CD2AP and MVB12A

Number of citations of the paper that reports this interaction (PubMedID 16895919)
0

Data Source:
HPRD (in vivo)

		CD2AP	MVB12A
Description		CD2 associated protein	multivesicular body subunit 12A
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GO Annotations	Cellular Component	Fibrillar Center Ruffle Podosome Nuclear Envelope Lumen Cytoplasm Late Endosome Cytoskeleton Actin Filament Plasma Membrane Cell-cell Junction Actin Cytoskeleton Axon Dendrite Growth Cone Cell Leading Edge Neuromuscular Junction Filamentous Actin Vesicle Trans-Golgi Network Membrane Protein-containing Complex Centriolar Satellite Slit Diaphragm Cell Projection Neuron Projection Extracellular Exosome Anchoring Junction Cell Periphery	ESCRT I Complex Nucleus Cytoplasm Endosome Centrosome Cytosol Cytoskeleton Endosome Membrane Membrane Late Endosome Membrane Vesicle Extracellular Exosome
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding SH3 Domain Binding Clathrin Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding Identical Protein Binding Cadherin Binding Actin Filament Binding	Protein Binding Lipid Binding SH3 Domain Binding Ubiquitin Binding
	Biological Process	Immunological Synapse Formation Kidney Development Liver Development Endothelium Development Lipid Metabolic Process Apoptotic Process Substrate-dependent Cell Migration, Cell Extension Inflammatory Response Response To Oxidative Stress Actin Filament Organization Signal Transduction Cell Population Proliferation Male Gonad Development Protein Secretion Response To Wounding Response To Virus Gene Expression Protein Transport Cell Migration Actin Filament Polymerization Cell Differentiation Protein Catabolic Process Neuron Projection Development Rab Protein Signal Transduction Glomerulus Development Response To Insulin Transforming Growth Factor Beta1 Production Negative Regulation Of Transforming Growth Factor Beta1 Production Regulation Of Actin Cytoskeleton Organization Maintenance Of Blood-brain Barrier Neurotrophin Signaling Pathway Nerve Growth Factor Signaling Pathway Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Neuron Apoptotic Process Cell-cell Adhesion Mediated By Cadherin Cell-cell Junction Organization D-glucose Import Filopodium Assembly Neurotrophin TRK Receptor Signaling Pathway Regulation Of Synaptic Plasticity Lymph Node Development Collateral Sprouting Positive Regulation Of Protein Secretion Synapse Organization T Cell Receptor Signaling Pathway Negative Regulation Of Small GTPase Mediated Signal Transduction Protein Heterooligomerization Cell Division Stress-activated MAPK Cascade Localization Of Cell Adipose Tissue Development Membrane Organization Protein-containing Complex Assembly ERK1 And ERK2 Cascade Response To Transforming Growth Factor Beta Podocyte Differentiation Renal Albumin Absorption Positive Regulation Of Protein Localization To Nucleus Response To Glial Cell Derived Neurotrophic Factor	Protein Transport Macroautophagy Virus Maturation Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Receptor Catabolic Process Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Viral Budding Membrane Fission
Pathways		Nephrin family interactions	Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy
Drugs
Diseases		Nephrotic syndrome and focal segmental glomerulosclerosis
GWAS		Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 21460841 24162737 30617256) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Family history of Alzheimer's disease ( 30617256) Femur bone mineral density x serum urate levels interaction ( 34046847) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Hip circumference adjusted for BMI ( 34021172) Immature fraction of reticulocytes ( 27863252 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Plasma homocysteine levels ( 26519441) Red cell distribution width ( 32888494 27863252) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		34 interacting genes: ARAP3 BCAR1 CAPZA1 CBL CBLB CD2 CTTN FYN GRB2 GZMB HBP1 HCK HOXC11 KHDRBS1 MVB12A NPHS1 NPHS2 NR2C2 NR4A1 PDCD6IP PIK3R1 PKD2 PSTPIP1 PTGES3 RAB4A RIN3 SH3GL2 SOS1 SOS2 SRC UBC UBE2I WTIP YES1	8 interacting genes: APP CD2AP HSF2BP OXTR PPP1R27 SH3KBP1 SNCA UBC
Entrez ID		23607	93343
HPRD ID		05026	14298
Ensembl ID		ENSG00000198087	ENSG00000141971
Uniprot IDs		Q9Y5K6	Q96EY5
PDB IDs		2FEI 2J6F 2J6K 2J6O 2J7I 3AA6 3LK4 3U23 4WCI 4X1V 7DS6 7DS8	6VME
Enriched GO Terms of Interacting Partners?		Phosphotyrosine Residue Binding Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune System Process Immune Response-activating Signaling Pathway Cell Surface Receptor Signaling Pathway Cytosol SH3 Domain Binding Cellular Response To Platelet-derived Growth Factor Stimulus Immune Effector Process Immune Response-regulating Signaling Pathway Activation Of Immune Response Fc Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Response To Platelet-derived Growth Factor Cell-cell Junction Fc Receptor Mediated Stimulatory Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Ephrin Receptor Binding Positive Regulation Of Immune System Process Regulation Of ERBB Signaling Pathway Negative Regulation Of Inflammatory Response To Antigenic Stimulus Positive Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Insulin Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Regulation Of T Cell Activation Regulation Of Immune System Process Actin Filament Regulation Of Cellular Component Organization Cellular Response To Growth Factor Stimulus Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response Focal Adhesion Non-membrane Spanning Protein Tyrosine Kinase Activity Natural Killer Cell Mediated Immunity T Cell Costimulation Regulation Of Endocytosis Positive Regulation Of Actin Filament Polymerization Response To Growth Factor Membrane Raft Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Regulation Of Transport Cytoplasm Actin Cytoskeleton Organization Leukocyte Migration	Collateral Sprouting Regulation Of Presynapse Organization Regulation Of Long-term Neuronal Synaptic Plasticity Growth Cone Regulation Of Presynapse Assembly Regulation Of Neurotransmitter Uptake Nuclear Envelope Lumen Cellular Response To Copper Ion Supramolecular Fiber Organization Regulation Of Synaptic Plasticity Amyloid Fibril Formation Microglial Cell Activation Response To Copper Ion Leukocyte Activation Involved In Inflammatory Response Regulation Of Neuron Apoptotic Process Protein Complex Oligomerization Synapse Organization Amyloid-beta Complex Regulation Of Neuronal Synaptic Plasticity Apoptotic Process Growth Cone Lamellipodium Neuron Projection Regulation Of Response To Calcium Ion Macrophage Activation Response To Growth Factor Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process Oxytocin Receptor Activity Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Programmed Cell Death Cell Death Adult Locomotory Behavior Response To Interleukin-1 Axon Acetylcholine Receptor Activator Activity Protein Tetramerization Endocytosis Lipoprotein Particle Positive Regulation Of Protein Import Positive Regulation Of Protein Localization Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Cell Junction Organization PTB Domain Binding
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