor Signaling Pathway Blood Coagulation Single Organismal Cell-cell Adhesion Natural Killer Cell Activation Positive Regulation Of Myeloid Dendritic Cell Activation Positive Regulation Of Tumor Necrosis Factor Production Heterotypic Cell-cell Adhesion T Cell Activation Regulation Of T Cell Differentiation Leukocyte Migration Positive Regulation Of Interferon-gamma Secretion Positive Regulation Of Interleukin-8 Secretion
Pathways		Nephrin interactions	Cell surface interactions at the vascular wall
Drugs			Alefacept Alpha-D-Mannose
Diseases
GWAS		Alzheimer's disease (late onset) ( 21460841)
Protein-Protein Interactions		30 interactors: BCAR1 CAPZA1 CBL CD2 CTTN FYN GRB2 GZMB HBP1 HCK HOXC11 KHDRBS1 MVB12A NPHS1 NPHS2 NR2C2 NR4A1 PDCD6IP PIK3R1 PKD2 PSTPIP1 PTGES3 RAB4A SH3GL2 SOS1 SOS2 SRC UBC WTIP YES1	19 interactors: CD247 CD2AP CD2BP2 CD4 CD48 CD5 CD53 CD58 CD59 FYN LCK LGALS1 LINC00311 LYAR MXD1 PSTPIP1 PTPRC SH3KBP1 SP1
Entrez ID		23607	914
HPRD ID		05026	01750
Ensembl ID		ENSG00000198087	ENSG00000116824
Uniprot IDs		Q9Y5K6	P06729 Q53F96
PDB IDs		2FEI 2J6F 2J6K 2J6O 2J7I 3AA6 3LK4 3U23	1CDB 1GYA 1HNF 1L2Z 1QA9 2J6O 2J7I
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Growth Factor Stimulus Neurotrophin TRK Receptor Signaling Pathway Response To Growth Factor Neurotrophin Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Immune Response-regulating Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune System Process Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Signaling Regulation Of Cellular Component Organization Cell Communication Signal Transduction Leukocyte Migration Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Regulation Of ERBB Signaling Pathway Locomotion Cellular Response To Hormone Stimulus Cellular Response To Organic Substance Blood Coagulation Hemostasis Innate Immune Response Cell Surface Receptor Signaling Pathway Cell Migration Cellular Response To Peptide Hormone Stimulus Regulation Of Immune Response Cellular Response To Peptide Cell Motility Response To Organic Substance Immune Response Regulation Of Immune System Process Regulation Of Body Fluid Levels Positive Regulation Of Organelle Organization Regulation Of Cellular Process Cellular Response To Stimulus Wound Healing Chemotaxis T Cell Costimulation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Response To Stimulus	Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of T Cell Activation T Cell Costimulation Positive Regulation Of Cell Activation Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Regulation Of Cell Activation Immune System Process Regulation Of Defense Response To Virus By Virus Regulation Of Cell Adhesion T Cell Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune System Process Defense Response Regulation Of Defense Response To Virus Innate Immune Response Cell Migration Locomotion Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response Cell Motility Signal Transduction Cellular Response To Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Activation Response To Wounding Signaling Lymphocyte Activation Response To Stimulus Cell Communication Blood Coagulation Hemostasis Immune Response-regulating Signaling Pathway Positive Regulation Of Gamma-delta T Cell Differentiation Leukocyte Activation Leukocyte Migration Regulation Of Immune Response Lymphocyte Differentiation Positive Regulation Of Gamma-delta T Cell Activation Single Organismal Cell-cell Adhesion Response To Stress Viral Process T Cell Aggregation T Cell Activation Regulation Of Gamma-delta T Cell Differentiation Lymphocyte Aggregation
Tagcloud ?		abca7 bin1 cass4 cd33 celf1 chapter discoveries drb1 drb5 epha1 fermt2 inpp5d mef2c ms4a4 ms4a6 nme8 picalm pld3 psen1 psen2 ptk2b rin3 slc24a4 sorl1 touch trem2 trip4 unsuspected zcwpw1	2c4 assign b10 b3 b9 complementation crossed crosses crossing facs gbp guanylate hlas hybrids ifn jak1 oas oligoadenylate pairwise permitted responsiveness restore rounds submitted synthetase u3 u4 unresponsive unresponsiveness
Tagcloud (Difference) ?		abca7 bin1 cass4 cd33 celf1 chapter discoveries drb1 drb5 epha1 fermt2 inpp5d mef2c ms4a4 ms4a6 nme8 picalm pld3 psen1 psen2 ptk2b rin3 slc24a4 sorl1 touch trem2 trip4 unsuspected zcwpw1	2c4 assign b10 b3 b9 complementation crossed crosses crossing facs gbp guanylate hlas hybrids ifn jak1 oas oligoadenylate pairwise permitted responsiveness restore rounds submitted synthetase u3 u4 unresponsive unresponsiveness
Tagcloud (Intersection) ?